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crispr

GeneTech 知识引擎共收录 94 篇相关科研实体，横跨 13 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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代表性文献（按质量分排序，前 60 条）

• Data and code for LUCas: Light-Uncaged Cas13a using photocleavable interfering guide RNAs
  2026 · 生物计算 · CRISPR diagnostics enable sensitive detection of infectious diseases, with the RNA endonuclease Cas13a providing sequence-specific RNA detection through target-activated collateral cleavage of fluorescent reporters. Back…
• Data from: CRISPR/Cas9 knockout of shell matrix protein 1 in the slipper-snail Crepidula atrasolea
  2025 · 基因技术工具 · Over the past decade, CRISPR/Cas9 has transformed molluscan research, resulting in the emergence of multiple species tailored for studying molluscan-specific novelties. However, significant barriers persist, preventing C…
• CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d
  2025 · 基因技术工具 · Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage…
• A synthetic genomics-based African swine fever virus engineering platform
  2025 · 合成生物与生物制造 · African swine fever (ASF) is a deadly viral disease in domestic pigs that has a large global economic impact for the swine industry. It is present in Africa, Europe, Asia, and in the Caribbean island of Hispaniola. There…
• Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements
  2024 · 生物计算 · Sophisticated gene circuits built by synthetic biology can enable bacteria to sense their environment and respond predictably. Engineered biosensing bacteria outfitted with such circuits can potentially probe the human g…
• Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-Associated Protein and Its Utility All at Sea: Status, Challenges, and Prospects
  2024 · 深海科技 · as a defense system against invasion of viral (or other exogenous) DNA into the genome, CRISPR/Cas has ushered in a new era of functional genetics and served as a versatile genetic tool in all branches of life science. C…
• Exploring CRISPR-Cas9 HNH-Domain-Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy Simulation
  2024 · 量子材料 · The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active SpyCas9 enzyme conformation was modeled by…
• Detection of Frog Virus 3 by Integrating RPA-CRISPR/Cas12a-SPM with Deep Learning
  2023 · 深海科技 · A fast, easy-to-implement, highly sensitive, and point-of-care (POC) detection system for frog virus 3 (FV3) is proposed. Combining recombinase polymerase amplification (RPA) and CRISPR/Cas12a, a limit of detection (LoD)…
• Off-target effects in CRISPR/Cas9 gene editing
  2023 · 基因技术工具 · Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene e…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (v36, current cleaned version — June 2026). A theoretical / in-silico framework for oncological immune surveillance. The core idea —…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v32.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v30.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v30.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): Consolidated Framework v25.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveil…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 生物计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): Consolidated Framework v24.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveil…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 边缘智能 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (V39, August 2026). The question. Can Byzantine fault tolerance — building reliable systems from unreliable, independently-failing p…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 地外科学 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 地外科学 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• A Programmable Genome: A Narrative Review of CRISPR-Cas9 from Bacterial Immunity to Base and Prime Editing
  2026 · 基因技术工具 · CRISPR-Cas9 transformed genome editing from an artisanal procedure into programmable technology. This article presents a narrative review of the field's canonical line: Ishino and colleagues' 1987 observation of clustere…
• A Programmable Genome: A Narrative Review of CRISPR-Cas9 from Bacterial Immunity to Base and Prime Editing
  2026 · 基因技术工具 · CRISPR-Cas9 transformed genome editing from an artisanal procedure into programmable technology. This article presents a narrative review of the field's canonical line: Ishino and colleagues' 1987 observation of clustere…
• Bacterial Memory to Genome Surgery: A Narrative Review of the CRISPR Systems, from Repeated Sequences to Prime Editing
  2026 · 基因技术工具 · CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing-…
• Bacterial Memory to Genome Surgery: A Narrative Review of the CRISPR Systems, from Repeated Sequences to Prime Editing
  2026 · 基因技术工具 · CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing-…
• Revolutionizing the Genome: Ethical Innovations, Equitable Policies, and a Mathematical Framework for Affordable Regenerative Medicine.
  2026 · 基因技术工具 · This research presents an interdisciplinary exploration of the ethical, economic, and policy challenges shaping the future of genomics and regenerative medicine. Focusing on transformative technologies such as CRISPR gen…
• Revolutionizing the Genome: Ethical Innovations, Equitable Policies, and a Mathematical Framework for Affordable Regenerative Medicine.
  2026 · 基因技术工具 · This research presents an interdisciplinary exploration of the ethical, economic, and policy challenges shaping the future of genomics and regenerative medicine. Focusing on transformative technologies such as CRISPR gen…
• From Bacterial Immunity to Biotech Revolution: The Comprehensive History and Discovery of CRISPR Technology
  2026 · 基因技术工具 · This article provides a comprehensive overview of CRISPR technology, tracing its history from the 1987 discovery of unusual bacterial DNA repeats to its establishment as a programmable gene-editing tool. The core mechani…
• From Bacterial Immunity to Biotech Revolution: The Comprehensive History and Discovery of CRISPR Technology
  2026 · 基因技术工具 · This article provides a comprehensive overview of CRISPR technology, tracing its history from the 1987 discovery of unusual bacterial DNA repeats to its establishment as a programmable gene-editing tool. The core mechani…
• Mol.Col: A browser-based offline lipid nanoparticle formulation calculator
  2026 · 基因技术工具 · Mol.Col is a browser-based offline calculator for lipid nanoparticle (LNP) formulation, developed as part of a PhD thesis at the Faculty of Biology, Albert-Ludwigs-Universität Freiburg, conducted at the Institute for Tra…
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  2026 · 基因技术工具 · This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL…
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  2026 · 基因技术工具 · This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 生命科学 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 生命科学 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• ОБЪЯСНИМЫЕ И БЕЗОПАСНЫЕ ПЛАТФОРМЫ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА ДЛЯ ГЕНОМИКИ CRISPR: ДОСТИЖЕНИЯ, ОГРАНИЧЕНИЯ, СИСТЕМЫ МОДЕЛИРОВАНИЯ И ТРАНСЛЯЦИОННАЯ ИНТЕГРАЦИЯ НА ОСНОВЕ БЛОКЧЕЙНА
  2026 · 隐私计算与数据要素 · Искусственный интеллект (ИИ) значительно ускорил процесс редактирования генома с помощью CRISPR-Cas за счет совершенствования проектирования направляющей РНК (gRNA), прогнозирования нецелевых эффектов, оценки результатов…
• МУЛЬТИОМИЧЕСКИЙ ИИ ДЛЯ ПЕРСОНАЛИЗИРОВАННОЙ ИНТЕНСИВНОЙ ТЕРАПИИ: ОБЗОР ЦИФРОВЫХ ДВОЙНИКОВ, CRISPR И ОБЪЯСНИМЫХ СИСТЕМ
  2026 · 隐私计算与数据要素 · Персонализированная медицина меняет ситуацию, переходя от универсальных методов лечения к стратегиям, учитывающим уникальные биологические особенности каждого человека. Этот сдвиг имеет огромное значение в интенсивной те…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 量子计算 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v29.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (V39, August 2026). The question. Can Byzantine fault tolerance — building reliable systems from unreliable, independently-failing p…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (V39, August 2026). The question. Can Byzantine fault tolerance — building reliable systems from unreliable, independently-failing p…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 合成生物与生物制造 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• ITU and Microbiology: A Single-Axiom View of Bacteria, Archaea, Viruses, Phylogeny, CRISPR, AMR, Microbiome, Pandemics, and Extremophiles — Block B 2/?
  2026 · 合成生物与生物制造 · This is Tier 1 paper #27 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the second paper of Block B (Life Scienc…
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  2026 · 合成生物与生物制造 · This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL…
• ITU and Genomics: A Single-Axiom View of DNA, Human Genome Project, CRISPR Gene Editing, AlphaFold, AI Drug Discovery, Population Genetics, Coalescent Theory, and Ancient DNA — Block B 5/?, Pass-1 Final Tier 1
  2026 · 合成生物与生物制造 · This is Tier 1 paper #30 of the Information-Theoretic Unification (ITU) programme (Terada 2026; concept DOI 10.5281/zenodo.20109209; Tier 0 v3.0 at 10.5281/zenodo.20200156). It is the fifth paper of Block B and the FINAL…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (v36, current cleaned version — June 2026). A theoretical / in-silico framework for oncological immune surveillance. The core idea —…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v32.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance (formerly: Quantum-Inspired): A Theoretical Framework for Multi-Channel Independent Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance: Consolidated Framework v30.0 This document presents DQIS — a theoretical framework proposing to augment natural immune surveillance with five engineered T-…
• DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
  2026 · 合成生物与生物制造 · DQIS — Distributed Quorum-Based Independent Immune Surveillance. Consolidated Framework (V39, August 2026). The question. Can Byzantine fault tolerance — building reliable systems from unreliable, independently-failing p…
• Engineering Metabolism: How Synthetic Biology is Revolutionizing Bioproduction and Therapeutics
  2026 · 合成生物与生物制造 · This comprehensive review details the transformative synergy between synthetic biology and metabolic engineering, a collaboration that is industrializing the production of biofuels, chemicals, and therapeutics. Synthetic…
• Engineering Metabolism: How Synthetic Biology is Revolutionizing Bioproduction and Therapeutics
  2026 · 合成生物与生物制造 · This comprehensive review details the transformative synergy between synthetic biology and metabolic engineering, a collaboration that is industrializing the production of biofuels, chemicals, and therapeutics. Synthetic…
• Innovations in post-harvest disease detection: From molecular diagnostics to AI-based imaging
  2025 · 边缘智能 · Post-harvest diseases are a major contributor to global food losses, accounting for 20-50% of perishable crops, thereby threatening food security and economic stability. Traditional disease detection methods, such as vis…
• Innovations in post-harvest disease detection: From molecular diagnostics to AI-based imaging
  2025 · 边缘智能 · Post-harvest diseases are a major contributor to global food losses, accounting for 20-50% of perishable crops, thereby threatening food security and economic stability. Traditional disease detection methods, such as vis…
• Global trends and collaborative networks in plant genetic engineering （1994-2024）
  2025 · 基因技术工具 · This dataset is derived from the Web of Science (WOS) Core Collection and systematically compiles English-language research articles and reviews related to transgenic plants published globally between January 1, 1986, an…
• Genomics in plant pathogen identification and control
  2025 · 基因技术工具 · Recent advances in genomics have revolutionized plant pathogen detection and control by enabling faster and more accurate identification compared to traditional culture-based methods. Genomic tools like metagenomics and …
• Synthetic Immunology Inspired by Cross-Species Oncology: Engineering Human Cancer Immunity Through Peto's Paradox
  2025 · 合成生物与生物制造 · This conceptual article proposes a synthetic immunology approach to cancer treatment, inspired by the cross-species analysis of large, long-lived animals that exhibit natural cancer resistance — a phenomenon known as Pet…
• Synthetic Immunology Inspired by Cross-Species Oncology: Engineering Human Cancer Immunity Through Peto's Paradox
  2025 · 合成生物与生物制造 · This conceptual article proposes a synthetic immunology approach to cancer treatment, inspired by the cross-species analysis of large, long-lived animals that exhibit natural cancer resistance — a phenomenon known as Pet…
• Wearable materials with embedded synthetic biology sensors for biomolecule detection
  2021 · 生物计算 · Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits…
• CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
  2021 · 基因技术工具 · BACKGROUND: . METHODS: After conducting preclinical in vitro and in vivo studies, we evaluated the safety and pharmacodynamic effects of single escalating doses of NTLA-2001 in six patients with hereditary ATTR amyloidos…
• Wearable materials with embedded synthetic biology sensors for biomolecule detection
  2021 · 合成生物与生物制造 · Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits…
• CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
  2020 · 基因技术工具 · Transfusion-dependent -thalassemia (TDT) and sickle cell disease (SCD) are severe monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is a transcription factor that represses -globin ex…
• CRISPR–dCas13a system for programmable small RNAs and polycistronic mRNA repression in bacteria
  2023 · 合成生物与生物制造 · Bacterial small RNAs (sRNAs) function in post-transcriptional regulatory responses to environmental changes. However, the lack of eukaryotic RNA interference-like machinery in bacteria has limited the systematic engineer…
• Understanding Public Interest in CRISPR Gene Editing Across China, and the United States
  2026 · 基因技术工具 · This study investigated patterns of public interest in CRISPR gene editing by comparing online search activity in China and the United States using Google Trends data collected over a 53-week period from July 6, 2025, to…
• Understanding Public Interest in CRISPR Gene Editing Across China, and the United States
  2026 · 基因技术工具 · This study investigated patterns of public interest in CRISPR gene editing by comparing online search activity in China and the United States using Google Trends data collected over a 53-week period from July 6, 2025, to…
• Effective gene editing by high-fidelity base editor 2 in mouse zygotes
  2017 · AI 安全与对齐 · Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism …

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