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cancer research

GeneTech 知识引擎共收录 74 篇相关科研实体，横跨 14 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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代表性文献（按质量分排序，前 60 条）

• Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology
  2026 · 合成生物与生物制造 · Terminally exhausted CD8 + T cells (Ttex) are emerging as clinically relevant immune subsets across solid tumors, marked by sustained inhibitory receptor expression, loss of TCF1, and limited proliferative capacity. Once…
• ChatExosome: An Artificial Intelligence (AI) Agent Based on Deep Learning of Exosomes Spectroscopy for Hepatocellular Carcinoma (HCC) Diagnosis
  2025 · AI Agent 生态 · Large language models (LLMs) hold significant promise in the field of medical diagnosis. There are still many challenges in the direct diagnosis of hepatocellular carcinoma (HCC). α-Fetoprotein (AFP) is a commonly used t…
• Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors
  2025 · 脑科学 · Recent global data show that cancers of the digestive system are responsible for approximately one-third of all cancer-related deaths worldwide, underscoring the urgent need for innovative therapeutic strategies. In this…
• Bone marrow microenvironment in myelodysplastic neoplasms: insights into pathogenesis, biomarkers, and therapeutic targets
  2025 · 碳中和与 CCUS · Myelodysplastic neoplasms (MDS) represent a heterogeneous group of malignant hematopoietic stem and progenitor cell (HSPC) disorders characterized by cytopenia, ineffective hematopoiesis, as well as the potential to prog…
• PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma
  2025 · 碳中和与 CCUS · The incidence of papillary thyroid carcinoma (PTC) has been rising annually, with papillary thyroid microcarcinoma (PTMC) accounting for more than half of the cases. While most PTMCs exhibit indolent growth and a favorab…
• The role of quantum dots in enhancing the therapeutic targeting of cancer stem cells
  2025 · 量子材料 · In recent years, cancer stem cells have emerged as an interesting field in oncology due to their metastatic and resistance potential to chemotherapy and radiation therapy, thus resulting in the resurfacing of cancer even…
• NF-κB in biology and targeted therapy: new insights and translational implications
  2024 · 生物计算 · NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researcher…
• Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells
  2024 · 生物计算 · Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the an…
• Cancer Cell Targeting Via Selective Transferrin Receptor Labeling Using Protein-Derived Carbon Dots
  2024 · 碳中和与 CCUS · Carbon dot (CD) nanoparticles offer tremendous advantages as fluorescent probes in bioimaging and biosensing; however, they lack specific affinity for biomolecules, limiting their practical applications in selective targ…
• Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
  2024 · 碳中和与 CCUS · Hepatocellular carcinoma (HCC) is characterized by high incidence and fatality rates worldwide. In our exploration of prognostic factors in HCC, the 26s proteasome subunit, non-ATPase 1 (PSMD1) protein emerged as a signi…
• Immune Checkpoint Inhibitor Combined with Antiangiogenic Agent Synergistically Improving the Treatment Efficacy for Solid Tumors
  2024 · 碳中和与 CCUS · In recent years, the combination of immune checkpoint inhibitors (ICIs) with antiangiogenic agents has led to significant breakthroughs in cancer treatment. Such as programmed cell death 1 (PD-1), programmed cell death l…
• Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution
  2024 · 碳中和与 CCUS · BACKGROUND: Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role…
• Histidine phosphatase-ferroptosis crosstalk modulation for efficient hepatocellular carcinoma treatment
  2024 · 碳中和与 CCUS · Altering the mechanisms of tumor cell death and overcoming the limitations of traditional chemotherapy is pivotal to contemporary tumor treatment. Inducing ferroptosis, while circumventing safety concerns associated with…
• CircXRN2 accelerates colorectal cancer progression through regulating miR-149-5p/MACC1 axis and EMT
  2024 · 碳中和与 CCUS · In China, there has been a persistent upward trend in the incidence and mortality rates of colorectal cancer (CRC), with CRC ranking second in incidence and fifth in mortality among all malignant tumors. Although circula…
• Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma
  2024 · 碳中和与 CCUS · Head and neck squamous cell carcinoma (HNSCC) is a significant healthcare burden globally. Previous research using single-cell transcriptome analysis identified TGFBI as a crucial marker for the partial-epithelial-mesenc…
• Primary Resistance to RET Inhibition in a RET Fusion-Positive Pancreatic Neuroendocrine Carcinoma
  2024 · 核能 · We present a 54-year-old White male with a diagnosis of stage IV pancreatic neuroendocrine carcinoma. Next-generation sequencing of the tumor/blood identified a complex tumor genome, which included a rearranged during tr…
• Targeting fusion oncoproteins in childhood cancers: challenges and future opportunities for developing therapeutics
  2024 · 核能 · Fusion oncoproteins are associated with childhood cancers and have proven challenging to target, aside from those that include kinases. As part of its efforts for targeting childhood cancers, the National Cancer Institut…
• Ultrasound-assisted encapsulating folic acid-based carbon quantum dots within breast cancer cell-derived exosomes as a co-receptors-mediated anticancer nanocarrier for enhanced breast cancer therapy
  2024 · 量子材料 · The nonspecific nature of cancer drug delivery often results in substantial toxic side effects during treatments for breast cancer. To mitigate these negative outcomes, our approach involves loading methotrexate (MTX) wi…
• Immunomodulatory R848-Loaded Anti-PD-L1-Conjugated Reduced Graphene Oxide Quantum Dots for Photothermal Immunotherapy of Glioblastoma
  2024 · 量子材料 · Glioblastoma multiforme (GBM) is the most severe form of brain cancer and presents unique challenges to developing novel treatments due to its immunosuppressive milieu where receptors like programmed death ligand 1 (PD-L…
• Proteogenomic insights into the biology and treatment of pan-melanoma
  2024 · 合成生物与生物制造 · Melanoma is one of the most prevalent skin cancers, with high metastatic rates and poor prognosis. Understanding its molecular pathogenesis is crucial for improving its diagnosis and treatment. Integrated analysis of mul…
• Tumor microenvironment signaling and therapeutics in cancer progression
  2023 · 合成生物与生物制造 · Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. …
• Role of Artificial Intelligence in Cancer Research Education
  2026 · 医疗人工智能 · Cancer remains a leading cause of mortality worldwide, driving urgent demand for advanced research and education frameworks capable of keeping pace with rapidly evolving scientific knowledge. Traditional cancer research …
• Role of Artificial Intelligence in Cancer Research Education
  2026 · 医疗人工智能 · Cancer remains a leading cause of mortality worldwide, driving urgent demand for advanced research and education frameworks capable of keeping pace with rapidly evolving scientific knowledge. Traditional cancer research …
• Complex Karyotype and TP53 Alterations in AML and MDS
  2026 · 碳中和与 CCUS · Background/Objectives: A complex karyotype (CK) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs) is defined as the presence of three or more unrelated chromosomal abnormalities in the absence of defin…
• Notch1 and Major Vault Proteins Modulate Temozolomide Resistance in Glioblastoma
  2025 · 碳中和与 CCUS · The development of resistance to chemotherapy in the case of aggressive glioblastoma multiforme (GBM) presents a significant treatment challenge. Dysregulation of the Notch signalling pathway promotes tumour proliferatio…
• Digital Twin-Based Multiscale Models for Biomarker Discovery in Kinase and Phosphatase Tumorigenic Processes
  2025 · 数字孪生 · Digital twin is a mathematical model that virtually represents a physical object or process and predicts its behavior at future time points. These simulation models enable a deeper understanding of tumorigenic processes …
• Quantum biological convergence: quantum computing accelerates KRAS inhibitor design
  2025 · 生物计算 · In a recent study published in Nature Biotechnology , Mohammad Ghazi Vakili et al. applied quantum computing and generative machine learning—specifically Quantum Circuit Born Machines (QCBMs) and Long Short-Term Memory (…
• To go or not to go? Biological logic gating engineered T cells
  2022 · 生物计算 · Genetically engineered T cells have been successfully used in the treatment of hematological malignancies, greatly increasing both progression-free and overall survival in patients. However, the outcomes of patients trea…
• Alternative splicing and cancer: a systematic review
  2021 · 深海科技 · The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors, which would produce multiple different isoforms and diversify protein expression. The aim of the present…
• Osimertinib in Resected EGFR -Mutated Non–Small-Cell Lung Cancer
  2020 · 生物计算 · BACKGROUND: ) mutation-positive advanced non-small-cell lung cancer (NSCLC). The efficacy and safety of osimertinib as adjuvant therapy are unknown. METHODS: mutation-positive NSCLC in a 1:1 ratio to receive either osime…
• Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing
  2020 · 碳中和与 CCUS · Resistance to the chemotherapeutic drug cisplatin has been documented in various types of cancer, while the increased expression of β‑catenin has been observed in cisplatin‑resistant ovarian cancer. However, the involvem…
• Anticancer activities of TCM and their active components against tumor metastasis
  2020 · 中医药工具 · Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, slight side effects and good therapeutic effects. Good anti-tumor effects are shown by Traditional Chinese Medicine prescription, Chinese pa…
• Ultraviolet Radiation Biological and Medical Implications
  2024 · 生物计算 · Ultraviolet (UV) radiation plays a crucial role in the development of melanoma and non-melanoma skin cancers. The types of UV radiation are differentiated by wavelength: UVA (315 to 400 nm), UVB (280 to 320 nm), and UVC …
• Generation and banking of patient-derived glioblastoma organoid and its application in cancer neuroscience
  2024 · 脑科学 · Glioblastoma (GBM) is the most common and deadly tumor in the central nervous system. Although much has been done to optimize treatment options for GBM, the clinical prognosis is still very poor. The recent development o…
• Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation
  2019 · 合成生物与生物制造 · Exosomes hold great potential to deliver therapeutic reagents for cancer treatment due to its inherent low antigenicity. However, several technical barriers, such as low productivity and ineffective cancer targeting, nee…
• Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment
  2019 · 中医药工具 · Therapeutic antibodies targeting PD-1 have made major breakthroughs in cancer treatment. However, the majority of colorectal cancer (CRC) cases are microsatellite stable (MSS) and do not respond to anti-PD-1-based immuno…
• Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
  2018 · 生物计算 · Hyperthermia, the mild elevation of temperature to 40-43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treat…
• Long non‑coding RNA Fer‑1‑like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in�vitro and in�vivo
  2018 · 碳中和与 CCUS · The aim of the present study was to investigate the potential role of long non‑coding RNA Fer‑1‑like family member 4 (FER1L4) in the proliferation of hepatocellular carcinoma (HCC) through the regulation of phosphatase a…
• Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition
  2017 · AI Agent 生态 · Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects which hamper its clinical use. Here, we…
• Epstein-Barr virus BRLF1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells
  2017 · 基因技术工具 · // Sheng-Yen Huang 1 , Chung-Chun Wu 1 , Yu-Jhen Cheng 1 , Sheng-Ping Chou 1 , Yun-Jin Jiang 2 , Kuo-Chang Chu 2 , Ching-Hwa Tsai 3 , Su-Fang Lin 1 and Jen-Yang Chen 1, 3 1 National Institute of Cancer Research, National…
• Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
  2017 · 生命科学 · Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we…
• Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
  2017 · 生命科学 · We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequen…
• Genomic Classification of Cutaneous Melanoma
  2015 · 生命科学 · We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic clas…
• Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment
  2015 · 中医药工具 · Traditional Chinese medicine (TCM) is an important complementary strategy for treating cancer in China. The mechanism is related to regulating the internal environment and remodeling the tumor immunosuppressive microenvi…
• Comprehensive molecular characterization of gastric adenocarcinoma
  2014 · 生物计算 · Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecul…
• Integrated Genomic Characterization of Papillary Thyroid Carcinoma
  2014 · 生命科学 · Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and exte…
• Comprehensive genomic characterization of squamous cell lung cancers
  2012 · 生命科学 · Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no…
• Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
  2008 · 基因技术工具 · Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34+ BM precursor cells using gammaretroviral vectors. While 9 of 10 p…
• Dissection of mechanisms of Chinese medicinal formula Realgar- <i>Indigo naturalis</i> as an effective treatment for promyelocytic leukemia
  2008 · 中医药工具 · To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional Chinese medicine (TCM) prescribe a combination of plant species/minerals, called formulae, based on clinical experience. Nearly 100…
• Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
  1998 · 基因技术工具 · Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. M…
• Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors
  2018 · AI Agent 生态 · INTRODUCTION: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2.1.1), CA IX and XII, involved in complex processes connected to tumorigenesis (pH regulation, metabolism, invasion, and dissemination of the tu…
• The interaction of anticancer therapies with tumor-associated macrophages
  2015 · AI Agent 生态 · Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including …
• Comprehensive genomic characterization of head and neck squamous cell carcinomas
  2015 · 生命科学 · The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are domi…
• Integrated genomic characterization of endometrial carcinoma
  2013 · 生命科学 · We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid t…
• Tumorigenesis and anti-tumor immune responses in Xenopus
  2009 · 碳中和与 CCUS · Despite intense study, the role of the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia remains elusive. We present here a comparative view of the complex interactions…
• Molecular Biology of the Androgen Receptor
  2002 · 生命科学 · Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules. AR primarily is responsible for mediating the physiologic effects of androgens by binding to specific DNA sequences that influence t…
• Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
  2001 · 生物计算 · Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors…
• Molecular Biology of Neuroblastoma
  1999 · 生命科学 · UNLABELLED: PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the c…
• Correlations between cytologic composition and biologic behavior in the glioblastoma multiforme. A postmortem study of 50 cases
  1983 · 生物计算 · The brains of 50 adults with supratentorial glioblastoma multiforme were studied post mortem. The cytologic compositions of the neoplasms were examined in each of three sites: (1) in and around the original tumor bed; (2…
• Integrated genomic characterization of oesophageal carcinoma
  2017 · 生命科学 · Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oes…

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