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GeneTech 知识引擎共收录 139 篇相关科研实体，横跨 14 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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代表性文献（按质量分排序，前 60 条）

• Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression
  2026 · 碳中和与 CCUS · Myelodysplastic neoplasms (MDS) are heterogeneous malignancies originating in hematopoietic stem cells. In this explorative study, we carried out ultra-deep total RNA sequencing on FACS-sorted CD34+ bone marrow cells fro…
• Bacterial community profile of three Ethiopian hot springs based on 16S rRNA gene nanopore sequencing
  2025 · 地外矿物 · Ethiopia harbors a number of hot springs not yet well explored or studied using a metagenomic approach to reveal their bacterial diversity. Understanding the bacterial diversity of these ecosystems is valuable for uncove…
• Democratizing Digital Transformation: A Multisector Study of Low-Code Adoption Patterns, Limitations, and Emerging Paradigms
  2025 · 数字孪生 · Low-code development platforms (LCDPs) have emerged as transformative tools for accelerating digital transformation across industries by enabling rapid application development with minimal hand-coding. This paper synthes…
• Circular Material Flows, the Twin Transition of Manufacturing, and the Future of Labour
  2025 · 数字孪生 · In this chapter, we focus on the “twin transition” of manufacturing and the future of labour within the context of the circular economy and ocean plastics. Our point of departure is the sustainability challenges associat…
• Trypanosoma cruzi: Genomic Diversity and Structure
  2025 · 基因技术工具 · Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease, and one of the most important parasitic diseases worldwide. The first genome of T. cruzi was sequenced in 2005, and its complexity…
• CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d
  2025 · 基因技术工具 · Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage…
• The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems
  2025 · 基因技术工具 · Hemizygous genes, which are present on only one of the two homologous chromosomes of diploid organisms, have been mainly studied in the context of sex chromosomes and sex-linked genes. However, these genes can also occur…
• DASH : a versatile and high‐capacity gene stacking system for plant synthetic biology
  2025 · 合成生物与生物制造 · DNA assembly systems based on the Golden Gate method are popular in synthetic biology but have several limitations: small insert size, incompatibility with other cloning platforms, DNA domestication requirement, generati…
• Improvements in viral gene annotation using large language models and soft alignments
  2024 · AI 安全与对齐 · BACKGROUND: The annotation of protein sequences in public databases has long posed a challenge in molecular biology. This issue is particularly acute for viral proteins, which demonstrate limited homology to known protei…
• Predicting gene sequences with AI to study codon usage patterns
  2024 · AI 安全与对齐 · Selective pressure acts on the codon use, optimizing multiple, overlapping signals that are only partially understood. We trained AI models to predict codons given their amino acid sequence in the eukaryotes Saccharomyce…
• RNA-seq analysis in simulated microgravity unveils down-regulation of the beta-rhizobial siderophore phymabactin
  2024 · 地外矿物 · Abstract Exploiting the symbiotic interaction between crops and nitrogen-fixing bacteria is a simple and ecological method to promote plant growth in prospective extraterrestrial human outposts. In this study, we perform…
• miRTarBase 2025: updates to the collection of experimentally validated microRNA–target interactions
  2024 · 生物计算 · MicroRNAs (miRNAs) are small non-coding RNAs (18-26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of exper…
• Unlocking biological insights from differentially expressed genes: Concepts, methods, and future perspectives
  2024 · 生物计算 · • The first review to systematically introduce and summarize the tools for maximizing biological information of genes. • A comprehensive overview of representative tools and algorithms for analyzing differentially expres…
• Using artificial intelligence to document the hidden RNA virosphere
  2024 · 医疗人工智能 · Current metagenomic tools can fail to identify highly divergent RNA viruses. We developed a deep learning algorithm, termed LucaProt, to discover highly divergent RNA-dependent RNA polymerase (RdRP) sequences in 10,487 m…
• Identification of differentially expressed miRNAs associated with diamide detoxification pathways in Spodoptera frugiperda
  2024 · 碳中和与 CCUS · The fall armyworm (FAW) Spodoptera frugiperda is a severe economic pest of multiple crops globally. Control of this pest is often achieved using insecticides; however, over time, S. frugiperda has developed resistance to…
• A chromosome-level genome assembly of a deep-sea symbiotic Aplacophora mollusc Chaetoderma sp.
  2024 · 深海科技 · The worm-shaped, shell-less Caudofoveata is one of the least known groups of molluscs. As early-branching molluscs, the lack of high-quality genomes hinders our understanding of their evolution and ecology. Here, we repo…
• Metagenomic analysis of deep-sea bacterial communities in the Makassar and Lombok Straits
  2024 · 深海科技 · The extreme conditions of the deep-sea environment, including limited light, low oxygen levels, high pressure, and nutrient scarcity, create a natural habitat for deep-sea bacteria. These remarkable microorganisms have d…
• Improved resolution of microbial diversity in deep-sea surface sediments using PacBio long-read 16S rRNA gene sequencing
  2024 · 深海科技 · 16S rRNA gene sequencing is the gold standard for identifying microbial diversity in environmental communities. The Illumina short-read platform is widely used in marine environment studies due to its cost-effectiveness …
• A human-centric methodology for the co-evolution of operators’ skills, digital tools and user interfaces to support the Operator 4.0
  2024 · 数字孪生 · The concept of Operator 4.0 has been recently defined to evolve the modern industrial scenarios by defining a knowledge sharing process from/to operators and industrial systems, creating personalized skills, and introduc…
• OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes
  2024 · 基因技术工具 · OrthoDB (https://www.orthodb.org) offers evolutionary and functional annotations of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses, extending experimental gene function knowledge to newl…
• Multiomics of a rice population identifies genes and genomic regions that bestow low glycemic index and high protein content
  2024 · 基因技术工具 · To counter the rising incidence of diabetes and to meet the daily protein needs, we created low glycemic index (GI) rice varieties with protein content (PC) surpassing 14%. In the development of recombinant inbred lines …
• AI ‐driven adaptive learning for sustainable educational transformation
  2024 · 生命科学 · Abstract This paper scrutinizes how adaptive learning technologies and artificial intelligence (AI) are transforming today's education by making it personalized, accessible, and efficient as well as leading people to acc…
• The twin green and digital transition: High-level policy or science fiction?
  2024 · 生命科学 · This paper contributes to the literature that critically engages with the so-called ‘twin green and digital transition’ by assessing the twin transition as a policy discourse. Our research question is: why and how is the…
• Novel synthetic inducible promoters controlling gene expression during water‐deficit stress with green tissue specificity in transgenic poplar
  2024 · 合成生物与生物制造 · Synthetic promoters may be designed using short cis-regulatory elements (CREs) and core promoter sequences for specific purposes. We identified novel conserved DNA motifs from the promoter sequences of leaf palisade and …
• The genome of the deep-sea anemone Actinernus sp. contains a mega-array of ANTP-class homeobox genes
  2023 · 深海科技 · Members of the phylum Cnidaria include sea anemones, corals and jellyfish, and have successfully colonized both marine and freshwater habitats throughout the world. The understanding of how cnidarians adapt to extreme en…
• Off-target effects in CRISPR/Cas9 gene editing
  2023 · 基因技术工具 · Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene e…
• Quantifying digital innovation for the twin transition
  2025 · 数字孪生 · This paper explores the role of digital technologies for the green transition and the empirical relationships between digital innovation and environmental innovation. It develops new patent-based indicators to measure di…
• Evolution of Plasmid Mobility: Origin and Fate of Conjugative and Nonconjugative Plasmids
  2022 · AI 安全与对齐 · Conjugation drives the horizontal transfer of adaptive traits across prokaryotes. One-fourth of the plasmids encode the functions necessary to conjugate autonomously, the others being eventually mobilizable by conjugatio…
• Machine learning fromPseudomonas aeruginosatranscriptomes identifies independently modulated sets of genes associated with known transcriptional regulators
  2022 · 碳中和与 CCUS · The transcriptional regulatory network (TRN) of Pseudomonas aeruginosa coordinates cellular processes in response to stimuli. We used 364 transcriptomes (281 publicly available + 83 in-house generated) to reconstruct the…
• Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize
  2022 · 基因技术工具 · The genomic imbalance caused by varying the dosage of individual chromosomes or chromosomal segments (aneuploidy) has more detrimental effects than altering the dosage of complete chromosome sets (ploidy). Previous analy…
• A review on sox genes in fish
  2021 · AI 安全与对齐 · Abstract The Sry‐related high mobility group box ( Sox ) genes family is a group of transcription factors playing crucial roles during reproduction and development. At least 50% amino acid sequences of Sox protein family…
• A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis
  2021 · AI 安全与对齐 · Pitaya (Hylocereus) is the most economically important fleshy-fruited tree of the Cactaceae family that is grown worldwide, and it has attracted significant attention because of its betalain-abundant fruits. Nonetheless,…
• Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes
  2021 · AI 安全与对齐 · Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning…
• Genome-wide identification and characterization of Fur-binding sites in the cyanobacteria Synechocystis sp. PCC 6803 and PCC 6714
  2021 · 碳中和与 CCUS · The Ferric uptake regulator (Fur) is crucial to both pathogenic and non-pathogenic bacteria for the maintenance of iron homeostasis as well as the defence against reactive oxygen species. Based on datasets from the genom…
• Genomic Signatures Supporting the Symbiosis and Formation of Chitinous Tube in the Deep-Sea Tubeworm Paraescarpia echinospica
  2021 · 深海科技 · Vestimentiferan tubeworms are iconic animals that present as large habitat-forming chitinized tube bushes in deep-sea chemosynthetic ecosystems. They are gutless and depend entirely on their endosymbiotic sulfide-oxidizi…
• Analysis of the PEBP gene family and identification of a novelFLOWERING LOCUS Torthologue in sugarcane
  2021 · 数字孪生 · Sugarcane (Saccharum spp.) is an important economic crop for both sugar and biomass, the yields of which are negatively affected by flowering. The molecular mechanisms controlling flowering in sugarcane are nevertheless …
• A General Model to Explain Repeated Turnovers of Sex Determination in the Salicaceae
  2020 · AI 安全与对齐 · Dioecy, the presence of separate sexes on distinct individuals, has evolved repeatedly in multiple plant lineages. However, the specific mechanisms by which sex systems evolve and their commonalities among plant species …
• Distinct Expression and Methylation Patterns for Genes with Different Fates following a Single Whole-Genome Duplication in Flowering Plants
  2020 · AI 安全与对齐 · For most sequenced flowering plants, multiple whole-genome duplications (WGDs) are found. Duplicated genes following WGD often have different fates that can quickly disappear again, be retained for long(er) periods, or s…
• A chromosome-scale genome assembly of Isatis indigotica, an important medicinal plant used in traditional Chinese medicine
  2020 · 中医药工具 · Abstract Isatis indigotica (2n = 14) is an important medicinal plant in China. Its dried leaves and roots (called Isatidis Folium and Isatidis Radix, respectively) are broadly used in traditional Chinese medicine for cur…
• The Energy Transition
  2024 · 碳中和与 CCUS · The simultaneous increase in the world's population and average standard of living will lead to a rapid rise in energy demand over the next few years, making the issue of energy transition all the more complex. To a grea…
• miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
  2019 · 脑科学 · Abstract MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25 nucleotides) that negatively control expression of target genes at the post-transcriptional level. Owing to the biological significance…
• Identification and characterization of circular RNAs during the sea buckthorn fruit development
  2019 · 深海科技 · As a rising star of noncoding RNA, circular RNAs (circRNAs) have a covalently closed loop structure, which formed by 3'-5' ligation during splicing. A few circRNAs were identified and thought to be transcriptional noise …
• Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation
  2019 · 深海科技 · It is largely unknown how living organisms-especially vertebrates-survive and thrive in the coldness, darkness and high pressures of the hadal zone. Here, we describe the unique morphology and genome of Pseudoliparis swi…
• A First Study of the Virulence Potential of a Bacillus subtilis Isolate From Deep-Sea Hydrothermal Vent
  2019 · 深海科技 · Bacillus subtilis is the best studied Gram-positive bacterium, primarily as a model of cell differentiation and industrial exploitation. To date, little is known about the virulence of B. subtilis. In this study, we exam…
• Outcomes of 4 years of molecular genetic diagnosis on a panel of genes involved in premature aging syndromes, including laminopathies and related disorders
  2019 · 基因技术工具 · BACKGROUND: Segmental progeroid syndromes are a heterogeneous group of rare and often severe genetic disorders that have been studied since the twentieth century. These progeroid syndromes are defined as segmental becaus…
• Rice SPX6 negatively regulates the phosphate starvation response through suppression of the transcription factor PHR2
  2018 · AI 安全与对齐 · Phosphorus (P) is an essential macronutrient for plant growth and development, but the molecular mechanism determining how plants sense external inorganic phosphate (Pi) levels and reprogram transcriptional and adaptive …
• Insight into Genes Regulating Postharvest Aflatoxin Contamination of Tetraploid Peanut from Transcriptional Profiling
  2018 · 碳中和与 CCUS · Abstract Postharvest aflatoxin contamination is a challenging issue that affects peanut quality. Aflatoxin is produced by fungi belonging to the Aspergilli group, and is known as an acutely toxic, carcinogenic, and immun…
• The WRKY transcription factor HpWRKY44 regulates CytP450-like1 expression in red pitaya fruit (Hylocereus polyrhizus)
  2017 · AI 安全与对齐 · Red pitaya (Hylocereus polyrhizus) fruit is a high-value, functional food, containing a high level of betalains. Several genes potentially related to betalain biosynthesis, such as cytochrome P450-like (CytP450-like), ha…
• Neuroergonomics: measuring the human operator’s brain in ecological settings
  2017 · 仿生智能 · Découvrir le sommaire de ce numéro, suivre la revue par email, s'abonner... Scannez ce QR Code pour accéder à la page de ce numéro sur Cairn.info. Distribution électronique Cairn.info pour Presses Universitaires de Franc…
• De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads
  2017 · 脑科学 · Reference-quality genomes are expected to provide a resource for studying gene structure, function, and evolution. However, often genes of interest are not completely or accurately assembled, leading to unknown errors in…
• Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy
  2017 · 合成生物与生物制造 · Ubiquitous Chromatin-opening Elements (UCOEs) are defined by their ability to consistently confer stable, site of integration-independent transgene expression that is proportional to copy number, including from within re…
• An Engineered Rare Codon Device for Optimization of Metabolic Pathways
  2016 · 碳中和与 CCUS · Rare codons generally arrest translation due to rarity of their cognate tRNAs. This property of rare codons can be utilized to regulate protein expression. In this study, a linear relationship was found between expressio…
• MAGMA: Generalized Gene-Set Analysis of GWAS Data
  2015 · 生物计算 · By aggregating data for complex traits in a biologically meaningful way, gene and gene-set analysis constitute a valuable addition to single-marker analysis. However, although various methods for gene and gene-set analys…
• Biological interpretation of genome-wide association studies using predicted gene functions
  2015 · 生物计算 · The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene funct…
• Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
  2015 · 脑科学 · Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of a moderate-scale sequencing study aimed at increasing the number of genes known to contribut…
• antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
  2015 · 深海科技 · Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these meta…
• Genomic Classification of Cutaneous Melanoma
  2015 · 生命科学 · We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic clas…
• Controlling heterologous gene expression in yeast cell factories on different carbon substrates and across the diauxic shift: a comparison of yeast promoter activities
  2015 · 合成生物与生物制造 · BACKGROUND: Predictable control of gene expression is necessary for the rational design and optimization of cell factories. In the yeast Saccharomyces cerevisiae, the promoter is one of the most important tools available…
• Evolution of the Insect Desaturase Gene Family with an Emphasis on Social Hymenoptera
  2014 · AI 安全与对齐 · Desaturase genes are essential for biological processes, including lipid metabolism, cell signaling, and membrane fluidity regulation. Insect desaturases are particularly interesting for their role in chemical communicat…
• Integrated Genomic Characterization of Papillary Thyroid Carcinoma
  2014 · 生命科学 · Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and exte…

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