合成生物与生物制造 · 全部实体（第 3 / 99 页）

本页收录第 201–300 条，共 9808 条 · 返回 合成生物与生物制造 首页

• Mechanized Qu-making may contribute to lactic acid bacteria overproliferation in Hongqu rice wine brewing: Insights into microbial dysbiosis and flavor quality deterioration.
  europepmc 2026 置信度 0.76
• Formaldehyde metabolism in the biocatalytic upgrading of lignin.
  Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to commodity chemicals sho…
  europepmc 2026 置信度 0.87
• Metabolic engineering of <i>Escherichia coli</i> for the biosynthesis of nylon 6 and nylon 6,6 monomers.
  europepmc 2026 置信度 0.76
• Sulfamethoxazole and acetaminophen increase methane yield while exerting different effects on key metabolic pathways and antibiotic resistance gene dynamics during anaerobic digestion.
  europepmc 2026 置信度 0.76
• Molecular Access Engineering for Microbial Biocatalysis: from Enzyme Tunnels to Microbial Cell Factories.
  europepmc 2026 置信度 0.76
• Targeted NIR-II Photothermal Therapy Enabled by Bioorthogonal Click Reaction With Olympicenyl Radical Nanoparticles.
  europepmc 2026 置信度 0.72
• Therapeutic targeting of brain bioenergetics in Alzheimer's disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction.
  europepmc 2026 置信度 0.72
• Bio-Orthogonally Click-Assembled Macrophage Spheroids on Micropatterned Scaffolds for Sustained M1 Polarization and Antitumor Function.
  europepmc 2026 置信度 0.72
• Photosynthetic production of glutamine through metabolic analysis-based engineering of <i>Picosynechococcus</i> sp. PCC 7002.
  europepmc 2026 置信度 0.76
• Ethnomedicinal Uses, Phytochemistry and Bioactivities of Halophytes and Salt-Tolerant Plants with Potential Against Metabolic Syndrome: A Comprehensive Review.
  europepmc 2026 置信度 0.76
• A revised ribosome-antibiotic model with proportional feedback synthesis explains recovery from translation inhibition.
  europepmc 2026 置信度 0.76
• CYP2C19-mediated metabolic activation and OAT3/P-gp-associated transport contribute to Dioscorea bulbifera L.-induced hepatotoxicity.
  europepmc 2026 置信度 0.72
• Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299].
  europepmc 2026 置信度 0.68
• From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.
  europepmc 2026 置信度 0.72
• Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.
  europepmc 2026 置信度 0.76
• Spatially resolved proteomics provides insights into the normal-dysplasia-tumor continuum in oral squamous cell carcinoma.
  europepmc 2026 置信度 0.72
• E3 Ubiquitin ligases molecular strategies against proteostasis defects of imperfect ageing.
  Ageing is a process of continuous decline of cellular health. This decline could be attributed to loss of functions to various crucial protein players regulating the triage of cellular physiology. Systematic decline of cellular proteostasis is one major change…
  europepmc 2026 置信度 0.87
• Cryo-EM structure of Escherichia coli HPII catalase serendipitously co-purified with a recombinant adhesin construct.
  europepmc 2026 置信度 0.68
• Smoking reshapes systemic metabolic coordination across lung cancer subtypes: a multicenter total-body <sup>18</sup>F-FDG PET/CT study with tumor habitat imaging.
  europepmc 2026 置信度 0.72
• Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.
  Medium-chain carboxylic acids, such as n-caproate, are attractive sustainable platform chemicals. However, their microbial production is often limited by electron availability and low product selectivity. This study investigated the effect of hydrogen suppleme…
  europepmc 2026 置信度 0.94 biotechnologybiochemistrygeneticsbiological sciences not elsewhere classifiedchemistry
• Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.
  europepmc 2026 置信度 0.68
• Editorial: Biodegradation of agricultural pesticides.
  europepmc 2026 置信度 0.72
• Maximizing Nanoscale Disorder in Block Copolymers for Orientation-Independent SERS Platform Toward Non-Invasive Diagnostics.
  europepmc 2026 置信度 0.72
• Single-electrode simultaneous detection of tonic dopamine and serotonin <i>in vivo</i> using an interleaved cyclic square wave voltammetry approach.
  europepmc 2026 置信度 0.68
• Global transcriptional rewiring and dual-compartment engineering for efficient 3-hydroxypropionic acid production in Saccharomyces cerevisiae.
  europepmc 2026 置信度 0.72
• Microbial Inulinases: Characterization, Properties, and Potential Contribution to Metabolic and Nutritional Health.
  europepmc 2026 置信度 0.76
• Fecal Microbiome and Serum Metabolome Profiles of the Ovarian Failure Mouse Model.
  europepmc 2026 置信度 0.72
• Temporal interpretation of physiologic group contributions for ICU mortality prediction.
  europepmc 2026 置信度 0.68
• BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer.
  europepmc 2026 置信度 0.68
• Corrigendum to "Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway" [Phytomedicine, 125 (2024), 155299].
  europepmc 2026 置信度 0.68
• Exogenous quorum sensing signal enhances central energy metabolism to fuel biofilm formation and denitrification on microplastics.
  europepmc 2026 置信度 0.72
• Safe and resource-aware microbial design for food production.
  Precision fermentation is redefining microbial food manufacturing by enabling programmable biosynthesis of nutrients and functional ingredients. Despite this progress, industrial-scale deployment is limited by metabolic burden, growth-production trade-offs, bi…
  europepmc 2026 置信度 0.87
• Optimizing rhamnolipid biosynthesis: evaluating predictive methods using <i>Pseudomonas aeruginosa</i> mutants.
  europepmc 2026 置信度 0.76
• ATTNSOM: learning cross-isoform attention for cytochrome P450 site-of-metabolism prediction.
  europepmc 2026 置信度 0.68
• Mesenchymal Stem Cell-Derived Exosomes Improve Aging-Related Changes in Liver Lipid Metabolism by Enhancing Autophagy.
  europepmc 2026 置信度 0.72
• Different brain spatial metabolic patterns characterizing different subtypes of multiple system atrophy.
  europepmc 2026 置信度 0.72
• Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.
  europepmc 2026 置信度 0.68
• Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy.
  europepmc 2026 置信度 0.72
• Evaluation of ornithogalum sigmoideum extract-induced cytotoxicity and expression of xenobiotic metabolism-related genes in HT29 cells.
  europepmc 2026 置信度 0.76
• Beyond GLP-1 Agonists: Plant-Derived Bioactive Compounds as Adjunctive Strategies for Obesity Management.
  europepmc 2026 置信度 0.72
• Croaker Fish Bone-Derived Hydroxyapatite as a Sustainable Source for 3D-Printed Scaffolds for Bone Regeneration.
  europepmc 2026 置信度 0.68
• Dendrobium nobile Lindl. alleviates acute alcoholic liver injury in mice by modulating bile acid metabolism via the enterohepatic circulation.
  europepmc 2026 置信度 0.68
• Ethnopharmacological landscape of Azadirachta indica (Neem): Phytochemical diversity bridging traditional heritage and modern medicine.
  europepmc 2026 置信度 0.68
• Improving protein secretion in yeasts: From secretion leader engineering and AI-driven prediction to bioprocess performance.
  Yeast is widely used for recombinant protein production because it supports eukaryotic protein expression and high-cell-density cultivation. Efficient secretion depends on secretion leaders, short N-terminal sequences that direct nascent polypeptides into the …
  europepmc 2026 置信度 0.94 biologycomputational biologymaterials sciencesynthetic biologycomputer science
• Strain-promoted click chemistry boosts microbubbles for targeted ultrasound imaging and cancer chemotherapy.
  europepmc 2026 置信度 0.72
• From pathophysiology to therapy: molecular mechanisms of stem cell and extracellular vesicle-mediated repair in diabetic peripheral neuropathy.
  europepmc 2026 置信度 0.72
• Modular pathway engineering enables gram-scale de novo biosynthesis of narirutin in yeast.
  europepmc 2026 置信度 0.76
• Carbon-Mediated Rechargeable Operation for Light-Driven Ammonia Production Using Quantum Dot-Azotobacter vinelandii Hybrids.
  europepmc 2026 置信度 0.68
• Differential Regulation of Pre-Harvest Sprouting by <i>OsERF1</i> and <i>OsERF94</i> Through Hormone Signaling and Metabolic Reprogramming in Rice.
  europepmc 2026 置信度 0.72
• TMEM135 deficiency prevents intestinal lipid accumulation by coordinating lipid uptake and oxidation through ELOVL6-mediated PPARα activation.
  europepmc 2026 置信度 0.68
• Matrix-Aware Electrochemical Sensing: A Neural Network Approach to Deciphering Medium-Specific Surface Dynamics.
  Accurate monitoring in complex biofluids remains challenging due to unpredictable skin - electrode interfacial interference and matrix-dependent impedance variations. Here, we present an intelligent enzymatic microneedle platform that achieves calibration-effi…
  europepmc 2026 置信度 0.94 computer sciencecomputer and information sciencesartificial intelligencecs.lgcs.ai
• Aging time-dependent non-volatile chemical and microbial dynamics in Pericarpium Citri Reticulatae 'Chachiensis' from multi-regional origins.
  europepmc 2026 置信度 0.72
• Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study.
  europepmc 2026 置信度 0.72
• Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.
  europepmc 2026 置信度 0.68
• Corrigendum to "Exploring community succession and metabolic changes in corn gluten meal-bran mixed wastes during fermentation" [J. Environ. Manag. 366 (2024) 121684].
  europepmc 2026 置信度 0.76
• Air-liquid interface-centered oxygen engineering in human brain organoids: intact, sliced, and microfluidic extensions.
  europepmc 2026 置信度 0.72
• The role of coumarin biosynthesis in modulating plant drought responses: insights from PpBMT overexpression in Arabidopsis.
  europepmc 2026 置信度 0.76
• Temporal decoupling between cyanobacterial inactivation and microcystin release under radiation-induced oxidative stress: implications of toxin dynamics in aquatic environments.
  europepmc 2026 置信度 0.68
• Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.
  europepmc 2026 置信度 0.72
• Overlapping Diabetes- and CKD-Driven Vascular Phenotypes of Peripheral Artery Disease: A Limb-First Framework for Chronic Limb-Threatening Ischemia.
  europepmc 2026 置信度 0.68
• Gut microbiota mediates dietary adaptation across spatially varying diets in the endangered Przewalski's gazelle (Procapra przewalskii).
  The extreme and heterogeneous Qinghai-Tibet Plateau challenges wildlife survival. Przewalski's gazelle (Procapra przewalskii) is confined to the northeastern Plateau around Qinghai Lake, where habitat fragmentation exposes isolated populations to distinct plan…
  europepmc 2026 置信度 0.87
• Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436.
  europepmc 2026 置信度 0.72
• Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives.
  Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the efficacy and safety of cancer treatment. Despite substantial preclinical potential, clinical translation is hindered…
  europepmc 2026 置信度 0.94 medicinecancercomputer sciencetransformative learningneuroscience
• Integrated metabolomic and mRNA transcriptomic analyses reveal key metabolites and genes involved in browning of fresh-cut pitaya.
  europepmc 2026 置信度 0.68
• Electrodeposited Janus collagen membrane with tunable barrier protection, controlled degradation, and synergistic immunomodulation for bone regeneration in complex defects.
  europepmc 2026 置信度 0.68
• Horizontal Gene Transfer and Genome Rearrangements Shape Bacterial Adaptation for Bioremediation.
  europepmc 2026 置信度 0.72
• Genomic evidence of ecological flexibility and cross-niche CRISPR spacerome targeting phage-plasmid hybrids in Latilactobacillus curvatus.
  Background Latilactobacillus curvatus is a lactic acid bacterium with a remarkable ability to persist in diverse niches, including fermented foods and gut. Despite its industrial and potential probiotic relevance, the genomic underpinnings of its cross-niche a…
  europepmc 2026 置信度 0.87
• A V<sub>2</sub>CTx-MXene@f-MWCNTs nanocomposite-reinforced 3D porous graphene-based flexible patch integrated with microfluidic channels for real-time glucose and ketone monitoring in sweat.
  europepmc 2026 置信度 0.68
• Persistent Cardiovascular Burden and Independent Association Among Cancer Survivors in the United States, 2016 to 2024.
  europepmc 2026 置信度 0.68
• Growth differentiation factor-15 and the incidence, bidirectional progression, and risk prediction of atherosclerotic cardiovascular disease and metabolic dysfunction-associated steatotic liver disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.
  europepmc 2026 置信度 0.72
• Applying metabolic control strategies to engineered T cell cancer therapies
  crossref Andrea C. Fox, John Blazeck 2024-10-25T02:52:33Z 置信度 0.66
• Consistent biosynthesis of D-glycerate from variable mixed substrates
  crossref Cynthia Ni, Kristala L.J. Prather 2024-01-05T18:14:20Z 置信度 0.66
• Rethinking 13C-metabolic flux analysis – The Bayesian way of flux inference
  crossref Axel Theorell, Johann F. Jadebeck, Wolfgang Wiechert, Johnjoe McFadden 等 2024-04-04T08:50:19Z 置信度 0.63
• Metabolic engineering of CHO cells towards cysteine prototrophy and systems analysis of the ensuing phenotype
  crossref Laura Greenfield, Mariah Brantley, Pauline Geoffroy, Jeffrey Mitchell 等 2024-06-20T03:21:08Z 置信度 0.66
• -Substituted 3-hydroxy acid production from glucose in Escherichia coli
  crossref K'yal R. Bannister, Kristala L.J. Prather 2024-09-21T06:28:53Z 置信度 0.59
• Corrigendum to “Cyclo-diphenylalanine Production in Aspergillus nidulans through Stepwise Metabolic Engineering” [Metab. Eng. 82 (2024) 147–156]
  crossref Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma 等 2024-03-11T04:49:48Z 置信度 0.66
• Enabling pathway design by multiplex experimentation and machine learning
  crossref Aashutosh Girish Boob, Junyu Chen, Huimin Zhao 2023-11-30T06:57:35Z 置信度 0.61
• Heterologous biosynthesis of betanin triggers metabolic reprogramming in tobacco
  crossref Xun Jiang, Zhuoxiang Zhang, Xiuming Wu, Changmei Li 等 2024-11-04T08:20:24Z 置信度 0.66
• Metabolic engineering of Escherichia coli for high-level production of the biodegradable polyester monomer 2-pyrone-4,6-dicarboxylic acid
  crossref Fengli Wu, Shucai Wang, Dan Zhou, Shukai Gao 等 2024-03-21T23:45:56Z 置信度 0.66
• Engineering peroxisomal surface display for enhanced biosynthesis in the emerging yeast Kluyveromyces marxianus
  crossref Shane Bassett, Jonathan C. Suganda, Nancy A. Da Silva 2024-11-01T10:50:39Z 置信度 0.66
• Creating new-to-nature carbon fixation: A guide
  crossref Helena Schulz-Mirbach, Beau Dronsella, Hai He, Tobias J. Erb 2023-12-29T17:15:09Z 置信度 0.57
• Cutting-edge developments in plastic biodegradation and upcycling via engineering approaches
  crossref Zeinab Rezaei, Amir Soleimani Dinani, Hamid Moghimi 2024-11-28T09:28:50Z 置信度 0.66
• Unlocking lager's flavour palette by metabolic engineering of Saccharomyces pastorianus for enhanced ethyl ester production
  crossref Nicole X. Bennis, Jimme Bieseman, Jean-Marc G. Daran 2024-08-10T06:19:16Z 置信度 0.66
• Metabolic engineering of Acinetobacter baylyi ADP1 for naringenin production
  crossref Kesi Kurnia, Elena Efimova, Ville Santala, Suvi Santala 2024-11-01T01:12:37Z 置信度 0.66
• Extracting and Ranking Metabolic Pathways from Large Metabolic Networks using Graph Theory and Metabolic Flux Analysis
  crossref 2024-06-26T14:39:18Z 置信度 0.63
• Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids
  crossref Genlai Dong, Ying Zhao, Wentao Ding, Shijie Xu 等 2024-02-05T07:21:25Z 置信度 0.66
• Metabolic impact of heterologous protein production in Pseudomonas putida: Insights into carbon and energy flux control
  crossref Philippe Vogeleer, Pierre Millard, Ana-Sofia Ortega Arbulú, Katharina Pflüger-Grau 等 2023-11-02T18:14:32Z 置信度 0.64
• Engineering yeasts to Co-utilize methanol or formate coupled with CO2 fixation
  crossref Yuanke Guo, Rui Zhang, Jing Wang, Ruirui Qin 等 2024-05-15T20:57:26Z 置信度 0.66
• Production of (R)-citramalate by engineered Saccharomyces cerevisiae
  crossref Ryosuke Mitsui, Akihiko Kondo, Tomokazu Shirai 2024-08-10T02:44:10Z 置信度 0.59
• YaliCMulti and YaliHMulti: Stable, efficient multi-copy integration tools for engineering Yarrowia lipolytica
  crossref Mengsu Liu, Junjun Wu, Mingyu Yue, Yang Ning 等 2024-01-13T21:06:20Z 置信度 0.63
• Machine learning predicts system-wide metabolic flux control in cyanobacteria
  crossref Amit Kugler, Karin Stensjö 2024-02-21T12:04:45Z 置信度 0.63
• Engineering and evolution of the complete Reductive Glycine Pathway in Saccharomyces cerevisiae for formate and CO2 assimilation
  crossref Viswanada R. Bysani, Ayesha S. Alam, Arren Bar-Even, Fabian Machens 2023-11-30T06:57:49Z 置信度 0.64
• Engineering a solar formic acid/pentose (SFAP) pathway in Escherichia coli for lactic acid production
  crossref Yajing Zhang, Tao Sun, Linqi Liu, Xupeng Cao 等 2024-04-15T14:09:07Z 置信度 0.63
• Evaluation of enzyme-constrained genome-scale model through metabolic engineering of anaerobic co-production of 2,3-butanediol and glycerol by Saccharomyces cerevisiae
  crossref Gustav Sjöberg, Alīna Reķēna, Matilda Fornstad, Petri-Jaan Lahtvee 等 2024-02-02T00:56:59Z 置信度 0.66
• Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production
  crossref Behnaz Nowrouzi, Pablo Torres-Montero, Eduard J. Kerkhoven, José L. Martínez 等 2023-11-16T00:59:59Z 置信度 0.57
• Efficient utilization of xylose requires CO2 fixation in Synechococcus elongatus PCC 7942
  crossref Shannon R. Pressley, Jake N. Gonzales, Shota Atsumi 2024-09-23T13:09:51Z 置信度 0.63
• A multiscale hybrid modelling methodology for cell cultures enabled by enzyme-constrained dynamic metabolic flux analysis under uncertainty
  crossref Oliver Pennington, Sebastián Espinel Ríos, Mauro Torres Sebastian, Alan Dickson 等 2024-10-30T16:09:09Z 置信度 0.66
• Growth-coupled production of L-isoleucine in Escherichia coli via metabolic engineering
  crossref Nan Lu, Minhua Wei, Xuejing Yang, Yingzi Li 等 2024-10-14T02:26:19Z 置信度 0.66
• Adaptive laboratory evolution and metabolic engineering of Cupriavidus necator for improved catabolism of volatile fatty acids
  crossref Eric C. Holmes, Alissa C. Bleem, Christopher W. Johnson, Gregg T. Beckham 2024-10-28T07:36:52Z 置信度 0.66
• Cyclo-diphenylalanine production in Aspergillus nidulans through stepwise metabolic engineering
  crossref Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma 等 2024-02-20T02:51:56Z 置信度 0.66