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GeneTech 知识引擎共收录 4272 篇相关科研实体，横跨 30 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• AI-HOPE-TGFbeta: A Conversational AI Agent for Integrative Clinical and Genomic Analysis of TGF-β Pathway Alterations in Colorectal Cancer to Advance Precision Medicine
  2025 · AI Agent 生态 · Abstract Introduction Early-onset colorectal cancer (EOCRC) is rising rapidly, particularly among Hispanic/Latino (H/L) populations, who face disproportionately poor outcomes. The TGF-β signaling pathway plays a critical…
• Nanomaterials in Precision Medicine
  2024 · 智慧农业 · The exigency for the most accurate form of diagnosis and treatment to challenge the failure of evidence-based medicine unlocked new avenues for tailored treatment. Precision Medicine encompasses the novel techniques and …
• Toward a Self-Learning AI Agent for Drug Repurposing: Building Human-Scale Representations for Virtual Patients
  2026 · AI Agent 生态 · Virtual patients need a useful coordinate system before they can model patient-specific dynamics. Most models in AI for science operate at molecular, cellular, or organ-specific scales. However, treatment decisions are m…
• Metastatic Epithelioid Trophoblastic Tumor Following Incomplete Methotrexate Therapy for Ectopic Pregnancy: A Case Report and Multimodal Management.
  2026 · AI Agent 生态 · Gestational trophoblastic neoplasia (GTN) comprises a spectrum of rare placental trophoblastic malignancies, including choriocarcinoma, placental site trophoblastic tumor, and the particularly uncommon epithelioid tropho…
• An AI-Powered Metadata-Driven File Management Agent for Academic Computing Platforms
  2026 · AI Agent 生态 · The rapid growth of digital files in the academic environment has accelerated the challenges of manual file organization, resulting in an unorganized desktop, inefficient storage, and reduced productivity. This study pre…
• DEVELOPMENT AND EVALUATION OF POLYHERBAL EMULGEL FOR MANAGEMENT OF DIABETIC WOUND HEALING
  2026 · AI Agent 生态 · Diabetic wounds are difficult to heal because hyperglycemia keeps the wound in a prolonged inflammatory state, increases oxidative stress, promotes infection, and delays collagen formation and re-epithelialization Diabet…
• DEVELOPMENT AND EVALUATION OF POLYHERBAL EMULGEL FOR MANAGEMENT OF DIABETIC WOUND HEALING
  2026 · AI Agent 生态 · Diabetic wounds are difficult to heal because hyperglycemia keeps the wound in a prolonged inflammatory state, increases oxidative stress, promotes infection, and delays collagen formation and re-epithelialization Diabet…
• AI-HOPE: an AI-driven conversational agent for enhanced clinical and genomic data integration in precision medicine research
  2025 · AI Agent 生态 · Abstract Motivation The growing complexity of clinical cancer research has fueled a surge in demand for automated bioinformatics tools capable of integrating clinical and genomic data to accelerate discovery efforts. Res…
• An Endostatin-Lentivirus (ES-LV)-EPC Gene Therapy Agent for Suppression of Neovascularization in Oxygen-Induced Retinopathy Rat Model
  2020 · AI Agent 生态 · Abstract Background: Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy. This study aimed to investi…
• An Endostatin-Lentivirus (ES-LV)-EPC Gene Therapy Agent for Suppression of Neovascularization in Oxygen-Induced Retinopathy Rat Model
  2020 · AI Agent 生态 · Abstract Background: Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy. This study aimed to investi…
• AI-HOPE: An AI-Driven conversational agent for enhanced clinical and genomic data integration in precision medicine research
  2024 · AI Agent 生态 · Abstract Introduction: The increasing complexity of clinical cancer research necessitates the development of automated tools capable of integrating clinical and genomic data while accelerating discovery efforts. Artifici…
• An Endostatin-Lentivirus (ES-LV)-EPC Gene Therapy Agent for Suppression of Neovascularization in Oxygen-Induced Retinopathy Rat Models
  2019 · AI Agent 生态 · Abstract Background: Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for neovascularization but not ocular disease therapy. This study aimed to investigate the efficacy …
• The Role of Resveratrol in Cancer Therapy
  2017 · AI Agent 生态 · Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, inc…
• A review of recent sensing technologies to detect invertebrates on crops
  2016 · 智慧农业 · Precision agriculture needs integrated pest management (IPM), for which detection and identification of target invertebrate species is a prerequisite. Researchers have been developing various technologies to detect pests…
• Flowering estimation in apple orchards by image analysis
  2013 · 智慧农业 · Tree-specific management practice related to individual tree physiological condition is necessary for higher quality and quantity in apple fruit production. Detection of apple flowering abundance based on analysis of HSL…
• Wireless-and-GPS system for cotton fiber-quality mapping
  2011 · 智慧农业 · A system including wireless-communication and GPS technologies was designed, constructed and field tested to enable site-specific crop management in cotton production in the form of fiber-quality mapping. The system is c…
• AERO: An AI Agent for Adaptive Eligibility Refinement and Optimization of Clinical Trial Criteria in Real-World Trial Emulation
  2026 · AI Agent 生态 · Randomized controlled trials (RCTs) provide high internal validity but often rely on restrictive eligibility criteria that limit generalizability and complicate real-world trial emulation. We propose AERO (AI Agent for A…
• An Agentic, No Code Artificial Intelligence Workflow for Developing and Externally Validating a Thyroid Nodule Ultrasound Malignancy Classifier
  2026 · AI Agent 生态 · Convolutional neural networks (CNNs) can classify thyroid nodules on ultrasound, yet published models are seldom available for independent testing, require machine-learning expertise to develop and deploy, and are valida…
• spatiAlytica: Viewer-Grounded Multimodal Agentic System for Interactive Spatial Omics Analysis
  2026 · AI Agent 生态 · Spatial transcriptomics and proteomics map tissue architecture and cellular interactions, but analysis remains limited by programming demands and text-centered AI agents that lack viewer grounding and cross-turn context.…
• Laboratory Toxicity and Field Efficacy of Four Microbial-Derived Pesticides Combined with Two Adjuvants Against <i>Lygus pratensis</i> (Hemiptera: Miridae).
  2026 · AI Agent 生态 · Systematic field data on adjuvant-amended microbial-derived pesticides against L. pratensis in arid, high-ultraviolet cotton regions remain scarce. This study systematically evaluated the laboratory toxicity and field ef…
• Total Flavonoids from <i>Carthamus tinctorius</i> L. Reduce Liver Fibrosis by Influencing Autophagy via Hedgehog Signaling.
  2026 · AI Agent 生态 · Liver fibrosis is a critical determinant of the progression of chronic liver disease (CLD). Total flavonoids from Carthamus tinctorius L. (TFCTLs) exhibit diverse pharmacological activities while their effect on liver fi…
• Research on the Highly Efficient and Low-Dose Improvement of Alcohol-Induced Liver Injury by High-Selenium-Content Modified Lycium barbarum Polysaccharides.
  2026 · AI Agent 生态 · There are currently no FDA-approved drugs for the treatment of alcohol-related liver diseases (ALD) due to their lack of effectiveness. Selenium-modified Lycium barbarum polysaccharides (SeLBP), as a promising agent for …
• A Conversational Multi-Agent AI System for Integrated Multi-Omics Analysis and Biomedical Discovery
  2026 · AI Agent 生态 · Single-cell and spatial omics offer unprecedented opportunities to decipher the mechanisms of disease, however, this process requires teams of experts, iterative trial-and-error and reasoning across modalities. Here we p…
• RadGuide AI: Development and Technical Evaluation of a General Nuclear Medicine Agent for Traceable Radiopharmaceutical Decision Support
  2026 · AI Agent 生态 · Background Nuclear medicine and radiopharmaceutical development require coordinated radiochemistry, dosimetry, molecular imaging, radiation-safety and clinical decision processes. Current workflows remain fragmented, dif…
• HistAgent: an evidence-grounded agent for spatial molecular reasoning from routine histology
  2026 · AI Agent 生态 · Abstract Routine hematoxylin and eosin (H&E) staining is a widely used histology test in clinical practice and biomedical research, but it does not provide direct spatial molecular information. Spatial transcriptomics (S…
• Robust AI Framework for Comprehensive Tuberculosis Drug Resistance Profiling with Rapid Adaptability
  2026 · AI Agent 生态 · Tuberculosis remains the leading cause of death from a single infectious agent, with drug-resistant tuberculosis, particularly multidrug-resistant and extensively drug-resistant strains, posing major challenges for timel…
• Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations.
  2026 · AI Agent 生态 · The landscape of drug delivery is undergoing a transformative shift. As demand for large-volume subcutaneous (SC) biologics continues to surge, the race to develop smarter, patient-centered combination drug products has …
• Navigating the Evolution of Urothelial Carcinoma Treatment: From Chemotherapy to Immunotherapy.
  2026 · AI Agent 生态 · Background The urothelial carcinoma (UC) trial landscape has expanded over two decades, alongside a shift from chemotherapy to immunotherapy and targeted approaches. We characterized temporal patterns in trial phase, int…
• Message Humanness as a Predictor of AI's Perception as Human: Secondary Data Analysis of the HeartBot Study.
  2026 · AI Agent 生态 · Background Artificial intelligence (AI) chatbots have become prominent tools in health care to enhance health knowledge and promote healthy behaviors across diverse populations. However, factors influencing the perceptio…
• Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives.
  2026 · AI Agent 生态 · Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the efficacy and safety of cancer treatment. Despite substantial preclinical pot…
• Engagement, Satisfaction, and Therapeutic Alliance With an AI Conversational Agent for Parents: Quantitative Descriptive Study.
  2026 · AI Agent 生态 · Background Parent management training (PMT) is an evidence-based intervention for addressing child behavioral difficulties; however, caregivers often need additional guidance when implementing skills in daily life. Pat i…
• Simultaneous Determination of Total and Unbound Amphotericin B by LC-MS/MS: Application to Protein Binding Analysis.
  2026 · AI Agent 生态 · Amphotericin B (AmB), a first-line antifungal agent, is highly protein-bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on …
• BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering
  2026 · AI Agent 生态 · ABSTRACT Clinical studies of chimeric antigen receptor (CAR)-T therapy generate diverse molecular and clinical evidence that remains fragmented across publications, public repositories and patient-derived datasets, limit…
• Neurosymbolic Multi-Agent Large Language Model System Versus Specialist Physicians in COPD and Asthma Management: A Comparative Performance Evaluation Using Guideline-Based Clinical Vignettes
  2026 · AI Agent 生态 · Abstract Background Chronic obstructive pulmonary disease (COPD) and asthma collectively affect over 500 million individuals worldwide and represent leading causes of respiratory-related morbidity, healthcare utilization…
• [Analysis on the incidence and perioperative outcomes of immune-related adverse events in preoperative immunotherapy for colorectal cancer based on multicenter real-world data].
  2026 · AI Agent 生态 · Objective: To investigate the incidence of immune-related adverse events (irAEs) and corresponding perioperative outcomes among patients with colorectal cancer who received neoadjuvant immunotherapy and underwent curativ…
• Cisplatin resistance in oral squamous cell carcinoma: mechanisms, reversal strategies, and emerging technologies.
  2026 · AI Agent 生态 · Cisplatin remains a first-line chemotherapeutic agent in the treatment of oral squamous cell carcinoma (OSCC). However, the efficacy of cisplatin is frequently compromised by the development of drug resistance. This revi…
• Expanding the Toolbox: Utility of HistioTrak for Minimal Residual Monitoring in Pediatric Patients with Langerhans Cell Histiocytosis Treated with Targeted Therapy.
  2026 · AI Agent 生态 · Background/Objectives : Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the clonal proliferation of Langerhans-like dendritic cells and constitutive activation of the mitogen-activated pro…
• Predicting postoperative malignancy upgrading in B1-B3 breast lesions: combined utility of conventional ultrasound and contrast-enhanced ultrasound features.
  2026 · AI Agent 生态 · Background While conventional ultrasound (US)-guided core needle biopsy (CNB) is routinely used for preoperative diagnosis of breast lesions, it is susceptible to false negatives and underestimation, especially in B1-B3 …
• Global research on the crosstalk between microbiota - intratumoral microorganisms and liver cancer: a visualization analysis.
  2026 · AI Agent 生态 · BACKGROUND: In the past few decades, the field of microbiota research has experienced rapid development and growth. We have employed bibliometric methods to comprehensively visualize and analyze the global knowledge and …
• Optimization of temporal phase in multi-phase contrast-enhanced MRI for gross tumor volume determination in pancreatic cancer radiotherapy.
  2026 · AI Agent 生态 · Background Pancreatic cancer is characterized by an insidious onset and rapid progression, and the accurate determination of the gross tumor volume (GTV) constitutes a critical prerequisite for ensuring the efficacy of r…
• The neurological adverse events of immune check point inhibitors in the treatment of cancer.
  2026 · AI Agent 生态 · Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment with significant improvements in survival rates. With the increase in ICI use in the clinical setting, several case reports and series h…
• Variation in uptake and dose reduction of CDK4/6 inhibitors for the treatment of breast cancer in England, 2019–2024: a descriptive observational study using OpenPrescribing Hospitals
  2026 · AI Agent 生态 · Background The number of novel cancer therapies approved for use in England by the National Institute for Health and Care Excellence is increasing. Monitoring the adoption of new therapies is important to assess equity o…
• Time to antibiotic administration in intra-amniotic infections: impact of cefoxitin monotherapy versus traditional antibiotic therapy.
  2026 · AI Agent 生态 · Objective This study addresses treatment of intra-amniotic infection (IAI) by comparing timely receipt of recommended antibiotic administration between cefoxitin and traditional antimicrobial therapy, ampicillin and gent…
• Application of immune checkpoint inhibitors in hepatocellular carcinoma: a landscape analysis of clinical trial databases.
  2026 · AI Agent 生态 · Background Hepatocellular carcinoma (HCC) is a leading global malignant tumor with poor prognosis. Immune checkpoint inhibitors (ICIs) have become a breakthrough treatment for HCC, but a systematic landscape analysis of …
• FLT3 Testing and Guideline Concordance in Acute Myeloid Leukemia Across a Community Health System.
  2026 · AI Agent 生态 · Introduction FMS-like tyrosine kinase 3 (FLT3) mutations are present in approximately one-third of patients with acute myeloid leukemia (AML) and are associated with higher relapse and reduced survival. National Comprehe…
• A pan-cancer atlas of metabolic regulatory circuitries integrating multi-omic, immune, and clinical dimensions.
  2026 · AI Agent 生态 · Introduction Metabolic reprogramming is a central determinant of tumor progression, immune evasion, and susceptibility to regulated cell death. However, the integration of metabolic regulation across genomic, multi-omic,…
• Protocatechuic Acid Alleviates D-Gal-Induced Renal Senescence and Injury in Mice by Regulating Taurine Metabolism.
  2026 · AI Agent 生态 · Protocatechuic acid (PCA), a natural phenolic compound with antioxidant and anti-inflammatory properties, has been proposed as a potential therapeutic agent against aging-related diseases. This study investigated the pro…
• Breaking Through the Limits: Nanomedicine at the Service of New Drug Combinations to Tackle Pancreatic Cancer.
  2026 · AI Agent 生态 · Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive cancers, with a poor prognosis due to late diagnosis and resistance to chemotherapy. Gemcitabine (GEM) monotherapy was the gold standard treatment for …
• Analysis of nutritional components and flavor compounds in naturally fermented, fermentation agent-fermented, and unfermented multi-grain pancakes.
  2026 · AI Agent 生态 · Traditional northern Chinese pancake fermentation faces challenges such as inconsistency, prolonged processing duration, and safety hazards. A controlled co-fermentation system (YL-7) was applied to multigrain pancakes f…
• <i>Gymnema sylvestre</i> as a Multi-Target Antidiabetic Agent: Mechanistic Insights and Metabolic Regulation.
  2026 · AI Agent 生态 · Diabetes mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia and represents a major global public health concern due to its rapidly increasing prevalence. Although current pharmacological…
• Drug repurposing of sophoridine for sepsis-induced organ injury: from in-depth analysis of a single agent to a multi-target therapeutic paradigm.
  2026 · AI Agent 生态 · Sepsis-induced immune dysregulation and multiple organ dysfunction present formidable clinical challenges that conventional single-target therapies fail to address. This review evaluates the potential of the natural quin…
• Research Progress on Pathogenesis of Diabetic Nephropathy and Intervention with Traditional Chinese Medicine.
  2026 · AI Agent 生态 · Diabetic kidney disease (DKD) is the most prevalent microvascular complication of diabetes mellitus and the leading cause of chronic kidney disease and end-stage renal disease, with its global incidence rising continuous…
• RareCure: An Open-Source Artificial Intelligence Pipeline for Context-Adaptive Treatment Discovery in Rare Solid Tumors.
  2026 · AI Agent 生态 · Background Rare cancers account for approximately 25-30% of cancer diagnoses in the United States, yet precision-oncology infrastructure has been built primarily for common tumor types. Soft tissue sarcomas exemplify thi…
• Phytotherapeutic potential of Gossypium barbadense L. root as an alternative therapy for colitis: a comprehensive review with network pharmacology insights.
  2026 · AI Agent 生态 · Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), remains a major global health challenge characterized by chronic, relapsing inflammation of the colonic mucosa. Although conventional pharmacotherap…
• A review on in-silico analysis of immune cell trafficking and interactions with the tumour microenvironment.
  2026 · AI Agent 生态 · The tumour microenvironment (TME) contains a diverse mix of cells and components, including cancer cells, immune cells, connective tissue, and biochemical factors; all of these are constantly interacting as well as influ…
• Genomic innovation in precision oncology: integrated CRISPR-TTP bioengineering architecture for Ewing Sarcoma (version 4.0 - complete architectural specification).
  2026 · AI Agent 生态 · Background Metastatic Ewing Sarcoma remains a critical therapeutic challenge with 5-year survival below 30%. The EWSR1-FLI1 fusion oncogene is undruggable by conventional approaches, requiring integrated bioengineering s…
• Beyond the Genomic Storm: Evaluating Tabernanthalog as a Potential Scaffold for Silent Neuroplasticity and Broad-Spectrum Therapy.
  2026 · AI Agent 生态 · The clinical renaissance of psychedelic medicine has highlighted the therapeutic potential of rapid-acting neuroplastogens, or "psychoplastogens," for psychiatric disorders. However, the widespread application of classic…
• Take Five: harmonization in personalized cancer vaccines for cancer immunotherapy.
  2026 · 智慧农业 · Precision medicine provides a therapeutic framework that addresses the interindividual diversity in tumor genetics, immunological determinants of disease, and immune responsiveness. Among precision approaches, personaliz…
• Nanotechnology-based immunotherapy: integrating Artificial Intelligence (AI) with current strategies in combating brain cancer disease.
  2026 · 智慧农业 · Brain cancer is one of the most challenging malignancies and a major contributor to worldwide morbidity and mortality. Glioblastoma, the most aggressive adult brain tumor, is associated with poor prognosis despite conven…
• Comparative genomics and reproductive mechanisms of fertility in cattle and camels: Implications for assisted reproduction and precision breeding.
  2026 · 智慧农业 · Fertility limits productivity in cattle and camels. Bovine fertility genomics is advanced, but determinants of fertility in camels remain poorly defined. Advances in long-read assemblies, transcriptomics, multi-omics, an…

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