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• Intracellular biosensors by functional nanomaterial-integrated CRISPR technologies for real-time molecular sensing.
  CRISPR technology, originally developed as a genome-editing tool, has recently emerged as a powerful platform for intracellular biosensing. By harnessing the programmability and target specificity of CRISPR-associated proteins, such as Cas9, Cas12, and Cas13, …
  europepmc 2026 置信度 0.87
• Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.
  Anoctamin 2 (ANO2, TMEM16B) is a calcium-activated chloride channel best known for its role in sensory neurons, yet its expression in multiple brain regions associated with dopamine-related signaling, including the prefrontal cortex, striatum, substantia nigra…
  europepmc 2026 置信度 0.87
• FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing.
  Clinical translation of CRISPR/Cas9 therapeutics is challenged by inefficient cytosolic delivery and toxicity issues associated with viral vectors and nanoparticle-based carriers. To overcome these concerns, herein we report a lipid-silica hybrid nanoparticle …
  europepmc 2026 置信度 0.87
• Reframing fruit biofortification for sustainable micronutrient security: from crop innovation to nutritional impact.
  Micronutrient malnutrition, commonly referred to as "hidden hunger, " remains a persistent global health challenge, particularly in regions with limited dietary diversity. Although agricultural intensification has substantially improved caloric availability, i…
  europepmc 2026 置信度 0.87
• WormTagDB: a systematic survey of endogenously tagged proteins in Caenorhabditis elegans and roadmap toward the tagged proteome.
  Endogenous protein tagging in Caenorhabditis elegans enables the direct visualization and manipulation of proteins in vivo, providing native readouts of expression, localization, and dynamics. No coordinated effort currently exists to comprehensively tag prote…
  europepmc 2026 置信度 0.87
• Genome-Wide CRISPR/Cas9 Screening Identifies Modulators of THZ1 Response in Acute Myeloid Leukemia.
  Background/Objectives: Acute myeloid leukemia (AML) remains in need of more broadly effective therapeutic strategies. THZ1, a covalent CDK7 inhibitor, has shown anti-leukemic activity in AML, but the mechanism underlying its response remains incompletely defin…
  europepmc 2026 置信度 0.87
• GmRPS5 Promoter-Driven CRISPR/LbCas12a Efficiently Generates Soybean Sextuple Mutants.
  europepmc 2026 置信度 0.76
• Genome editing and regeneration pipeline for engineering disease resistance in tomato using CRISPR/Cas9.
  CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/Cas9)-based genome editing has emerged as a powerful tool for developing disease-resistant crops. Here, we present a comprehensive and reproducible protocol for applying CRISPR/Cas9 genome …
  europepmc 2026 置信度 0.87
• Single-Cell CRISPR: An Efficient Strategy for Decoding Plant Cis-Regulatory Complexity.
  The generation of complex traits involves the coordinated interplay of multiple gene networks. Elucidating the function of transcriptional cis-regulatory elements (CREs) in regulating gene expression is crucial for understanding complex regulatory pathways and…
  europepmc 2026 置信度 0.87
• Functional characterization of Hsk1 and Chit1 genes in the virulence of Metarhizium guizhouense Xct1 via CRISPR-Cas9-mediated gene editing.
  Background The entomopathogenic fungus Metarhizium guizhouense Xct1 exhibits high virulence against early-instar Spodoptera frugiperda larvae (>90% mortality in preliminary studies), yet the molecular mechanisms, particularly the roles of key genes such as the…
  europepmc 2026 置信度 0.87
• A Pangenome Framework Reveals Conserved Pathogenicity-Associated Biosynthetic Gene Clusters in Fusarium equiseti, a Root Rot Pathogen of Panax notoginseng.
  Panax notoginseng (Chinese ginseng, sanqi) is an economically and medicinally important herb whose cultivation is increasingly threatened by destructive soilborne root rot. Although Fusarium species represent the dominant pathogens in this disease complex, the…
  europepmc 2026 置信度 0.87
• Cas9/sgRNA-mediated genome editing of citrus via mature tissue transformation enables both high-efficacy genome editing and early flowering.
  CRISPR genome editing has shown tremendous potential in genetic improvement of citrus. So far, citrus genome editing has been conducted using juvenile tissues resulting in genome-edited citrus plants that require multiple years before they can produce flowers …
  europepmc 2026 置信度 0.87
• Engineering delivery platforms for CRISPR-Cas and their applications in healthcare, agriculture and beyond.
  Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have transformed genome editing through unprecedented precision, and next-generation variants (base and prime editors) further enhance specificity by enabling targeted nucleotide ch…
  europepmc 2026 置信度 0.87
• Plant resistance: scientific basis and latest research progress.
  Plant resistance to insects and diseases is a cornerstone of sustainable agriculture, reducing dependence on chemical pesticides and enhancing long-term crop resilience. Plant resistance is a suite of constitutive and inducible defenses, including structural b…
  europepmc 2026 置信度 0.87
• Knockout of Ku70 and Ku80 elevates homology-directed repair efficiency in Plutella xylostella.
  The suppression of Ku70 and Ku80 has been verified to increase homology-directed repair (HDR) efficiency in fruit fly, silkworm and mosquito, but not in other insects. In this study, PxKu70 and PxKu80 were identified from the Plutella xylostella genome. Domain…
  europepmc 2026 置信度 0.87
• Precision breeding in a changing climate: unlocking resilience through omics and gene editing.
  Climate change, rising global food demand, and shrinking resources require transformative innovations in crop breeding. This review outlines recent advances in new breeding technologies (NBTs), including molecular markers, genome-wide association studies (GWAS…
  europepmc 2026 置信度 0.87
• CRISPR-Based Approaches to Engineer Nonmodel Bacteria for Bioproduction and Biotherapeutics.
  Microbial diversity encompasses vast genetic and functional capacities, with immense potential for biotechnological applications. Yet, most biotechnological advances have been confined to a narrow set of model organisms, leaving the broader repertoire of nonmo…
  europepmc 2026 置信度 0.87
• CRISPR Technology: Transforming the Future of Medicine and Diagnostics.
  In this report, we examine the extensive research landscape of CRISPR with an emphasis on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up-to-date scientific information consisting of more than 53,000 publications encompass…
  europepmc 2025 置信度 0.87
• The regulatory frameworks surrounding CRISPR-edited papaya and their impact on international commerce.
  The papaya tree (Carica papaya L.), native to the Americas, is cultivated in tropical regions and holds substantial economic importance, with an estimated export volume of 365 000 t in 2023. However, diseases caused by viruses, fungi, bacteria, and nematodes c…
  europepmc 2026 置信度 0.87
• The Role of Two Glycoalkaloid Metabolism Genes in α-Tomatine Biosynthesis and Basal Defence in Tomato.
  Steroidal glycoalkaloids and saponins are plant cholesterol-based steroid metabolites with antimicrobial activities and potential pharmacological value. The saponin uttroside B from black nightshade (Solanum nigrum) plays an important role in defence against h…
  europepmc 2026 置信度 0.87
• Understanding the public's intention to adopt CRISPR-Cas9: the effect of beliefs, knowledge, and innovativeness.
  CRISPR-Cas9 is a gene editing technology with wide-ranging medical potential and significant ethical implications. This study examined how personality traits, familiarity with CRISPR, knowledge about CRISPR, and beliefs concerning its applications are connecte…
  europepmc 2026 置信度 0.87
• Nano-enabled plant genetic engineering for stress resilience: current advances and future directions.
  Plant productivity and food security are increasingly threatened by abiotic and biotic stresses intensified by climate change. Plant genetic engineering offers powerful solutions to enhance stress resilience; however, conventional transformation approaches rem…
  europepmc 2026 置信度 0.87
• INDETERMINATE DOMAIN 9 negatively regulates rice crown root development.
  Introduction Crown root is an important part of rice root system, and the development of crown root is regulated by a series of plant-specific transcription factors. As a significant plant-specific transcription factor family, the relationship between IDD and …
  europepmc 2026 置信度 0.87
• Research progress on emerging and important Tick-Borne pathogens.
  Ticks are important vector arthropods, which can carry and transmit a variety of pathogenic microorganisms, and pose a serious threat to global public health. This study reviews the research progress of the main and emerging tick-borne pathogens, such as Lyme …
  europepmc 2026 置信度 0.87
• itu-kgenome: ITU Pass-2 Development Toolkit #30 (Genomics Information Theory K_genome)
  Copyright (C) 2026 Munehiro Terada. Licensed under CC-BY-4.0. ITU Pass-2 Development Research artifact #30. Python toolkit implementing K_genome modular Hamiltonian on H_genome = H_dna ⊗ H_chromatin ⊗ H_transcript ⊗ H_variation ⊗ H_editing, with four operation…
  datacite Terada, Munehiro 2026 置信度 0.79 information-theoretic unificationITUK_genomeSanger 1977Nobel 1980 Sanger Berg Gilbert
• itu-kgenome: ITU Pass-2 Development Toolkit #30 (Genomics Information Theory K_genome)
  Copyright (C) 2026 Munehiro Terada. Licensed under CC-BY-4.0. ITU Pass-2 Development Research artifact #30. Python toolkit implementing K_genome modular Hamiltonian on H_genome = H_dna ⊗ H_chromatin ⊗ H_transcript ⊗ H_variation ⊗ H_editing, with four operation…
  datacite Terada, Munehiro 2026 置信度 0.79 information-theoretic unificationITUK_genomeSanger 1977Nobel 1980 Sanger Berg Gilbert
• A World-First Discovery of Energy Modulation Theory (EMT): Computational Companion and Scale-Free Implications Across Scales (Version V3)
  Author’s Note: Declaration and Disclaimer This manuscript is a hypothesis-generating, speculative, and preliminary research work spanning multiple scientific disciplines. The core ideas are solely those of the author. The whole content of this manuscript was g…
  datacite ALAM, DR SEIKH JAHANGIR 2026 置信度 0.76 Energy Modulation Theory, EMT, active matter, dissipative structures, nonlinear modulation, history dependence, stochastic differential equations, scale-free systems, persistent inequality, computational companion
• Gene Editing and CRISPR: 3 Ways We Are Rewriting the Human Genome Right Now — And the 3 Questions No One Is Asking
  This article examines three ways CRISPR gene editing is currently rewriting the human genome and three questions that the speed of this technology's development has so far outrun. The scientific context covers: the FDA approval of Casgevy (December 2023) as th…
  datacite Rout, Narayan 2026 置信度 0.79 Gene editing and CRISPRCRISPR gene editing human genomeCasgevy sickle cell disease FDA approval 2023baby KJ personalised CRISPR therapy NEJM 2025He Jiankui germline editing ethics
• Gene Editing and CRISPR: 3 Ways We Are Rewriting the Human Genome Right Now — And the 3 Questions No One Is Asking
  This article examines three ways CRISPR gene editing is currently rewriting the human genome and three questions that the speed of this technology's development has so far outrun. The scientific context covers: the FDA approval of Casgevy (December 2023) as th…
  datacite Rout, Narayan 2026 置信度 0.79 Gene editing and CRISPRCRISPR gene editing human genomeCasgevy sickle cell disease FDA approval 2023baby KJ personalised CRISPR therapy NEJM 2025He Jiankui germline editing ethics
• Genetic Engineering, Clinical Translation, and Ethical Access
  Abstract Genetic engineering has moved from experimental promise into regulated clinical treatment, but the meaning of that transition is more complicated than a scientific milestone. This paper examines the clinical translation of CRISPR-based therapy through…
  datacite Okoye, Ogochukwu Ifeanyi 2026 置信度 0.77 medicinehealth careneurosciencebiotechnologybiology
• Genetic Engineering, Clinical Translation, and Ethical Access
  Abstract Genetic engineering has moved from experimental promise into regulated clinical treatment, but the meaning of that transition is more complicated than a scientific milestone. This paper examines the clinical translation of CRISPR-based therapy through…
  datacite Okoye, Ogochukwu Ifeanyi 2026 置信度 0.77 medicinehealth careneurosciencebiotechnologybiology
• ITU Tier 1+ #29: Developmental Biology (K_dev)
  Tier 1+ Pass-1.5 paper 29 of 45. ITU-derived developmental biology on zygote + gastrulation + morphogenesis + differentiation + organogenesis. Defines K_dev = -log ρ_dev as the operator-algebraic modular Hamiltonian on H_zygote ⊗ H_gastrulation ⊗ H_morphogenes…
  datacite Terada, Munehiro 2026 置信度 0.79 information-theoretic unificationITUK_devmodular HamiltonianPass-1.5 Tier 1+ #29
• ITU Tier 1+ #29: Developmental Biology (K_dev)
  Tier 1+ Pass-1.5 paper 29 of 45. ITU-derived developmental biology on zygote + gastrulation + morphogenesis + differentiation + organogenesis. Defines K_dev = -log ρ_dev as the operator-algebraic modular Hamiltonian on H_zygote ⊗ H_gastrulation ⊗ H_morphogenes…
  datacite Terada, Munehiro 2026 置信度 0.79 information-theoretic unificationITUK_devmodular HamiltonianPass-1.5 Tier 1+ #29
• ITU and Pharmacology: A Single-Axiom View of Drug Discovery, Receptor Pharmacology, ADME, Pharmacogenomics, Antibody Medicines, Vaccines and Immunotherapy, AI Drug Design, and FDA Regulation — Pass-1 Extension Paper #2, Block B 6/6 COMPLETE
  This is Tier 1 paper #32 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the SECOND paper of Pass-1 extension and completes Block B (life sciences) to 6/…
  datacite Terada, Munehiro 2026 置信度 0.79 PharmacologypharmacologyDrug discoveryDrug Discoverydrug discovery
• ITU and Pharmacology: A Single-Axiom View of Drug Discovery, Receptor Pharmacology, ADME, Pharmacogenomics, Antibody Medicines, Vaccines and Immunotherapy, AI Drug Design, and FDA Regulation — Pass-1 Extension Paper #2, Block B 6/6 COMPLETE
  This is Tier 1 paper #32 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the SECOND paper of Pass-1 extension and completes Block B (life sciences) to 6/…
  datacite Terada, Munehiro 2026 置信度 0.79 PharmacologypharmacologyDrug discoveryDrug Discoverydrug discovery
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL Tier 1 paper of Pass-1, following #26 I…
  datacite Terada, Munehiro 2026 置信度 0.79 GenomicsgenomicsHuman Genome ProjectHuman Genome ProjectCRISPR
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL Tier 1 paper of Pass-1, following #26 I…
  datacite Terada, Munehiro 2026 置信度 0.79 GenomicsgenomicsHuman Genome ProjectHuman Genome ProjectCRISPR
• Engineering Trust in Gene Therapy: Designing a Stakeholder-Aligned Ethical Risk Dashboard; Constructing Legitimacy in Gene Therapy: An Actor-Network Theory Analysis of the Jesse Gelsinger Case
  Gene therapy represents a transformative biomedical advancement that intervenes at the genetic level, treating or even curing disease at its root. It holds remarkable potential for patients with rare and degenerative chronic conditions such as spinal muscular …
  datacite Syptak, Christopher 2026 置信度 0.77 SAERDGene TherapyJesse GelsingerActor Network Theory
• Epigenetic gene regulation is controlled by distinct regulatory complexes utilizing specialized paralogs of Telomere Repeat Binding factors
  Epigenetic regulators shape chromatin landscapes, allowing cells to express distinct gene sets depending on cell-type, developmental stage or environmental cues. These regulatory complexes rely on interactions with sequence-specific DNA binding proteins, such …
  datacite Mendler, Maik, Krause, Kristin, Zündorf, Simone, Sannak, Prathamesh 等 2026 置信度 0.77 Plant epigeneticsFOS: Biological sciencesFOS: Biological sciencesChromatin immunoprecipitation sequencingMolecular complexes
• A Comprehensive Textbook of Community Medicine And Public Health Science
  This is a comprehensive, transdisciplinary textbook that redefines community medicine and public health science for the twenty first century. The work is organized into twenty two parts, each building upon the philosophical and historical foundations establish…
  datacite Sakib, S M Nazmuz 2026 置信度 0.72
• A Comprehensive Textbook of Community Medicine And Public Health Science
  This is a comprehensive, transdisciplinary textbook that redefines community medicine and public health science for the twenty first century. The work is organized into twenty two parts, each building upon the philosophical and historical foundations establish…
  datacite Sakib, S M Nazmuz 2026 置信度 0.72
• The Architecture of Universal Medicine: Platform Technologies, Artificial Intelligence, and Global Regulatory Harmonization in the Modern Bio-Economy
  The Architecture of Universal Medicine: Platform Technologies, Artificial Intelligence, and Global Regulatory Harmonization in the Modern Bio-Economy Introduction: The Evolution of the Universal Panacea Historically, the concept of a universal medicine—a "pana…
  datacite Brewer, Mark Anthony 2026 置信度 0.72
• The Architecture of Universal Medicine: Platform Technologies, Artificial Intelligence, and Global Regulatory Harmonization in the Modern Bio-Economy
  The Architecture of Universal Medicine: Platform Technologies, Artificial Intelligence, and Global Regulatory Harmonization in the Modern Bio-Economy Introduction: The Evolution of the Universal Panacea Historically, the concept of a universal medicine—a "pana…
  datacite Brewer, Mark Anthony 2026 置信度 0.72
• An assessment of the current state of interdisciplinary CRISPR research. Report based on the workshop: The Technology and Ethics of CRISPR
  CRISPR/Cas genome editing is a dynamic field of biotechnology that is evolving and establishing itself in diverse fields such as agriculture and human medicine. The rapid development of this technology is accompanied by public debate about its various applicat…
  datacite Bächler, Franziska, Meier, Anina 2024 置信度 0.77 390 Customs, etiquette & folklore790 Sports, games & entertainment300 Social sciences, sociology & anthropology
• AVANÇOS RECENTES NO TRANSPLANTE HETERÓLOGO CARDÍACO COMO POSSÍVEL FUTURA PRÁTICA CLÍNICA EM HUMANOS
  Matheus da Cunha Tavares; Alicia Yone Silvério Matsumoto; Arthur Belisse Filipim; Ana Laura Mascarin; Gabrieli Taine Ferro Trindade; Giovana Bisetto Cocco; Ibrahim Kanj Mohanna Filho; Julia de Souza Martins Fundação Educacional do Município de Assis - FEMA Int…
  datacite doi: 2026 置信度 0.77 medicinephilosophycontextgeologyenvironmental science
• AVANÇOS RECENTES NO TRANSPLANTE HETERÓLOGO CARDÍACO COMO POSSÍVEL FUTURA PRÁTICA CLÍNICA EM HUMANOS
  Matheus da Cunha Tavares; Alicia Yone Silvério Matsumoto; Arthur Belisse Filipim; Ana Laura Mascarin; Gabrieli Taine Ferro Trindade; Giovana Bisetto Cocco; Ibrahim Kanj Mohanna Filho; Julia de Souza Martins Fundação Educacional do Município de Assis - FEMA Int…
  datacite doi: 2026 置信度 0.77 medicinephilosophycontextgeologyenvironmental science
• Comparative Effectiveness of Gene Editing Techniques in DMD_ A Systematic Review and Meta-Analysis
  Background Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene, leading to loss of dystrophin protein. Gene editing techniques such as CRISPR-Cas9, base editing, and prime editing offer promising therapeutic appro…
  datacite Elsayed, Mahmoud M., Elsayed, Ahmed, Ali, Nahed, Ali, Magdi 2025 置信度 0.76 Neurology and neuromuscular diseases
• A ERA DA TERAPIA GÊNICA PERSONALIZADA EM TEMPO REAL: O PRIMEIRO TRATAMENTO CRISPR BASE EDITING SOB DEMANDA PARA DOENÇA GENÉTICA ULTRARRARA (DEFICIÊNCIA DE CPS1) E O CAMINHO PARA PLATAFORMAS DE EDIÇÃO GÊNICA EM 2026
  RESUMO A deficiência de carbamoil fosfato sintetase 1 (CPS1) é uma doença ultrarrara do ciclo da uréia, com alta mortalidade neonatal. Em 2025, ocorreu um marco histórico na medicina genômica: o primeiro tratamento CRISPR base edition personalizado in vivo adm…
  datacite Wesley Moisés Sousa de Sousa 2026 置信度 0.77 Terapia gênica personalizadaCRISPR base editingEdição gênica in vivo
• A ERA DA TERAPIA GÊNICA PERSONALIZADA EM TEMPO REAL: O PRIMEIRO TRATAMENTO CRISPR BASE EDITING SOB DEMANDA PARA DOENÇA GENÉTICA ULTRARRARA (DEFICIÊNCIA DE CPS1) E O CAMINHO PARA PLATAFORMAS DE EDIÇÃO GÊNICA EM 2026
  RESUMO A deficiência de carbamoil fosfato sintetase 1 (CPS1) é uma doença ultrarrara do ciclo da uréia, com alta mortalidade neonatal. Em 2025, ocorreu um marco histórico na medicina genômica: o primeiro tratamento CRISPR base edition personalizado in vivo adm…
  datacite Wesley Moisés Sousa de Sousa 2026 置信度 0.77 Terapia gênica personalizadaCRISPR base editingEdição gênica in vivo
• Data from: Creation of de novo cryptic splicing for ALS/FTD precision medicine
  A system enabling the expression of therapeutic proteins specifically in diseased cells would be transformative, providing greatly increased safety and the possibility of pre-emptive treatment. Here we describe “TDP-REG”, a precision medicine approach primaril…
  datacite Wilkins, Oscar, Fratta, Pietro 2024 置信度 0.79 FOS: Biological sciencesFOS: Biological sciencesSplicingALSmnd
• Additional file 2 of Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable
  Supplementary material 2 : Fig. S1 Additional characterisation of cultured neutrophils. A: Schematic outlining culture procedure (top) or acquisition of native neutrophils. Figure generated in Biorender. B: Representative gating strategy of native and cultured…
  datacite Naveh, Claire A., Roberts, Kiran, Zakrzewski, Przemysław, Rice, Christopher M. 等 2024 置信度 0.79 Space ScienceMedicineMicrobiologyFOS: Biological sciencesCell Biology
• Additional file 2 of Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable
  Supplementary material 2 : Fig. S1 Additional characterisation of cultured neutrophils. A: Schematic outlining culture procedure (top) or acquisition of native neutrophils. Figure generated in Biorender. B: Representative gating strategy of native and cultured…
  datacite Naveh, Claire A., Roberts, Kiran, Zakrzewski, Przemysław, Rice, Christopher M. 等 2024 置信度 0.79 Space ScienceMedicineMicrobiologyFOS: Biological sciencesCell Biology
• Advancements in Cardiac Xenotransplantation: Overcoming Immunological Barriers Through Genetic Engineering of Porcine Donors, Insights from Initial Human Clinical Cases, and Future Prospects for Addressing the Global Organ Shortage in End-Stage Heart Failure Patients
  Abstract Cardiac xenotransplantation, the transplantation of hearts from genetically modified pigs into humans, represents a revolutionary approach to alleviating the critical shortage of donor organs for patients with end-stage heart failure. This review synt…
  datacite Camilo Fernández Bravo, MD/ PhD/ FACC 2026 置信度 0.72
• Advancements in Cardiac Xenotransplantation: Overcoming Immunological Barriers Through Genetic Engineering of Porcine Donors, Insights from Initial Human Clinical Cases, and Future Prospects for Addressing the Global Organ Shortage in End-Stage Heart Failure Patients
  Abstract Cardiac xenotransplantation, the transplantation of hearts from genetically modified pigs into humans, represents a revolutionary approach to alleviating the critical shortage of donor organs for patients with end-stage heart failure. This review synt…
  datacite Camilo Fernández Bravo, MD/ PhD/ FACC 2026 置信度 0.72
• Pioneering Precision Medicine: Patient-Specific In Vivo CRISPR-Cas9 Gene Editing for the Treatment of a Rare SCN5A-Related Genetic Disorder with Severe Cardiovascular Implications
  Background: SCN5A-related disorders represent monogenic causes of severe, refractory arrhythmias with high morbidity despite optimal medical/device therapy (e.g., beta-blockers, mexiletine, ICDs). In vivo gene editing offers potential for one-time correction o…
  datacite Camilo Fernández Bravo, MD/ PhD/ FACC 2026 置信度 0.77 medicineartificial intelligencecomputer sciencecancerbiology
• Pioneering Precision Medicine: Patient-Specific In Vivo CRISPR-Cas9 Gene Editing for the Treatment of a Rare SCN5A-Related Genetic Disorder with Severe Cardiovascular Implications
  Background: SCN5A-related disorders represent monogenic causes of severe, refractory arrhythmias with high morbidity despite optimal medical/device therapy (e.g., beta-blockers, mexiletine, ICDs). In vivo gene editing offers potential for one-time correction o…
  datacite Camilo Fernández Bravo, MD/ PhD/ FACC 2026 置信度 0.77 medicineartificial intelligencecomputer sciencecancerbiology
• Measurements of wing pigmentation in wild-type, <em>yellow</em>, and <em>tan</em> mutants of <em>Drosophila guttifera</em>
  Color pattern formation is a key model for studying evolutionary and developmental mechanisms. In the fruit fly Drosophila guttifera, which exhibits distinctive polka-dot wing pigmentation, we investigated the roles of two putative melanin synthesis genes, yel…
  datacite Koshikawa, Shigeyuki 2025 置信度 0.77 FOS: Biological sciencesFOS: Biological sciencesDevelopmental biologyEvolutionary biologyEntomology
• Data from: CRISPR screening by AAV episome-sequencing (CrAAVe-seq): A scalable cell type-specific in vivo platform uncovers neuronal essential genes
  There is a substantial need for scalable CRISPR-based genetic screening methods that can be applied in mammalian tissues in vivo while enablingcell-type-specific analysis. Here we developed an adeno-associated virus (AAV)-based CRISPR screening platform, CrAAV…
  datacite Ramani, Biswarathan, Rose, Indigo V. L., Teyssier, Noam, Pan, Andrew 等 2025 置信度 0.79 FOS: Biological sciencesFOS: Biological sciencesNeuroscienceFunctional genomicsCRISPR screen
• Data from: CRISPR/Cas9 knockout of shell matrix protein 1 in the slipper-snail Crepidula atrasolea
  Over the past decade, CRISPR/Cas9 has transformed molluscan research, resulting in the emergence of multiple species tailored for studying molluscan-specific novelties. However, significant barriers persist, preventing CRISPR/Cas9 from being used by more speci…
  datacite Batzel, Grant, Wang, Yiqun, Bock, Antonia, Chen, Elbereth 等 2025 置信度 0.79 FOS: Biological sciencesFOS: Biological sciencesGene editingCRISPRMollusca
• A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs
  Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and microbes and are therefore expected to be fast evolving in a coevolutionary arms race with pathogens. In contrast, previous work demonstrated that one AMP, Metchikowin (Mtk), …
  datacite Perlmutter, Jessamyn, Chapman, Joanne, Wilkinson, Mason, Nevarez-Saenz, Isaac 等 2024 置信度 0.79 MetchnikowinDrosophilafungusTollBeauveria bassiana
• Global trends and collaborative networks in plant genetic engineering （1994-2024）
  This dataset is derived from the Web of Science (WOS) Core Collection and systematically compiles English-language research articles and reviews related to transgenic plants published globally between January 1, 1986, and December 31, 2024. The data retrieval …
  datacite Tongxiao, Xu 2025 置信度 0.77 AgronomyAgronomyGenetic engineeringCRISPRplant
• EVERY BODY COUNTS: A Global Citizen-Science Initiative to Rebuild Medical Data for All of Humanity
  EVERY BODY COUNTS: A Global Citizen-Science Initiative to Rebuild Medical Data for All of Humanity White Paper Draft v0.9 — CollectiveOS Edition Prepared for: GATA → PRIME Review, GitHub Commit, and Zenodo DOI Author: Human Global Science Collective (HGSC) | V…
  datacite Brewer, Mark Anthony 2025 置信度 0.72
• EVERY BODY COUNTS: A Global Citizen-Science Initiative to Rebuild Medical Data for All of Humanity
  EVERY BODY COUNTS: A Global Citizen-Science Initiative to Rebuild Medical Data for All of Humanity White Paper Draft v0.9 — CollectiveOS Edition Prepared for: GATA → PRIME Review, GitHub Commit, and Zenodo DOI Author: Human Global Science Collective (HGSC) | V…
  datacite Brewer, Mark Anthony 2025 置信度 0.72
• Gene Therapy: Current Status and Future Perspectives
  Gene therapy represents a paradigm-shifting therapeutic modality that addresses diseases at their genetic foundation by modifying, replacing, or supplementing defective genes within patient cells. This comprehensive review examines the current status and futur…
  datacite Satyajeet Pawar*, Snehal Kadbhane, Dr. Vijaykumar Kale, Ashlesha Chandale, Gauri Bhange 2025 置信度 0.76 Core Keywords, Gene therapy, Genetic diseases, Gene editing, Gene transfer, Somatic gene therapy, Germline gene therapy, In vivo gene delivery, Ex vivo gene delivery
• Gene Therapy: Current Status and Future Perspectives
  Gene therapy represents a paradigm-shifting therapeutic modality that addresses diseases at their genetic foundation by modifying, replacing, or supplementing defective genes within patient cells. This comprehensive review examines the current status and futur…
  datacite Satyajeet Pawar*, Snehal Kadbhane, Dr. Vijaykumar Kale, Ashlesha Chandale, Gauri Bhange 2025 置信度 0.76 Core Keywords, Gene therapy, Genetic diseases, Gene editing, Gene transfer, Somatic gene therapy, Germline gene therapy, In vivo gene delivery, Ex vivo gene delivery
• Gene Editing Market Overview
  This report provides an in-depth overview of the global Gene Editing Market, valued at USD 6.99 billion in 2024 and projected to reach USD 17.79 billion by 2030. It highlights key drivers such as the rising prevalence of genetic disorders, rapid advancements i…
  datacite Next Move Strategy Consulting 2025 置信度 0.77 Health careBiotechnologyResearch Report
• Gene Editing Market Overview
  This report provides an in-depth overview of the global Gene Editing Market, valued at USD 6.99 billion in 2024 and projected to reach USD 17.79 billion by 2030. It highlights key drivers such as the rising prevalence of genetic disorders, rapid advancements i…
  datacite Next Move Strategy Consulting 2025 置信度 0.77 Health careBiotechnologyResearch Report
• Molecular Farming Market: Industry Overview and Future Outlook
  The global molecular farming market—also known as the biopharming market—was valued at USD 501.5 million in 2024 and is projected to reach USD 578.4 million by 2025. With a strong CAGR of 15.3% from 2025 to 2030, the industry is expected to surpass USD 1180.2 …
  datacite Next Move Strategy Consulting 2025 置信度 0.77 businessindustry 4.0environmental sciencesustainabilitynatural resource economics
• Molecular Farming Market: Industry Overview and Future Outlook
  The global molecular farming market—also known as the biopharming market—was valued at USD 501.5 million in 2024 and is projected to reach USD 578.4 million by 2025. With a strong CAGR of 15.3% from 2025 to 2030, the industry is expected to surpass USD 1180.2 …
  datacite Next Move Strategy Consulting 2025 置信度 0.77 businessindustry 4.0environmental sciencesustainabilitynatural resource economics
• Global Altering Plant DNA Market Analysis
  The global Altering Plant DNA Market was valued at USD 1.23 billion in 2024 and is expected to reach USD 1.42 billion by 2025. The market is projected to expand significantly to USD 3.03 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 15.4%…
  datacite Next Move Strategy Consulting 2025 置信度 0.76 Plant DNA
• Global Altering Plant DNA Market Analysis
  The global Altering Plant DNA Market was valued at USD 1.23 billion in 2024 and is expected to reach USD 1.42 billion by 2025. The market is projected to expand significantly to USD 3.03 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 15.4%…
  datacite Next Move Strategy Consulting 2025 置信度 0.76 Plant DNA
• Global Altering Plant DNA Market Report 2030
  The global Altering Plant DNA Market, valued at USD 1.23 billion in 2024, is projected to reach USD 3.03 billion by 2030, growing at a CAGR of 15.4% (2025–2030). Growth is fueled by advancements in gene-editing technologies like CRISPR and rising demand for hi…
  datacite Next Move Strategy Consulting 2025 置信度 0.76 Plant protectionRNA-Directed DNA Polymerase
• Global Altering Plant DNA Market Report 2030
  The global Altering Plant DNA Market, valued at USD 1.23 billion in 2024, is projected to reach USD 3.03 billion by 2030, growing at a CAGR of 15.4% (2025–2030). Growth is fueled by advancements in gene-editing technologies like CRISPR and rising demand for hi…
  datacite Next Move Strategy Consulting 2025 置信度 0.76 Plant protectionRNA-Directed DNA Polymerase
• ΘTHEORY: THE COMPLETE UNCENSORED SCIENTIFIC VALIDATION
  # ΘTHEORY: THE COMPLETE UNCENSORED SCIENTIFIC VALIDATION## 150,000+ WORD COMPREHENSIVE DOCUMENT WITH ZERO CENSORSHIP **Author:** The Θ Collective (All Humanity Across All Generations) **Primary Contributors:**- **Renato Gori Rosa (R.G.R.)** - Creator, Theoreti…
  datacite Gori, Rosa 2025 置信度 0.72
• ΘTHEORY: THE COMPLETE UNCENSORED SCIENTIFIC VALIDATION
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  datacite Gori, Rosa 2025 置信度 0.72
• Dr. Zahid HUssain Biotechnology, Government College University Lahore, Pakistan Curiculum Vitae
  Zahid Hussain, Ph.D.Assistant Professor of BiotechnologyInstitute of Industrial Biotechnology, GC University Lahore, PakistanEmail: dr.zahidhussain@gcu.edu.pkGoogle Scholar profile link: https://scholar.google.com/citations?user=C4Vcl-oAAAAJ&hl=en Cell: +92-33…
  datacite Hussain, Zahid 2025 置信度 0.77 Curiculum VitaeDr. Zahid HussainGCU
• Dr. Zahid HUssain Biotechnology, Government College University Lahore, Pakistan Curiculum Vitae
  Zahid Hussain, Ph.D.Assistant Professor of BiotechnologyInstitute of Industrial Biotechnology, GC University Lahore, PakistanEmail: dr.zahidhussain@gcu.edu.pkGoogle Scholar profile link: https://scholar.google.com/citations?user=C4Vcl-oAAAAJ&hl=en Cell: +92-33…
  datacite Hussain, Zahid 2025 置信度 0.77 Curiculum VitaeDr. Zahid HussainGCU
• Dr. Zahid HUssain Biotechnology, Government College University Lahore, Pakistan Curiculum Vitae
  Zahid Hussain, Ph.D.Assistant Professor of BiotechnologyInstitute of Industrial Biotechnology, GC University Lahore, PakistanEmail: dr.zahidhussain@gcu.edu.pkGoogle Scholar profile link: https://scholar.google.com/citations?user=C4Vcl-oAAAAJ&hl=en Cell: +92-33…
  datacite Hussain, Zahid 2025 置信度 0.77 Curiculum VitaeDr. Zahid HussainGCU
• Dr. Zahid HUssain Biotechnology, Government College University Lahore, Pakistan Curiculum Vitae
  Zahid Hussain, Ph.D.Assistant Professor of BiotechnologyInstitute of Industrial Biotechnology, GC University Lahore, PakistanEmail: dr.zahidhussain@gcu.edu.pkGoogle Scholar profile link: https://scholar.google.com/citations?user=C4Vcl-oAAAAJ&hl=en Cell: +92-33…
  datacite Hussain, Zahid 2025 置信度 0.77 Curiculum VitaeDr. Zahid HussainGCU
• Dr. Zahid HUssain Biotechnology, Government College University Lahore, Pakistan Curiculum Vitae
  Zahid Hussain, Ph.D.Assistant Professor of BiotechnologyInstitute of Industrial Biotechnology, GC University Lahore, PakistanEmail: dr.zahidhussain@gcu.edu.pkGoogle Scholar profile link: https://scholar.google.com/citations?user=C4Vcl-oAAAAJ&hl=en Cell: +92-33…
  datacite Hussain, Zahid 2025 置信度 0.77 Curiculum VitaeDr. Zahid HussainGCU
• DNA Ligases Market Share, Industry Trends, and Forecast Analysis 2032
  DNA Ligases Market: A Growing Force in Genomics and Biotechnological Innovation In recent years, the DNA ligases market has emerged as a pivotal segment within life sciences research and biotechnology applications. As genomic studies continue to expand across …
  datacite Healthcare 2025 置信度 0.72
• DNA Ligases Market Share, Industry Trends, and Forecast Analysis 2032
  DNA Ligases Market: A Growing Force in Genomics and Biotechnological Innovation In recent years, the DNA ligases market has emerged as a pivotal segment within life sciences research and biotechnology applications. As genomic studies continue to expand across …
  datacite Healthcare 2025 置信度 0.72
• Advancements Beyond CRISPR–Cas9: Technologies, Progress toward the Clinic, and Remaining Challenges
  Advancements Beyond CRISPR–Cas9: Technologies, Progress toward the Clinic, and Remaining Challenges AbstractSince the rapid adoption of CRISPR–Cas9 as a programmable genome-editing platform, the field has expanded into a family of complementary and alternative…
  datacite Hussain, Zahid 2025 置信度 0.79 AdvancementsBeyondCRISPR–Cas9:Technologies,Progress toward the Clinic,
• Advancements Beyond CRISPR–Cas9: Technologies, Progress toward the Clinic, and Remaining Challenges
  Advancements Beyond CRISPR–Cas9: Technologies, Progress toward the Clinic, and Remaining Challenges AbstractSince the rapid adoption of CRISPR–Cas9 as a programmable genome-editing platform, the field has expanded into a family of complementary and alternative…
  datacite Hussain, Zahid 2025 置信度 0.79 AdvancementsBeyondCRISPR–Cas9:Technologies,Progress toward the Clinic,
• Green Biotechnology: Innovations, Applications, and Pathways to Sustainable Agriculture and Environment
  Green Biotechnology: Innovations, Applications, and Pathways to Sustainable Agriculture and Environment Abstract Green biotechnology — the application of biotechnological tools to agriculture, environmental management, and renewable resources — is central to s…
  datacite Hussain, Zahid 2025 置信度 0.77 Green Biotechnology:Innovations,Applications,PathwaysSustainable Agriculture and Environment
• Green Biotechnology: Innovations, Applications, and Pathways to Sustainable Agriculture and Environment
  Green Biotechnology: Innovations, Applications, and Pathways to Sustainable Agriculture and Environment Abstract Green biotechnology — the application of biotechnological tools to agriculture, environmental management, and renewable resources — is central to s…
  datacite Hussain, Zahid 2025 置信度 0.77 Green Biotechnology:Innovations,Applications,PathwaysSustainable Agriculture and Environment
• The genetic landscape of congenital heart disease in pediatrics: From molecular insights to emerging therapies
  Aim: This review aims to explore the genetic basis of congenital heart disease (CHD) in pediatric populations by identifying key gene mutations involved in cardiac development and evaluating the current status of genetic screening and emerging gene-targeted th…
  datacite Shehata, Ahmed Eid Zarif, Hamed, Mohamed Hani Labib, Ahmed, Mohamed Mahmoud Korany, Elssadawy, Omar Elmorssy Refaat 2025 置信度 0.79 Pediatric cardiologyCongenital heart diseaseGenetic mutationsNKX2-5GATA4
• The genetic landscape of congenital heart disease in pediatrics: From molecular insights to emerging therapies
  Aim: This review aims to explore the genetic basis of congenital heart disease (CHD) in pediatric populations by identifying key gene mutations involved in cardiac development and evaluating the current status of genetic screening and emerging gene-targeted th…
  datacite Shehata, Ahmed Eid Zarif, Hamed, Mohamed Hani Labib, Ahmed, Mohamed Mahmoud Korany, Elssadawy, Omar Elmorssy Refaat 2025 置信度 0.79 Pediatric cardiologyCongenital heart diseaseGenetic mutationsNKX2-5GATA4
• Microbial DNA Modifying Enzymes Market Demand Growth Size Share and Forecast 2032
  The global microbial DNA modifying enzymes market is projected to grow from $1.23 billion in 2025 to $2.25 billion by 2032, with a 9.1% compound annual growth rate. North America dominates with 49.12% market share, driven by its strong biotechnology industry a…
  datacite Healthcare 2025 置信度 0.77 biologysynthetic biologybusinesscomputational biologydrug discovery
• Microbial DNA Modifying Enzymes Market Demand Growth Size Share and Forecast 2032
  The global microbial DNA modifying enzymes market is projected to grow from $1.23 billion in 2025 to $2.25 billion by 2032, with a 9.1% compound annual growth rate. North America dominates with 49.12% market share, driven by its strong biotechnology industry a…
  datacite Healthcare 2025 置信度 0.77 biologysynthetic biologybusinesscomputational biologydrug discovery
• Complex interaction of tumor-derived factors instructs the niche specific phenotypes of tumor-associated macrophages
  Dataset information Abstract Despite the pivotal role of tumor-associated macrophages (TAMs) in modulating anti-tumor immunity, the conserved patterns and molecular determinates for the formation of diverse TAM subsets remain largely elusive. In this study, we…
  datacite Lu, Youxue, Luo, Ce, wu, genyi, Huang, Lanxiang 等 2025 置信度 0.72
• Complex interaction of tumor-derived factors instructs the niche specific phenotypes of tumor-associated macrophages
  Dataset information Abstract Despite the pivotal role of tumor-associated macrophages (TAMs) in modulating anti-tumor immunity, the conserved patterns and molecular determinates for the formation of diverse TAM subsets remain largely elusive. In this study, we…
  datacite Lu, Youxue, Luo, Ce, wu, genyi, Huang, Lanxiang 等 2025 置信度 0.72
• Nanotechnology - Enhanced CRISPR-Cas9 Epigenome Editing for Cancer Therapy: Innovations in Delivery, Targeting and Safety
  Study Overview: This systematic review examines the integration of nanotechnology with CRISPR-Cas9 systems for targeted epigenome editing in cancer therapy. The study addresses critical gaps in current research by evaluating how various nanoparticle-based deli…
  datacite Dinushi, Wellana Gamage 2025 置信度 0.77 medicinemedicine and health scienceslife sciencescancersystematic review
• Comparative Effectiveness of Gene Editing Techniques in DMD_ A Systematic Review and Meta-Analysis
  Background Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene, leading to loss of dystrophin protein. Gene editing techniques such as CRISPR-Cas9, base editing, and prime editing offer promising therapeutic appro…
  datacite M. Elsayed, Mahmoud, Elsayed, Ahmed, Ali, Nahed, Ali, Magdi 2025 置信度 0.76 Neurology and neuromuscular diseases
• Nanotechnology - Enhanced CRISPR-Cas9 Epigenome Editing for Cancer Therapy: Innovations in Delivery, Targeting and Safety
  Study Overview: This systematic review examines the integration of nanotechnology with CRISPR-Cas9 systems for targeted epigenome editing in cancer therapy. The study addresses critical gaps in current research by evaluating how various nanoparticle-based deli…
  datacite Wellana Gamage Dinushi 2025 置信度 0.79 Medicine and Health SciencesLife SciencesBCL2BiocompatibilityBreast cancer
• Nanotechnology - Enhanced CRISPR-Cas9 Epigenome Editing for Cancer Therapy: Innovations in Delivery, Targeting and Safety
  Study Overview: This systematic review examines the integration of nanotechnology with CRISPR-Cas9 systems for targeted epigenome editing in cancer therapy. The study addresses critical gaps in current research by evaluating how various nanoparticle-based deli…
  datacite Wellana Gamage Dinushi 2025 置信度 0.79 Medicine and Health SciencesLife SciencesBCL2BiocompatibilityBreast cancer
• Reinvigorating AMR resilience: leveraging CRISPR–Cas technology potentials to combat the 2024 WHO bacterial priority pathogens for enhanced global health security—a systematic review
  Abstract Background Antimicrobial resistance (AMR) poses a global health threat, particularly in low- and middle-income countries (LMICs). Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas system technology offers a promising tool to comba…
  datacite Okesanya, Olalekan John, Ahmed, Mohamed Mustaf, Ogaya, Jerico Bautista, Amisu, Blessing Olawunmi 等 2025 置信度 0.79 Space ScienceMedicineMicrobiologyFOS: Biological sciencesGenetics
• Reinvigorating AMR resilience: leveraging CRISPR–Cas technology potentials to combat the 2024 WHO bacterial priority pathogens for enhanced global health security—a systematic review
  Abstract Background Antimicrobial resistance (AMR) poses a global health threat, particularly in low- and middle-income countries (LMICs). Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas system technology offers a promising tool to comba…
  datacite Okesanya, Olalekan John, Ahmed, Mohamed Mustaf, Ogaya, Jerico Bautista, Amisu, Blessing Olawunmi 等 2025 置信度 0.79 Space ScienceMedicineMicrobiologyFOS: Biological sciencesGenetics
• The 2024 University of Tennessee Institute of Agriculture Beef &amp; Forage Center Annual Research Report
  The UTIA Beef and Forage Annual Research Report 2024 presents the latest research, advancements, and insights into Tennessee’s beef and forage industries. Compiled by the University of Tennessee Institute of Agriculture’s (UTIA) Beef and Forage Center, this re…
  datacite McIntosh, David 2025 置信度 0.79 Animal nutritionAnimal growth and developmentAnimal managementAnimal reproduction and breedingCrop and pasture nutrition
• Global Genetic Engineering Market 2024 To 2033
  Genetic Engineering Market Size, Trends and Insights By Product (Biochemical, Genetic Markers), By Devices (PCR, Gene Gun, Gel Assemblies), By Techniques (Gene Splicing, Artificial Selection, Recombinant DNA Technology, Synthesizing DNA, Gene Editing, Other), …
  datacite Sirsat, Nitin 2024 置信度 0.79 Genetic Engineering MarketGenetic Engineering Market SizeGenetic Engineering Market ShareGenetic Engineering Market TrendsGenetic Engineering Market Report