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GeneTech 知识引擎共收录 258 篇相关科研实体，横跨 16 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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代表性文献（按质量分排序，前 60 条）

• Neuroblastoma in Childhood: Biological Insights, Risk Stratification, and Advances in Multimodal Therapy
  2026 · 生物计算 · Neuroblastoma is the most common extracranial solid tumor of childhood and remains a leading cause of cancer-related mortality in pediatric patients. Characterized by marked clinical and biological heterogeneity, the dis…
• Artificial intelligence–based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality
  2026 · 医疗人工智能 · BACKGROUND AND AIMS: Women are underdiagnosed and undertreated for cardiovascular disease (CVD). Automatic quantification of breast arterial calcification (BAC) on screening mammography can identify women at risk for CVD…
• Electrocardiographic Signatures of Dysglycaemia: Mechanistic Foundations, Digital Biomarkers, and Artificial Intelligence for Non-Invasive Diabetes Risk Stratification
  2026 · 医疗人工智能 · Diabetes mellitus is projected to affect more than 1.3 billion people worldwide by 2050, with millions remaining undiagnosed or in a prediabetic state. Cardiovascular complications account for nearly half of diabetes-rel…
• Alzheimer's disease drug development pipeline: 2026.
  2026 · 脑科学 · INTRODUCTION: Discovery and development of new therapies for Alzheimer's disease (AD) are urgently needed to address the world's growing population of individuals on the AD pathophysiological continuum. Clinicaltrials.go…
• Brucellosis: The Great Mimicker Presenting as Acute Myocarditis and Pyrexia of Unknown Origin in Dhaka, Bangladesh
  2026 · 碳中和与 CCUS · Background: Brucellosis is a pervasive zoonotic disease transmissible from vertebrate animals to humans. Despite dietary habits that typically contain unpasteurized milk, close contact with cattle during religious festiv…
• Use of the Teach-Back Method in Adults with Cardiovascular Disease: A Scoping Review
  2026 · 碳中和与 CCUS · Background: Teach-Back is a structured communication strategy increasingly used in patient education to enhance understanding and self-management, particularly among people with complex chronic conditions such as cardiov…
• Prevalence of complications for type 2 diabetes mellitus among patients visiting the diabetes clinic at azadi teaching hospital: a cross-sectional study
  2026 · 碳中和与 CCUS · Diabetes mellitus, commonly referred to as DM, is a chronic illness that can no longer develop or be transmitted as an epidemic. The research study aims to ascertain the frequency of type 2 diabetes mellitus complication…
• AÇÃO EXTENSIONISTA: UM ESTUDO ACERCA DA EDUCAÇÃO EM SAÚDE SOBRE O CÂNCER DO COLO DO ÚTERO
  2026 · 碳中和与 CCUS · Este e-book reúne experiências extensionistas que revelam a potência formativa, científica e social da Biomedicina no Extremo Sul da Bahia, articulando ensino, pesquisa e compromisso com a realidade local.Ao narrar proje…
• Shaping the future of multiple myeloma with artificial intelligence and digital twins: from concept to clinic
  2026 · 数字孪生 · Multiple myeloma (MM) is an incurable hematological malignancy with significant clinical and biological heterogeneity. Despite development and refinement of numerous prognostic models for MM, challenges with accurate and…
• Integrating Molecular Pathogenesis and Host Response into a Digital Twin Framework for Predicting Therapeutic Outcomes in <i>Balamuthia mandrillaris</i> Encephalitis.
  2026 · 数字孪生 · High Resolution Image Download MS PowerPoint Slide Balamuthia mandrillaris is a free-living amoeba that causes granulomatous amoebic encephalitis, a rare but devastating central nervous system infection with mortality ex…
• Predicting Alzheimer progression using EEG-based digital twins
  2026 · 数字孪生 · Early and accurate prognosis of Alzheimer’s disease (AD) remains limited by current biomarkers, which are often invasive, require expensive equipment, or fail to predict individual trajectories of cognitive decline. In t…
• A review of AI-based radiogenomics in neurodegenerative disease
  2025 · AI 安全与对齐 · Neurodegenerative diseases are chronic, progressive conditions that cause irreversible damage to the nervous system, particularly in aging populations. Early diagnosis is a critical challenge, as these diseases often dev…
• Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis
  2025 · AI 安全与对齐 · Parkinson's disease is a prevalent neurodegenerative disorder, where early diagnosis is essential for slowing disease progression and optimizing treatment strategies. The latest developments in artificial intelligence (A…
• From Dysbiosis to Prediction: AI-Powered Microbiome Insights into IBD and CRC
  2025 · AI 安全与对齐 · Recent advances in the integration of artificial intelligence (AI) and microbiome analysis have expanded our understanding of gastrointestinal diseases, particularly in inflammatory bowel disease (IBD), colitis-associate…
• Breast cancer: pathogenesis and treatments
  2025 · AI 安全与对齐 · Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breas…
• Artificial Intelligence-Driven Neuromodulation in Neurodegenerative Disease: Precision in Chaos, Learning in Loss
  2025 · AI 安全与对齐 · Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are marked by progressive network dysfunction that challenges conventional, protocol-based neurorehabili…
• Advancing Neurodegenerative Disease Management: Technical, Ethical, and Regulatory Insights from the NeuroPredict Platform
  2025 · AI 安全与对齐 · On a worldwide scale, neurodegenerative diseases, including multiple sclerosis, Parkinson’s, and Alzheimer’s, face considerable healthcare challenges demanding the development of novel approaches to early detection and e…
• 2025 ESC/EACTS Guidelines for the management of valvular heart disease
  2025 · 生物计算 · The European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) Guidelines represent the views of the ESC and the EACTS and were produced after careful consideration of the scientific an…
• The China Alzheimer Report 2025
  2025 · 生物计算 · With the sustained growth of the economy and significant changes in social demographics, the issue of elderly-related diseases has increasingly drawn attention, particularly. Alzheimer's disease (AD), as a representative…
• Consensus on the diagnosis and treatment of adult necrotizing fasciitis (2025 edition)
  2025 · 生物计算 · Abstract Necrotizing fasciitis (NF) is a disease characterized by severe infection of the skin and its underlying soft tissues as the initial symptom. NF is known for its difficulty in early diagnosis and rapid progressi…
• How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies
  2025 · 生物计算 · BACKGROUND: Recent basic biological research found that obesity accelerates biological aging and increases cardiovascular disease (CVD) risk. However, there is still a lack of real-world population evidence. This study a…
• Obesity and Its Comorbidities: Current Treatment Options, Emerging Biological Mechanisms, Future Perspectives and Challenges
  2025 · 生物计算 · Obesity is a chronic, multifactorial disease and a major global public health challenge. Defined by excessive fat accumulation, obesity significantly increases the risk of numerous diseases, including type 2 diabetes mel…
• Opportunistic Detection of Coronary Artery Calcium on Noncardiac Chest Computed Tomography: An Emerging Tool for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association
  2025 · 生物计算 · Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis that confers increased risk of atherosclerotic cardiovascular disease. Measured by noncontrast cardiac computed tomography, CAC improves risk strat…
• Global evolution of inflammatory bowel disease across epidemiologic stages
  2025 · 生物计算 · During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1. At the turn of the twenty-first century, IBD incidence increa…
• Clinical neurocardiology: defining the value of neuroscience‐based cardiovascular therapeutics – 2024 update
  2025 · 生物计算 · The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to …
• Artificial intelligence in cardiovascular diagnostics: a systematic review and descriptive analysis of clinical applications and diagnostic performance
  2025 · 医疗人工智能 · INTRODUCTION: Artificial intelligence (AI) is rapidly transforming cardiovascular diagnostics by enhancing early disease detection, risk stratification, and clinical decision-making. Recent studies have shown the effecti…
• Artificial Intelligence in Chronic Disease Management for Aging Populations: A Systematic Review of Machine Learning and NLP Applications
  2025 · 医疗人工智能 · As China's elderly population grows rapidly and the aging society arrives, the number of elderly patients with chronic diseases (mainly including chronic cardiovascular and cerebrovascular diseases, respiratory diseases,…
• Artificial Intelligence in Multi-Disease Medical Diagnostics: An Integrative Approach
  2025 · 医疗人工智能 · With advanced algorithms, artificial intelligence (AI) has revolutionized the medical diagnostic field where diseases can be predicted simultaneously. The integrative nature of this approach is novel because it can bette…
• Wearable sleep recording augmented by artificial intelligence for Alzheimer’s disease screening
  2025 · 医疗人工智能 · The recent emergence of wearable devices will enable large scale remote brain monitoring. This study investigated whether multimodal wearable sleep recordings could help screening for Alzheimer's disease (AD). Measuremen…
• Applications of artificial intelligence in early childhood health management: a systematic review from fetal to pediatric periods
  2025 · 医疗人工智能 · Background: The integration of artificial intelligence (AI) into early childhood health management has expanded rapidly, with applications spanning the fetal, neonatal, and pediatric periods. While numerous studies repor…
• Role of Artificial Intelligence in Congenital Heart Disease and Interventions
  2025 · 医疗人工智能 · Artificial intelligence has promising impact on patients with congenital heart disease, a vulnerable population with life-long health care needs and, often, a substantially higher risk of death than the general populatio…
• Integrating artificial intelligence and optogenetics for Parkinson’s disease diagnosis and therapeutics in male mice
  2025 · 医疗人工智能 · Parkinson's disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optoge…
• Applications of Artificial Intelligence for the Prediction and Diagnosis of Cancer Therapy-Related Cardiac Dysfunction in Oncology Patients
  2025 · 医疗人工智能 · Cardiovascular diseases and cancer are the leading causes of morbidity and mortality in modern society. Expanding cancer therapies that have improved prognosis may also be associated with cardiotoxicity, and extended lif…
• From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease
  2025 · 医疗人工智能 · Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn's disease, is a chronic inflammatory condition with global prevalence and varying incidence. The IBD pathogenesis involves intricate interactions …
• Applications of Endovascular Brain-Computer Interface in Patients with Alzheimer's Disease.
  2025 · 仿生智能 · Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder affecting the elderly, leading to important impairments in cognitive function and the ability to live independently. This results in substantial disabili…
• Brain organoid model systems of neurodegenerative diseases: recent progress and future prospects
  2025 · 仿生智能 · Neurological diseases are a leading cause of disability, morbidity, and mortality, affecting 43% of the world's population. The detailed study of neurological diseases, testing of drugs, and repair of site-specific defec…
• Brain photobiomodulation: a potential treatment in Alzheimer’s and Parkinson’s diseases
  2025 · 仿生智能 · Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases, characterized by the progressive loss of synapses and neurons, leading to cognitive and motor decline. Their pathophysiology in…
• A novel approach to the prevention and management of cardiovascular diseases: targeting brain–heart axis
  2025 · 仿生智能 · Epidemiological studies indicate that cardiovascular diseases are the leading cause of death and disability worldwide, imposing a significant socioeconomic burden. Despite continuous medical advancements and new preventi…
• Clinical neurocardiology: defining the value of neuroscience‐based cardiovascular therapeutics – 2024 update
  2025 · 脑科学 · The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to …
• Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies
  2025 · 脑科学 · Cancer neuroscience has evolved as a novel discipline that elucidates the intricate relationships between the neurological system and neoplasms. Research indicates that the ablation of particular nerve types, including p…
• Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
  2025 · 脑科学 · By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug-resistant epilepsies, including developmental and epileptic encephalopathies. Unlike con…
• The top 100 most cited publications on astrocytes in Alzheimer’s disease from 2000 to 2025: a bibliometric analysis
  2025 · 脑科学 · Background The pathogenesis of Alzheimer’s disease (AD) is closely linked to astrocytes. This study conducts a bibliometric analysis of data from a wide range of literature in this field to enhance the in-depth understan…
• Recent advances (2022–2024) in eye-tracking for Parkinson’s disease: a promising tool for diagnosing and monitoring symptoms
  2025 · 脑科学 · Introduction: Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders, characterized by both motor and non-motor symptoms, including impaired oculomotor functions. Eye-tracking technology, a pre…
• The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
  2025 · 脑科学 · More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due…
• Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research
  2025 · 脑科学 · The Chilean degu (Octodon degus) is a medium sized, long-lived rodent with traits that make them a natural model for neuroscience research. Their social behaviors, diurnality, and extended developmental time course, when…
• Synapses-associated research in Parkinson’s disease: an explored trends analysis
  2025 · 脑科学 · Background The pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein ( α -Syn) and extensive neurodegeneration. Synaptic dysfunction is a key…
• Redefining Non-Motor Symptoms in Parkinson’s Disease
  2025 · 脑科学 · Parkinson's disease involves widespread neurodegeneration that extends far beyond the basal ganglia, giving rise to a diverse range of non-motor symptoms that frequently emerge before motor onset. These include autonomic…
• Multicarrier Nanoplatforms for Precise Targeting of Cellular Energy Centers in Ischemic Heart Disease Therapy
  2025 · 碳中和与 CCUS · High Resolution Image Download MS PowerPoint Slide Mitochondria, as the core organelle of cellular energy metabolism and fate regulation, not only maintain the balance between myocardial reactive oxygen species ROS and e…
• Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management
  2025 · 碳中和与 CCUS · Acute myocardial infarction (AMI) is a cardiovascular disease characterized by myocardial necrosis resulting from acute coronary artery occlusion. Although standardized diagnostic and therapeutic protocols have markedly …
• Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care
  2025 · 数字孪生 · Digital twins - personalized, data-driven computational models - are emerging as a powerful paradigm for representing and predicting disease trajectories at the individual level. These models have the potential to suppor…
• The translational power of Alzheimer’s-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history
  2025 · 数字孪生 · Alzheimer’s disease (AD) is a complex neurodegenerative condition characterized by a multifaceted interplay of genetic, environmental, and pathological factors. Traditional diagnostic and research methods, including neur…
• Genomics in Epidemiology and Disease Surveillance: An Exploratory Analysis
  2025 · 基因技术工具 · Genomics has revolutionized epidemiology and disease surveillance by providing powerful tools for identifying, tracking, and analyzing pathogens at the molecular level. This exploratory analysis examines the integration …
• Meeting report – Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases
  2025 · 生命科学 · Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in …
• Early life gut microbiome and its impact on childhood health and chronic conditions
  2025 · 生命科学 · The development of the gut microbiome is crucial to human health, particularly during the first three years of life. Given its role in immune development, disturbances in the establishment process of the gut microbiome m…
• Predictive analysis of heart disease using quantum-assisted machine learning
  2025 · 量子材料 · Coronary heart disease (CHD) is a severe cardiac disease, and hence, its early diagnosis is essential as it improves treatment results and saves money on medical care. The prevailing development of quantum computing and …
• AI-DRIVEN ENVIRONMENTAL HEALTH DISEASE MODELING: A REVIEW OF TECHNIQUES AND THEIR IMPACT ON PUBLIC HEALTH IN THE USA AND AFRICAN CONTEXTS
  2024 · AI 安全与对齐 · This scholarly paper embarks on an exploratory journey into the realm of AI-driven environmental health disease modeling, with a keen focus on its implications in the diverse healthcare landscapes of the USA and Africa. …
• Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
  2024 · 生物计算 · The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzh…
• Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets
  2024 · 生物计算 · Programmed cell death represents a precisely regulated and active cellular demise, governed by a complex network of specific genes and proteins. The identification of multiple forms of programmed cell death has significa…
• Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System
  2024 · 生物计算 · Population aging is one of the most important demographic transformations of our time. Increasing the "health span"-the proportion of life spent in good health-is a global priority. Biological aging comprises molecular a…
• Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
  2024 · 生物计算 · BACKGROUND: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expecta…

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