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• Generating synthetic genotypes using diffusion models
  SUMMARY: In this paper, we introduce the first diffusion model designed to generate complete synthetic human genotypes, which, by standard protocols, one can straightforwardly expand into full-length, DNA-level genomes. The synthetic genotypes mimic real human…
  openalex Philip Kenneweg, Raghuram Dandinasivara, Xiao Luo, Barbara Hammer 等 2025-04-26 置信度 0.72 ReplicateGenotypeComputer scienceCode (set theory)Genome
• Molecular biology of scrapie-like agents
  A detailed account is given of the nature of the causal agent of scrapie and other transmissible spongiform encephalopathies, with reference to proteinase-resistant protein and its gene, subviral particles and the prion hypothesis.
  openalex Alan Bennett, Christopher R. Birkett, Christopher J. Bostock 1992-06-01 置信度 0.72 ScrapieVirologyBiologyPrion proteinBovine spongiform encephalopathy
• Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions
  Many approaches to the origin of life focus on how the molecules found in biology might be made in the absence of biological processes, from the simplest plausible starting materials. Another approach could be to view the emergence of the chemistry of biology …
  openalex Andrew J. Surman, Marc Rodriguez‐Garcia, Yousef M. Abul‐Haija, Geoffrey J. T. Cooper 等 2019-03-06 置信度 0.72 Function (biology)Biochemical engineeringAbiogenesisComputational biologyComputer science
• Deep-learning-based design of synthetic orthologs of SH3 signaling domains
  openalex Xinran Lian, Niksa Praljak, Subu Subramanian, Sarah Wasinger 等 2024-08-01 置信度 0.72 SH3 domainComputational biologySynthetic biologyGenerative modelBiology
• SYNBIP 2.0: epitopes mapping, sequence expansion and scaffolds discovery for synthetic binding protein innovation
  Synthetic binding proteins (SBPs) represent a pivotal class of artificially engineered proteins, meticulously crafted to exhibit targeted binding properties and specific functions. Here, the SYNBIP database, a comprehensive resource for SBPs, has been signific…
  openalex Yanlin Li, Fengcheng Li, Zixin Duan, Ruihan Liu 等 2024-10-16 置信度 0.72 Protein Data BankEpitopeComputational biologyBiologySequence (biology)
• Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review
  Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, and extending shelf life. The antimicrobial effectiveness of PPs has different molecular and biological reasons, p…
  openalex Luca Rossi, Gabriele Rocchetti, Luigi Lucini, Annalisa Rebecchi 2025-02-10 置信度 0.72 AntimicrobialPolyphenolChemistryBiologyBiochemistry
• Relationships in the age of AI: A review on the opportunities and risks of synthetic relationships to reduce loneliness
  Loneliness is a pressing global health issue, yet traditional interventions often fall short due to scalability limitations and the individualized experiences of loneliness. The rise of generative artificial intelligence (AI) has enabled synthetic relationship…
  openalex Alfio Ventura, Christopher Starke, Francesca Righetti, Nils Köbis 2026-06-25 置信度 0.72 LonelinessPsychologySocial psychology
• Articular cartilage repair and transplantation
  View article in HTML via Journals@Ovid Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author…
  openalex Joseph A. Buckwalter, Henry J. Mankin 1998-08-01 置信度 0.72 TransplantationCartilageContent (measure theory)Articular cartilageMedicine
• Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
  Synthetic cells offer a versatile platform for addressing biomedical and environmental challenges, due to their modular design and capability to mimic cellular processes such as biosensing, intercellular communication, and metabolism. Constructing synthetic ce…
  openalex Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu 2025-01-18 置信度 0.72 SecretionActinSynthetic biologyProteaseDrug delivery
• Recent progress in the synthesis of advanced biofuel and bioproducts
  openalex Brian F. Pfleger, Ralf Takors 2023-02-26 置信度 0.72 BioproductsBiofuelFossil fuelRenewable energyBiochemical engineering
• Roles of microbial interactions in determining the establishment and function of synthetic consortium inoculants for soil applications
  Synthetic microbial consortium inoculants are emerging nature-based solutions for promoting sustainable agriculture and mitigating environmental challenges. However, despite promising results in simpler lab-scale trials, many inoculants fail to establish or pe…
  openalex Yun Xu, Shilva Shrestha, Qing Sun, Ying Wang 2025-01-02 置信度 0.72 Microbial inoculantEcosystemEcosystem servicesPsychological resilienceBiotechnology
• Harnessing plant agriculture to mitigate climate change: A framework to evaluate synthetic biology (and other) interventions
  Plant agriculture contributes substantially to global greenhouse gas emissions, yet it also offers powerful opportunities for climate change mitigation. Here, we focus on how to identify and prioritize synthetic biology strategies to reduce emissions and seque…
  openalex Claudia E. Vickers, Philipp Zerbe 2025-09-19 置信度 0.72 Greenhouse gasSynthetic biologyAgricultureSoftware deploymentBiomass (ecology)
• A Review on the Synthetic Methods for the BODIPY Core
  Boron-dipyrromethene (BODIPY) has attracted extensive research attention in recent years due to its excellent photophysical properties, good chemical stability, and structural tunability, demonstrating broad application in fields such as fluorescence imaging, …
  openalex Ruihan Yang, Hao Guan, Jiayan Jin, Tianran Zheng 等 2025-10-17 置信度 0.72 BODIPYNanotechnologyCore (optical fiber)Computer scienceChemistry
• Review of generative AI for synthetic data generation: a healthcare perspective
  Abstract Generative AI has emerged as a transformative technology in healthcare, enabling the generation of high-fidelity synthetic data for applications such as medical imaging, electronic health records, biomedical signal processing, and drug discovery. The …
  openalex Hafiz Muhammad Waseem, Saif ul Islam, Nicholas Matragkas, Gregory Epiphaniou 等 2025-12-10 置信度 0.72 Generative grammarComputer scienceTransformative learningHealth careArtificial intelligence
• Protein–Polymer Conjugates: Advancing Enzyme Catalysis in Synthetic Chemistry
  Abstract Enzyme catalysis is prominent in chemical synthesis due to its specificity, selectivity, and efficiency. However, enzymes often face challenges, such as inactivation and inhibition in practical applications, and they are also limited by narrow reactio…
  openalex Jingping Ouyang, Jian Li, Changzhu Wu 2024-10-01 置信度 0.72 ChemistryEnzyme catalysisConjugateProtein chemistryBiocatalysis
• Novel synthetic inducible promoters controlling gene expression during water‐deficit stress with green tissue specificity in transgenic poplar
  Synthetic promoters may be designed using short cis-regulatory elements (CREs) and core promoter sequences for specific purposes. We identified novel conserved DNA motifs from the promoter sequences of leaf palisade and vascular cell type-specific expressed ge…
  openalex Yongil Yang, Timothy A. Chaffin, Yuanhua Shao, Vimal Kumar Balasubramanian 等 2024-01-17 置信度 0.72 BiologyTransgenePromoterGeneGene expression
• Crops that feed the world 6. Past successes and future challenges to the role played by maize in global food security
  Maize is one of the most important food crops in the world and, together with rice and wheat, provides at least 30% of the food calories to more than 4.5 billion people in 94 developing countries. In parts of Africa and Mesoamerica, maize alone contributes ove…
  openalex Bekele Shiferaw, B. M. Prasanna, Jon Hellin, Marianne Bänziger 2011-08-23 置信度 0.72 Food securityAgricultureContext (archaeology)LivelihoodGreen Revolution
• Proteogenomic insights into the biology and treatment of pan-melanoma
  Melanoma is one of the most prevalent skin cancers, with high metastatic rates and poor prognosis. Understanding its molecular pathogenesis is crucial for improving its diagnosis and treatment. Integrated analysis of multi-omics data from 207 treatment-naïve m…
  openalex Xiang Hang, Rongkui Luo, Yunzhi Wang, Bing Yang 等 2024-07-22 置信度 0.72 MelanomaImmunotherapyCancer researchMetastatic melanomaImmune system
• Reasons for multiple biologic and targeted synthetic DMARD switching and characteristics of treatment refractory rheumatoid arthritis
  openalex Gregory C McDermott, Michael DiIorio, Yumeko Kawano, Mary Jeffway 等 2024-03-01 置信度 0.72 MedicineRheumatoid arthritisRefractory (planetary science)Biologic AgentsAntirheumatic Agents
• The biology and toxinology of blunt-nosed vipers
  Blunt-nosed vipers (genus Macrovipera) are among the venomous snakes of highest medical relevance in the Palearctic region. Extensive research has been conducted on their venoms, covering toxin composition, biochemistry, function, pathology and biodiscovery. H…
  openalex Ignazio Avella, Maik Damm, Matteo Riccardo Di Nicola, Josephine Dresler 等 2025-06-03 置信度 0.72 BluntBiologyZoologyMedicineSurgery
• Moringa oleifera is a Prominent Source of Nutrients with Potential Health Benefits
  Nowadays, the socioeconomic status has been changed a lot, so people are now more concerned about their life style and health. They have knowledge about the detrimental effects of synthetic products. That is why they are interested in natural products. Utiliza…
  openalex Zahidul Islam, S. M. Rashadul Islam, Faruk Hossen, Kazi Mahtab-Ul-Islam 等 2021-08-10 置信度 0.72 MoringaIngredientHealth benefitsMicronutrientTraditional medicine
• Telomere Maintenance and DNA Repair: A Bidirectional Relationship in Cancer Biology and Therapy
  Telomeres are repetitive DNA sequences at the ends of chromosomes that protect against genomic instability and prevent unwanted DNA damage responses. In most somatic cells, telomeres progressively shorten with each division, limiting cellular lifespan. However…
  openalex Nina Rembiałkowska, Mikołaj Sędzik, Monika Kisielewska, Wiktoria Łuniewska 等 2025-07-09 置信度 0.72 TelomereTelomeraseGenome instabilityDNA repairBiology
• Genetically engineered bacterium: Principles, practices, and prospects
  Advances in synthetic biology and the clinical application of bacteriotherapy enable the use of genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small 'machine factory' in the intestine or other tissues to continuously produce het…
  openalex Yiting Liu, Jing Feng, Hangcheng Pan, Xiuwei Zhang 等 2022-10-13 置信度 0.72 DiseaseGenetically engineeredBiotechnologySynthetic biologyAdjuvant
• Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
  Blood transfusion plays a vital role in modern medicine, but frequent shortages occur. Ex vivo manufacturing of red blood cells (RBCs) from universal donor cells offers a potential solution, yet the high cost of recombinant cytokines remains a barrier. Erythro…
  openalex Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj 等 2025-01-29 置信度 0.72 ErythropoiesisErythropoietinReceptorSignal transductionCell biology
• A framework for complex signal processing via synthetic biological operational amplifiers
  Engineering genetic circuits to process complex biological signals remains a significant challenge due to non-orthogonal signal responses that limit precise control. In this study, we introduce a framework that integrates orthogonal operational amplifiers (OAs…
  openalex Wenjun Cao, Lili Liu, Qing Sun, Yang Shan 等 2025-07-31 置信度 0.72 Computer scienceSignal processingSIGNAL (programming language)Digital signal processingComputer hardware
• Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis
  Ceramide C16 is a sphingolipid detected at high levels in several neurodegenerative disorders, including multiple sclerosis (MS). It can be generated de novo or from the hydrolysis of other sphingolipids, such as sphingomyelin or through the recycling of sphin…
  openalex Mario Amatruda, Damien Maréchal, Mar Gacias, Maureen Wentling 等 2024-11-03 置信度 0.72 CeramideSphingolipidCeramide synthaseMultiple sclerosisBiology
• The Impact of Nanobodies on G Protein–Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents
  openalex David Salom, Arum Wu, Chang C. Liu, Krzysztof Palczewski 2024-08-06 置信度 0.72 Computational biologyG protein-coupled receptorBiologyReceptorBiochemistry
• Preserving the Immune‐Privileged Niche of the Nucleus Pulposus: Safeguarding Intervertebral Discs from Degeneration after Discectomy with Synthetic Mucin Hydrogel Injection
  Intervertebral disc (IVD) herniation is a prevalent spinal disorder, often necessitating surgical intervention such as microdiscectomy for symptomatic relief and nerve decompression. IVDs comprise a gel-like nucleus pulposus (NP) encased by an annulus fibrosus…
  openalex Huan Wang, Song Chen, Zhao Liu, Qingchen Meng 等 2024-08-29 置信度 0.72 Degeneration (medical)NucleusDiscectomyIntervertebral discImmune system
• The Overlapping Biology of Sepsis and Cancer and Therapeutic Implications
  Sepsis and cancer, though distinct in their clinical manifestations, share profound pathophysiological overlaps that underscore their interconnectedness in disease progression and outcomes. Here we discuss the intricate biological mechanisms linking these two …
  openalex Amit Kumar Tripathi, Yogesh Srivastava 2025-05-23 置信度 0.72 Immune systemCancerImmunologyTumor microenvironmentSepsis
• A roadmap toward the synthesis of life
  The synthesis of life from non-living matter has captivated and divided scientists for centuries. This bold goal aims at unraveling the fundamental principles of life and leveraging its unique features, such as its resilience, sustainability, and ability to ev…
  openalex Christine M. E. Kriebisch, Olga Bantysh, Lorena Baranda Pellejero, Andrea Belluati 等 2025-02-06 置信度 0.72 Engineering ethicsPolitical scienceEngineering
• From “synthetic” to defined microbial communities for clearer terminology
  Consortia of microbial isolates, also known as synthetic communities (SynComs), are increasingly used to study and harness microbe-microbe and microbe-host interactions. Since “synthetic” potentially evokes negative connotations, we propose adopting the term “…
  openalex Hanna Koch, Thomas Clavel, Cintia Mayr, Benjamin L. Coltman 等 2026-06-08 置信度 0.72 TerminologyComputational biologyBiologyEvolutionary biologyData science
• Advances in Sweet Corn (Zea mays L. saccharata) Research from 2010 to 2025: Genetics, Agronomy, and Sustainable Production
  Sweet corn (Zea mays L. saccharata) has emerged as a valuable crop not only for its economic potential but also for its role in sustainable food systems due to its high consumer demand and adaptability. As global agricultural systems face increasing pressure f…
  openalex Hajer Mohamed Ibrahim Sidahmed, Attila Vad, János Nagy 2025-05-21 置信度 0.72 Zea maysAgronomyBiology
• Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions
  Systemic autoimmune diseases (SAIDs) affect millions worldwide, presenting significant clinical challenges due to their complex pathogenesis and limited treatment options. Traditional immunosuppressive therapies, while effective, often lack precision, leading …
  openalex Galih Januar Adytia, Henry Sutanto, Laras Pratiwi, Deasy Fetarayani 2025-01-25 置信度 0.72 ImmunologyMedicine
• The Convergence of Biology and Material Science: Biomolecule-Driven Smart Drug Delivery Systems
  Biomolecule-driven smart materials represent a paradigm shift in pharmacology, transitioning drug delivery from a passive process to an active, programmable, and highly specific intervention. These systems, constructed from or functionalized with biological ma…
  openalex Yaqin Hou, Xiaolei Yu 2025-09-28 置信度 0.72 Computer scienceProcess (computing)Synthetic biologyKey (lock)Nanotechnology
• Beyond pigments and perfumes: engineering in the carotenoid and apocarotenoid spectrum, novel enzymes, and synthetic biology strategies
  Carotenoids and apocarotenoids constitute a structurally and functionally sundry class of isoprenoids whose significance extends from photosynthetic light capture and photoprotection to phytohormone signaling, flavor and aroma formation, and emerging biomedica…
  openalex Baradwaj Ravi Gopal, Zhen Wang 2026-01-15 置信度 0.72 PhotoprotectionSynthetic biologyCarotenoidMetabolic engineeringPhytoene
• Microplastic Accumulation and Degradation in Environment via Biotechnological Approaches
  The extensive use of plastics in daily life has led to the generation of huge amounts of plastic waste, which causes an enormous burden on the environment. More than half of the plastic waste ends up in the landfill, and about one-fifth of waste is managed by …
  openalex Sonal Thakur, Shivangi Mathur, Saumya Patel, Biswaranjan Paital 2022-12-12 置信度 0.72 MicroplasticsIncinerationPlastic wasteEnvironmental scienceWaste management
• Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery
  Extracellular vesicles (EVs) have emerged as key intercellular communication and pathogenesis mediators. Parasitic organisms' helminths, cause widespread infections with significant health impacts worldwide. Recent research has shed light on the role of EVs in…
  openalex Abdul Qadeer, Abdul Wajid, Hafiz Abdul Rafey, Saqib Nawaz 等 2024-08-06 置信度 0.72 Extracellular vesiclesHelminth infectionsHelminthsBiologyHelminthiasis
• Conversion of natural cytokine receptors into orthogonal synthetic biosensors
  Synthetic receptors enable bioengineers to build cell-based therapies that perform therapeutic functions in a targeted or conditional fashion to enhance specificity and efficacy. Although many synthetic receptors exist, it remains challenging to generate new r…
  openalex Hailey I. Edelstein, Amparo Cosio, Max L. Ezekiel, William K. Corcoran 等 2025-08-22 置信度 0.72 EctodomainReceptorChimeric antigen receptorCytokine receptorBiology
• Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development
  Circadian rhythms govern cellular metabolism, redox balance, and endocrine signaling in numerous tissues. However, chronic disturbance of these biological rhythms, mediated by modern lifestyle factors including shift work, sleep irregularity, and prolonged lig…
  openalex Rossitza Konakchieva, Mitko Mladenov, Marina Konaktchieva, Iliyana Sazdova 等 2025-06-28 置信度 0.72 Circadian rhythmBiologyCircadian clockProteostasisPyroptosis
• Bone Regeneration: A Review of Current Treatment Strategies
  Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics and oncology. Over the past two decades, significant progress in biomaterials and surgical techniques has …
  openalex Raffaella De Pace, Silvia Molinari, Elisa Mazzoni, Giuseppe Perale 2025-03-08 置信度 0.72 MedicineRegeneration (biology)Clinical PracticeIntensive care medicineMedical physics
• Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species ( S. alata (L.) Roxb. and S. occidentalis (L.) Link)
  ABSTRACT Senna alata (L.) Roxb. and Senna occidentalis (L.) Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed to determine the phytoconstituents, antioxidant, enzyme inhibiti…
  openalex Sakina Yagi, Mehmet Veysi Çetiz, Gökhan Zengin, Kassim Bakar 等 2024-12-22 置信度 0.72 FlavonoidChemistryABTSGlycosideDPPH
• Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids
  DNA and RNA play pivotal roles in life processes by storing and transferring genetic information, modulating gene expression, and contributing to essential cellular machinery such as ribosomes. Dysregulation and mutations in nucleic acid-related processes are …
  openalex Brecht D. Ellenbroek, Jan Kähler, Sophie R. Evers, Sebastian Pomplun 2024-03-08 置信度 0.72 Nucleic acidRNAComputational biologyBiologyDNA
• Organic fluorescent compounds: A review of synthetic strategies and emerging applications
  Organic fluorescent compounds have become integral tools across a wide range of applications because of unique ability to absorb light at one wavelength and emit it at a longer wavelength. It plays a crucial role due to their tunable emission wavelengths and h…
  openalex Sowmya Maiya, Glanish Jude Martis, Nitinkumar S. Shetty, Santosh L. Gaonkar 2025-11-04 置信度 0.72 FluorescenceNanotechnologyBiochemical engineeringMaterials scienceChemistry
• Raman, polarized Raman and ultraviolet resonance Raman spectroscopy of nucleic acids and their complexes
  Abstract Applications of Raman spectroscopy to investigate the molecular constituents of nucleic acids were initiated in the late 1960s and soon thereafter progressed to studies of synthetic and native nucleic acids and complex biological assemblies containing…
  openalex James M. Benevides, Stacy A. Overman, George J. Thomas 2005-04-01 置信度 0.72 Nucleic acidRaman spectroscopyNucleic acid structureResonance Raman spectroscopyChemistry
• Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles
  The synthesis of anisotropic metallic nanoparticles (NPs) has been a field of intense and challenging research in the past decade. In this communication, we report on the reproducible and highly controllable synthesis of monodisperse branched gold nanoparticle…
  openalex Sara Abalde‐Cela, Patricia Taladriz‐Blanco, Marcelo G. de Oliveira, Chris Abell 2018-01-30 置信度 0.72 MicrofluidicsDispersityNanotechnologyMicroreactorNanoparticle
• FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells
  The forkhead protein FoxA1 has functions other than a pioneer factor, in that its depletion brings about a significant redistribution in the androgen receptor (AR) and glucocorticoid receptor (GR) cistromes. In this study, we found a novel function for FoxA1 i…
  openalex Biswajyoti Sahu, Marko Laakso, Päivi Pihlajamaa, Kristian Ovaska 等 2012-12-27 置信度 0.72 FOXA1Androgen receptorLNCaPProstate cancerTranscription factor
• Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics
  Microfluidic production of giant lipid vesicles presents a paradigm-shift in the development of artificial cells. While production is high-throughput and the lipid vesicles are mono-disperse compared to bulk methods, current technologies rely heavily on the ad…
  openalex Naresh Yandrapalli, Julien Petit, Oliver Bäumchen, Tom Robinson 2021-06-29 置信度 0.72 VesicleMicrofluidicsArtificial cellLipid vesiclePulmonary surfactant
• Natural peptides and their synthetic congeners acting against Acinetobacter baumannii through the membrane and cell wall: latest progress
  Acinetobacter baumannii is one of the deadliest Gram-negative bacteria (GNB), responsible for 2–10% of hospital-acquired infections.
  openalex Gautam Kumar 2024-11-20 置信度 0.72 Acinetobacter baumanniiMicrobiologyChemistryBiologyBacteria
• Application of process analytical technology for real-time monitoring of synthetic co-culture bioprocesses
  Synthetic microbial co-cultures can enhance bioprocess performance by division-of-labor strategies that, through spatial segregation of product-pathway modules, circumvent or mitigate negative impacts of the expression of an entire product pathway in a single …
  openalex Nicole A Dambruin, Jack T. Pronk, Marieke E. Klijn 2025-06-06 置信度 0.72 BioprocessBiochemical engineeringPopulationProcess analytical technologyMonitoring and control
• Unravelling the Significance of Extracellular Vesicle‐Associated DNA in Cancer Biology and Its Potential Clinical Applications
  Extracellular vesicles (EVs) play a key role in cell-to-cell communication and have drawn significant attention due to their potential clinical applications. However, much remains to be understood about the biology of EV-associated DNA (EV-DNA). EV-DNA is acti…
  openalex Jamal Ghanam, Kristína Lichá, Venkatesh Kumar Chetty, Ommolbanin Asad Pour 等 2025-03-01 置信度 0.72 BiologyDNAEpigeneticsExtracellular vesiclesComputational biology
• Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
  Biomaterial surface chemistry has profound consequences on cellular and host responses, but the underlying molecular mechanisms remain poorly understood. Using self-assembled monolayers as model biomaterial surfaces presenting well defined chemistries, we demo…
  openalex Benjamin G. Keselowsky, David M. Collard, Andrés J. Garcı́a 2005-04-12 置信度 0.72 IntegrinFibronectinChemistryBiomaterialCell adhesion
• The importance of binding kinetics and drug–target residence time in pharmacology
  A dominant assumption in pharmacology throughout the 20th century has been that in vivo target occupancy-and attendant pharmacodynamics-depends on the systemic concentration of drug relative to the equilibrium dissociation constant for the drug-target complex.…
  openalex Kevin E. Knockenhauer, Robert A. Copeland 2023-05-10 置信度 0.72 PharmacodynamicsDrugPharmacokineticsPharmacologyDrug discovery
• Microalgae-Derived Pigments for the Food Industry
  In the food industry, manufacturers and customers have paid more attention to natural pigments instead of the synthetic counterparts for their excellent coloring ability and healthy properties. Microalgae are proven as one of the major photosynthesizers of nat…
  openalex Han Sun, Yuxin Wang, Yongjin He, Bin Liu 等 2023-01-25 置信度 0.72 PhycobiliproteinFood industryNutraceuticalBiochemical engineeringCarotenoid
• Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors
  Measuring the transduction of electrical signals within neurons is a key capability in neuroscience. Fluorescent voltage sensitive dyes (VSDs) were early tools that complemented classical electrophysiology by enabling the optical recording of membrane potentia…
  openalex Tomas Fiala, David Sulzer, Dalibor Sameš 2025-02-13 置信度 0.72 NeuroscienceSynthetic biologyElectrophysiologyComputer sciencePerspective (graphical)
• Targeting cancer stem cells with CAR-based immunotherapy: biology, evidence, and future directions
  Cancer stem cells (CSCs) are pivotal in tumor initiation, progression, and relapse, underscoring the need for targeted therapies to achieve lasting responses. This review delves into CSC biology, highlighting their tumor-initiating potential demonstrated throu…
  openalex Kaveh Hadiloo, Parsa Mostanadi, Ali Asadzadeh, Siavash Taremi 等 2025-07-28 置信度 0.72 ImmunotherapyCancer stem cellMedicineTumor microenvironmentCancer immunotherapy
• Scientific and technological innovations of wastewater treatment in China
  Abstract The “dual-carbon” strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology innovations. Based on the global climate change and the new policies introduced by China, this paper des…
  openalex Hui Huang, Rui Ma, Hongqiang Ren 2024-03-20 置信度 0.72 ChinaWastewaterBusinessEnvironmental planningEnvironmental science
• PIONEER: A periplasmic display platform for synthetic biology-based screening of genetically encoded protein regulators
  Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present Periplasmic dIsplay Of geNetically Encoded rEgulatoRs (PIONEER), a modular platform that localizes peptides, proteins,…
  openalex Jacob B. Rowe, Kyutae Lee, Daniel G. Isom 2025-11-21 置信度 0.72 Periplasmic spaceChaperone (clinical)Ligand (biochemistry)Directed Molecular EvolutionBiology
• Availability: A Metric for Nucleic Acid Strand Displacement Systems
  DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach…
  openalex Xiaoping Olson, Shohei Kotani, Jennifer E. Padilla, Natalya Hallstrom 等 2016-02-15 置信度 0.72 Leakage (economics)ScalabilitySynthetic biologyNucleic acidBiochemical engineering
• From Delaunay triangulation to topological data analysis: generation of more realistic synthetic power grid networks
  Abstract Assessing novel methods for increasing power system resilience against cyber-physical hazards requires real power grid data or high-quality synthetic data. However, for security reasons, even basic connection information for real power grid data are n…
  openalex Asim Kumer Dey, Stephen J. Young, Yulia R. Gel 2023-05-22 置信度 0.72 Delaunay triangulationComputer scienceBenchmark (surveying)Metric (unit)Data mining
• Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization
  Reflecting on the diversity of the natural world, Darwin famously observed that "from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved." However, the examples that we are able to observe in nature are a con…
  openalex Zhejing Xu, Chih‐Chia Chang, Scott M. Coyle 2025-02-12 置信度 0.72 Synthetic biologyTransformative learningLiving systemsDiversity (politics)Biological evolution
• A synthetic genomics-based African swine fever virus engineering platform
  African swine fever (ASF) is a deadly viral disease in domestic pigs that has a large global economic impact for the swine industry. It is present in Africa, Europe, Asia, and in the Caribbean island of Hispaniola. There are no effective treatments or broadly …
  openalex Walter Fuchs, Nacyra Assad-Garcia, Hussein M. Abkallo, Yong Xue 等 2025-03-26 置信度 0.72 African swine fever virusGenomeCRISPRCas9Virus
• Natural products for cancer chemotherapy
  For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the terrestrial and marine environments. The microbes serve as a major source of natural products with anti…
  openalex Arnold L. Demain, Preeti Vaishnav 2010-11-18 置信度 0.72 CancerCancer treatmentChemotherapeutic drugsCancer therapyCancer chemotherapy
• Metabolic bottlenecks of Pseudomonas taiwanensis VLB120 during growth on d-xylose via the Weimberg pathway
  crossref Philipp Nerke, Jonas Korb, Frederick Haala, Georg Hubmann 等 2024-06-06T06:33:01Z 置信度 0.70
• Metabolic engineering of artificially modified transcription factor SmMYB36-VP16 for high-level production of tanshinones and phenolic acids
  crossref Entong Jia, He Li, Fang He, Xiaoyu Xu 等 2024-08-22T22:45:35Z 置信度 0.70
• A machine learning framework for extracting information from biological pathway images in the literature
  crossref Mun Su Kwon, Junkyu Lee, Hyun Uk Kim 2024-09-02T20:40:51Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Genetically encoded biosensors for the circular plastics bioeconomy
  crossref Micaela Chacón, Neil Dixon 2024-11-28T17:21:24Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• KETCHUP: Parameterizing of large-scale kinetic models using multiple datasets with different reference states
  crossref Mengqi Hu, Patrick F. Suthers, Costas D. Maranas 2024-02-07T09:23:15Z 置信度 0.70
• Review for "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids"
  crossref 2024-10-04T17:14:55Z 置信度 0.70
• Revealing the dynamics and mechanisms of bacterial interactions in cheese production with metabolic modelling
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• Metabolic flux analysis and metabolic engineering for polyhydroxybutyrate (PHB) production
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• Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica
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