主题图谱 / systems biology

systems biology

GeneTech 知识引擎共收录 144 篇相关科研实体，横跨 16 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

年度产出趋势

代表性文献（按质量分排序，前 60 条）

• Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases
  2026 · 生物计算 · Organ cross-talk, also known as the organ axis or organ interaction network, plays a vital role in maintaining physiological homeostasis and responding to environmental stimuli. This review comprehensively integrates cut…
• AlphaFold3: An Overview of Applications and Performance Insights
  2025 · AI 安全与对齐 · AlphaFold3, the latest release of AlphaFold developed by Google DeepMind and Isomorphic Labs, was designed to predict protein structures with remarkable accuracy. AlphaFold3 enhances our ability to model not only single …
• The Advancement and Application of the Single-Cell Transcriptome in Biological and Medical Research
  2024 · 生物计算 · Single-cell RNA sequencing technology (scRNA-seq) has been steadily developing since its inception in 2009. Unlike bulk RNA-seq, scRNA-seq identifies the heterogeneity of tissue cells and reveals gene expression changes …
• Design patterns of biological cells
  2024 · 生物计算 · Design patterns are generalized solutions to frequently recurring problems. They were initially developed by architects and computer scientists to create a higher level of abstraction for their designs. Here, we extend t…
• Applications of synthetic biology in medical and pharmaceutical fields
  2023 · 生物计算 · Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological buildin…
• Applications of synthetic biology in medical and pharmaceutical fields
  2023 · 合成生物与生物制造 · Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological buildin…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · AI Agent 生态 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · AI Agent 生态 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · AI Agent 生态 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity
  2026 · AI Agent 生态 · An Irreducible Dynamical Grammar for Minimal Living Systems Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, and Grounded Heredity Theoretical definitions of minimal life have historically bifurcated int…
• An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity
  2026 · AI Agent 生态 · An Irreducible Dynamical Grammar for Minimal Living Systems Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, and Grounded Heredity Theoretical definitions of minimal life have historically bifurcated int…
• Technical Specifications, Operational Workflows, and Methodological Frameworks of Gemini-LifeScientist
  2026 · AI 驱动科学发现 · ⚡ TL;DR: This document defines the rigorous evidentiary hierarchies, data integration standards, and analytical pipelines governing the Gemini-LifeScientist expert system for high-fidelity biomedical research. Abstract: …
• Technical Specifications, Operational Workflows, and Methodological Frameworks of Gemini-LifeScientist
  2026 · AI 驱动科学发现 · ⚡ TL;DR: This document defines the rigorous evidentiary hierarchies, data integration standards, and analytical pipelines governing the Gemini-LifeScientist expert system for high-fidelity biomedical research. Abstract: …
• <b>CAIS Architecture &amp; Sal-Meter Technical Snapshot v1.0 </b>
  2026 · 生物计算 · This file is part of the Sal-Meter CAIS Figshare starter pack(System Overview v1.0, Technical Governance Snapshot v2.0, CAIS Architecture &amp; Technical Snapshot v1.0),a non-canonical helper set for laboratories conside…
• <b>CAIS Architecture &amp; Sal-Meter Technical Snapshot v1.0</b>A minimal, buildable CAIS stack and implementation checklist for Sal-Meter engineering teams (Figshare 3-pack: System Overview, Governance Snapshot, Technical Snapshot).
  2026 · 生物计算 · This file is part of the Sal-Meter CAIS Figshare starter pack(System Overview v1.0, Technical Governance Snapshot v2.0, CAIS Architecture &amp; Technical Snapshot v1.0),a non-canonical helper set for laboratories conside…
• CUQDyn1_Plus: Hybrid Conformal–Gaussian Uncertainty Quantification for Partially Observed ODE Systems
  2026 · 生物计算 · Overview CUQDyn1_Plus is a MATLAB toolbox for parameter estimation and uncertainty quantification (UQ) in ordinary differential equation (ODE) models where only a subset of state variables are experimentally observed. It…
• CUQDyn1_Plus: Hybrid Conformal–Gaussian Uncertainty Quantification for Partially Observed ODE Systems
  2026 · 生物计算 · Overview CUQDyn1_Plus is a MATLAB toolbox for parameter estimation and uncertainty quantification (UQ) in ordinary differential equation (ODE) models where only a subset of state variables are experimentally observed. It…
• Systems Biology in Biomedicine: Decoding Complex Diseases Through Network-Based Approaches
  2026 · 医疗人工智能 · This extensive review details the transformative impact of systems biology and network medicine on understanding and treating complex human diseases. Moving beyond traditional reductionist paradigms that focus on single …
• Systems Biology in Biomedicine: Decoding Complex Diseases Through Network-Based Approaches
  2026 · 医疗人工智能 · This extensive review details the transformative impact of systems biology and network medicine on understanding and treating complex human diseases. Moving beyond traditional reductionist paradigms that focus on single …
• The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility
  2026 · 数字孪生 · Current neurological diagnostic frameworks rely on probabilistic biomarkers that provide a static "snapshot" of pathology but lack the temporal resolution required to predict clinical onset. This research presents a dete…
• The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility
  2026 · 数字孪生 · Current neurological diagnostic frameworks rely on probabilistic biomarkers that provide a static "snapshot" of pathology but lack the temporal resolution required to predict clinical onset. This research presents a dete…
• The Bounded Corridor: A Regime Theory of Biological Persistence
  2026 · 地外科学 · Abstract The Bounded Corridor develops a candidate regime theory of biological persistence around a foundational question: what licenses sameness through biological change? It begins from the claim that persistence canno…
• The Bounded Corridor: A Regime Theory of Biological Persistence
  2026 · 地外科学 · Abstract The Bounded Corridor develops a candidate regime theory of biological persistence around a foundational question: what licenses sameness through biological change? It begins from the claim that persistence canno…
• An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity
  2026 · 地外科学 · An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity Overview:This theoretical preprint establishes a unified,…
• An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity
  2026 · 地外科学 · An Irreducible Dynamical Grammar for Minimal Living Systems: Synthesizing Non-Equilibrium Thermodynamics, Autopoietic Closure, Biosemiotics, and Grounded Heredity Overview:This theoretical preprint establishes a unified,…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 基因技术工具 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 基因技术工具 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 基因技术工具 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 基因技术工具 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Systems Biology in Biomedicine: Decoding Complex Diseases Through Network-Based Approaches
  2026 · 基因技术工具 · This extensive review details the transformative impact of systems biology and network medicine on understanding and treating complex human diseases. Moving beyond traditional reductionist paradigms that focus on single …
• Systems Biology in Biomedicine: Decoding Complex Diseases Through Network-Based Approaches
  2026 · 基因技术工具 · This extensive review details the transformative impact of systems biology and network medicine on understanding and treating complex human diseases. Moving beyond traditional reductionist paradigms that focus on single …
• Technical Specifications, Operational Workflows, and Methodological Frameworks of Gemini-LifeScientist
  2026 · 生命科学 · ⚡ TL;DR: This document defines the rigorous evidentiary hierarchies, data integration standards, and analytical pipelines governing the Gemini-LifeScientist expert system for high-fidelity biomedical research. Abstract: …
• Technical Specifications, Operational Workflows, and Methodological Frameworks of Gemini-LifeScientist
  2026 · 生命科学 · ⚡ TL;DR: This document defines the rigorous evidentiary hierarchies, data integration standards, and analytical pipelines governing the Gemini-LifeScientist expert system for high-fidelity biomedical research. Abstract: …
• From Intervention to Non-Interference: A Systems-Level Perspective on Biological Reorganization
  2026 · 生命科学 · A systems-level conceptual perspective proposing that stable biological change in complex adaptive systems may emerge not primarily through targeted intervention, but through the reduction of interference within coherent…
• From Intervention to Non-Interference: A Systems-Level Perspective on Biological Reorganization
  2026 · 生命科学 · A systems-level conceptual perspective proposing that stable biological change in complex adaptive systems may emerge not primarily through targeted intervention, but through the reduction of interference within coherent…
• Mechanistic ODE model of neutrophil-mediated DIC (code and data) — v1.0.2
  2026 · 生命科学 · Mechanistic ODE model of neutrophil-mediated disseminated intravascular coagulation — code and data (v1.0.2) This deposit contains the complete source code, reconstructed experimental dataset, analysis scripts, and repro…
• Mechanistic ODE model of neutrophil-mediated DIC (code and data) — v1.0.0
  2026 · 生命科学 · Mechanistic ODE model of neutrophil-mediated disseminated intravascular coagulation — code and data (v1.0.0) This deposit contains the complete source code, reconstructed experimental dataset, analysis scripts, and repro…
• Mechanistic ODE model of neutrophil-mediated DIC (code and data) — v1.0.2
  2026 · 生命科学 · Mechanistic ODE model of neutrophil-mediated disseminated intravascular coagulation — code and data (v1.0.2) This deposit contains the complete source code, reconstructed experimental dataset, analysis scripts, and repro…
• Mechanistic ODE model of neutrophil-mediated DIC (code and data) — v1.0.1
  2026 · 生命科学 · Mechanistic ODE model of neutrophil-mediated disseminated intravascular coagulation — code and data (v1.0.1) This deposit contains the complete source code, reconstructed experimental dataset, analysis scripts, and repro…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 生命科学 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 生命科学 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 生命科学 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Sheaf-Theoretic Approach to Multiscale Pathophysiological Mapping: A Topological Framework for Clinical Data Integration and Disease Modeling
  2026 · 量子材料 · English (opzionale, ma raccomandato per Zenodo): This preprint introduces a methodological proposal for the systematic mapping of the human organism and its pathologies using the mathematical formalism of Sheaf Theory [1…
• Building a Systems-Level Understanding of Vibrio natriegens for Bioengineering
  2026 · 合成生物与生物制造 · Nature has an impressive track record of finding creative solutions to problems. These remarkable strategies have presented scientists with many of the best tools for biotechnology, from molecules that target debilitatin…
• Systems vs Synthetic Biology: A Strategic Guide for Next-Generation Drug Discovery
  2026 · 合成生物与生物制造 · This comprehensive guide explores the synergistic relationship between systems biology and synthetic biology, two transformative disciplines reshaping biomedical research, biomanufacturing, and therapeutic development. S…
• Systems vs Synthetic Biology: A Strategic Guide for Next-Generation Drug Discovery
  2026 · 合成生物与生物制造 · This comprehensive guide explores the synergistic relationship between systems biology and synthetic biology, two transformative disciplines reshaping biomedical research, biomanufacturing, and therapeutic development. S…
• MODELAGEM COMPUTACIONAL DA RESOLUÇÃO INFLAMATÓRIA MEDIADA POR TREGS EM CULTURAS 3D DE TECIDOS REGENERATIVOS: UMA ABORDAGEM COM PINNS E IMUNOMETABOLISMO
  2026 · 合成生物与生物制造 · Esta pesquisa apresenta uma estrutura computacional avançada destinada à investigação dos mecanismos de resolução inflamatória em tecidos regenerativos tridimensionais, integrando conceitos de imunologia, imunometabolism…
• MODELAGEM COMPUTACIONAL DA RESOLUÇÃO INFLAMATÓRIA MEDIADA POR TREGS EM CULTURAS 3D DE TECIDOS REGENERATIVOS: UMA ABORDAGEM COM PINNS E IMUNOMETABOLISMO
  2026 · 合成生物与生物制造 · Esta pesquisa apresenta uma estrutura computacional avançada destinada à investigação dos mecanismos de resolução inflamatória em tecidos regenerativos tridimensionais, integrando conceitos de imunologia, imunometabolism…
• Understanding Biological Life and the Evolution of the Universe through Universal Laws: Integrating Science, Philosophy, and Practical Applications
  2025 · AI 安全与对齐 · Understanding Biological Life and the Evolution of the Universe through Universal Laws: Integrating Science, Philosophy, and Practical Applications Author: Angelito Malicse Date: August 2025 Abstract This paper explores …
• The Liver Was the First Brain: The Liver–Brain Co-evolution Hypothesis (LBC Hypothesis)
  2025 · AI 驱动科学发现 · This paper (idea) let the Author to the following during December 2025 and January 2026 that you might find interesting. Life as a Phase Transition — Series Overview Foundational framework A. An Architectural Origin of O…
• Identity as a Coherence Interface_ A Structural Theory of Selfhood in Biological Phase Systems
  2025 · 脑科学 · Supersession Note — April 30, 2026 This CODES-era work is an exploratory predecessor and is no longer the canonical statement of the author’s program. It has been superseded by the identity-persistence stack: Universal I…
• Identity as a Coherence Interface_ A Structural Theory of Selfhood in Biological Phase Systems
  2025 · 脑科学 · Supersession Note — April 30, 2026 This CODES-era work is an exploratory predecessor and is no longer the canonical statement of the author’s program. It has been superseded by the identity-persistence stack: Universal I…
• Identity as a Coherence Interface_ A Structural Theory of Selfhood in Biological Phase Systems
  2025 · 生命科学 · Supersession Note — April 30, 2026 This CODES-era work is an exploratory predecessor and is no longer the canonical statement of the author’s program. It has been superseded by the identity-persistence stack: Universal I…
• Identity as a Coherence Interface_ A Structural Theory of Selfhood in Biological Phase Systems
  2025 · 生命科学 · Supersession Note — April 30, 2026 This CODES-era work is an exploratory predecessor and is no longer the canonical statement of the author’s program. It has been superseded by the identity-persistence stack: Universal I…
• Pathological Operational Closure: The Thermodynamics of Addiction as a Parasitic Subsystem
  2025 · 合成生物与生物制造 · Abstract Standard neurobiological models often treat addiction as a failure of cognitive control (a “broken brake”) or a maladjusted prediction machinery. We propose a novel systems biology framework, grounded in the Fre…
• Pathological Operational Closure: The Thermodynamics of Addiction as a Parasitic Subsystem
  2025 · 合成生物与生物制造 · Abstract Standard neurobiological models often treat addiction as a failure of cognitive control (a “broken brake”) or a maladjusted prediction machinery. We propose a novel systems biology framework, grounded in the Fre…
• Metabolic Weather: Volume I — From Seed to Rhythm
  2025 · 合成生物与生物制造 · This work introduces the concept of Metabolic Weather — a transdisciplinary framework linking metabolism, immunity, and consciousness into a unified field of rhythmic self-organization.Drawing from systems biology, psych…
• Metabolic Weather: Volume I — From Seed to Rhythm
  2025 · 合成生物与生物制造 · This work introduces the concept of Metabolic Weather — a transdisciplinary framework linking metabolism, immunity, and consciousness into a unified field of rhythmic self-organization.Drawing from systems biology, psych…
• <b>The future of plant tissue culture biotechnology in dermocosmetics:</b> <i>Innovations in sustainable skincare</i>
  2025 · 合成生物与生物制造 · This article explores the role of plant tissue culture biotechnology in developing next-generation dermocosmetic products that are effective, sustainable, and ethically produced. It details how controlled in vitro cultiv…
• Preliminary analysis suggests difficulty in profiling for microbial 16S rRNA gene in human stool metagenomes
  2024 · 生物计算 · Shotgun metagenomics is one of the main approaches for profiling microbial genes in different habitats. This work attempts to profile 16S rRNA genes of different common gastrointestinal microbes in human stool metagenome…

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