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cell biology

GeneTech 知识引擎共收录 215 篇相关科研实体，横跨 17 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design
  2026 · AI 安全与对齐 · The continued threat of zoonotic coronavirus spillovers underscores the need for cross-species applicable vaccine design strategies. The genus Embecovirus includes human coronaviruses OC43 and HKU1 as well as relevant ve…
• Left ventricular hypertrophy as a predictor of adverse maternal and neonatal outcomes in chronic hypertension in pregnancy: a multicenter study
  2026 · 医疗人工智能 · The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear. This multicenter retrospective cohort study included pregnant w…
• Left ventricular hypertrophy as a predictor of adverse maternal and neonatal outcomes in chronic hypertension in pregnancy: a multicenter study
  2026 · 医疗人工智能 · The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear. This multicenter retrospective cohort study included pregnant w…
• Evaluation of supervised machine learning models in predicting temporomandibular joint disc displacement on 3T magnetic resonance imaging
  2026 · 医疗人工智能 · To evaluate supervised machine learning (ML) models for classifying temporomandibular joint (TMJ) disc displacement on MRI using morphometric and signal intensity features. This retrospective study analyzed 324 TMJs from…
• Evaluation of supervised machine learning models in predicting temporomandibular joint disc displacement on 3T magnetic resonance imaging
  2026 · 医疗人工智能 · To evaluate supervised machine learning (ML) models for classifying temporomandibular joint (TMJ) disc displacement on MRI using morphometric and signal intensity features. This retrospective study analyzed 324 TMJs from…
• Frequency-dependent aggregate structures and dynamic behaviour of magnetic cubic particles in a rotating magnetic field
  2026 · 脑科学 · We investigated dimensionality-dependent aggregate formation and structural transitions of magnetic cubic particles in a rotating magnetic field using three-dimensional Brownian dynamics simulations. Unlike quasi-two-dim…
• Frequency-dependent aggregate structures and dynamic behaviour of magnetic cubic particles in a rotating magnetic field
  2026 · 脑科学 · We investigated dimensionality-dependent aggregate formation and structural transitions of magnetic cubic particles in a rotating magnetic field using three-dimensional Brownian dynamics simulations. Unlike quasi-two-dim…
• Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma
  2026 · 脑科学 · Abstract Thoracic trauma is a major contributor to morbidity in severely injured patients and is frequently associated with prolonged mechanical ventilation, tracheostomy, and extended intensive care unit (ICU) treatment…
• Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma
  2026 · 脑科学 · Abstract Thoracic trauma is a major contributor to morbidity in severely injured patients and is frequently associated with prolonged mechanical ventilation, tracheostomy, and extended intensive care unit (ICU) treatment…
• Three-year retinal and visual outcomes after ultraviolet- and blue light-filtering intraocular lenses
  2026 · 脑科学 · Intraocular lens selection following cataract surgery has implications beyond refractive correction, with different lens chromophore compositions potentially affecting retinal light exposure and downstream visual and cir…
• Three-year retinal and visual outcomes after ultraviolet- and blue light-filtering intraocular lenses
  2026 · 脑科学 · Intraocular lens selection following cataract surgery has implications beyond refractive correction, with different lens chromophore compositions potentially affecting retinal light exposure and downstream visual and cir…
• Clinical-pathological diagnostic concordance in inflammatory dermatoses: a single-center retrospective analysis
  2026 · 脑科学 · Inflammatory dermatoses are a heterogeneous group with overlapping clinical presentations, often requiring histopathological confirmation. The concordance between clinical impression and pathological diagnosis remains un…
• Clinical-pathological diagnostic concordance in inflammatory dermatoses: a single-center retrospective analysis
  2026 · 脑科学 · Inflammatory dermatoses are a heterogeneous group with overlapping clinical presentations, often requiring histopathological confirmation. The concordance between clinical impression and pathological diagnosis remains un…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• Widening participation in cognitive neuroscience: a mixed-methods study of age-related motivators, barriers and attitudes towards imaging methods
  2026 · 脑科学 · Abstract Background Cognitive neuroscience research often relies on convenience sampling of participants, which can result in biased sample demographics and an under-representation of older adults. There is a need to ide…
• Widening participation in cognitive neuroscience: a mixed-methods study of age-related motivators, barriers and attitudes towards imaging methods
  2026 · 脑科学 · Abstract Background Cognitive neuroscience research often relies on convenience sampling of participants, which can result in biased sample demographics and an under-representation of older adults. There is a need to ide…
• Mycoplasma hyopneumoniae modulates ciliary function and epithelial integrity in air-liquid interface porcine respiratory epithelial cells (ALI-PRECs)
  2026 · 碳中和与 CCUS · ABSTRACT Mycoplasma hyopneumoniae ( Mhp ), the causative agent of enzootic pneumonia, disrupts mucociliary clearance by adhering to porcine ciliated airway cells, contributing to chronic respiratory disease. Traditional …
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• Harnessing genomic and bioinformatics for surveillance of pathogens in Africa: a scoping review of existing training and gaps in training
  2026 · 基因技术工具 · Abstract Background Pathogen surveillance is vital for managing infectious diseases in Africa, where high disease burdens necessitate advanced tools like genomics and bioinformatics. While these technologies enable early…
• Harnessing genomic and bioinformatics for surveillance of pathogens in Africa: a scoping review of existing training and gaps in training
  2026 · 基因技术工具 · Abstract Background Pathogen surveillance is vital for managing infectious diseases in Africa, where high disease burdens necessitate advanced tools like genomics and bioinformatics. While these technologies enable early…
• Mechanistic insights into the anticancer effects of apigenin in ovarian cancer: A systematic review
  2026 · 生命科学 · Ovarian cancer remains a leading cause of death among gynecological malignancies, characterized by high mortality rates and significant resistance to conventional treatments. Natural compounds, such as apigenin, a plant-…
• Mechanistic insights into the anticancer effects of apigenin in ovarian cancer: A systematic review
  2026 · 生命科学 · Ovarian cancer remains a leading cause of death among gynecological malignancies, characterized by high mortality rates and significant resistance to conventional treatments. Natural compounds, such as apigenin, a plant-…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Multimodal phenotypic clustering predicts cardiac outcomes in Fabry disease
  2026 · 生命科学 · Abstract Background Fabry disease (FD) is a rare lysosomal storage disorder with cardiac involvement. The efficacy of cardiac assessments in predicting disease progression is uncertain and few long-term studies have eval…
• Multimodal phenotypic clustering predicts cardiac outcomes in Fabry disease
  2026 · 生命科学 · Abstract Background Fabry disease (FD) is a rare lysosomal storage disorder with cardiac involvement. The efficacy of cardiac assessments in predicting disease progression is uncertain and few long-term studies have eval…
• From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis
  2026 · 中医药工具 · Abstract Background The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, an…
• From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis
  2026 · 中医药工具 · Abstract Background The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, an…
• From classical Chinese formula to modern mechanism: how Xiao-Yao-San modulates key signaling pathways in depression
  2026 · 中医药工具 · Abstract Depression is a widespread mental disorder with profound effects on both physical and psychological health. Aberrant signal transduction contributes to depression by impairing neuronal function, reducing synapti…
• From classical Chinese formula to modern mechanism: how Xiao-Yao-San modulates key signaling pathways in depression
  2026 · 中医药工具 · Abstract Depression is a widespread mental disorder with profound effects on both physical and psychological health. Aberrant signal transduction contributes to depression by impairing neuronal function, reducing synapti…
• Drying kinetics and metabolite dynamics of rhubarb during shade drying
  2026 · 中医药工具 · Rhubarb, valued in traditional Chinese medicine for both medicinal and edible uses, requires effective postharvest drying. Shade drying’s impact on its metabolic profile remains insufficiently studied. Fresh three-year-o…
• Drying kinetics and metabolite dynamics of rhubarb during shade drying
  2026 · 中医药工具 · Rhubarb, valued in traditional Chinese medicine for both medicinal and edible uses, requires effective postharvest drying. Shade drying’s impact on its metabolic profile remains insufficiently studied. Fresh three-year-o…
• Rewiring the cardiovascular epigenome: the multi-target strategy of traditional Chinese medicine
  2026 · 中医药工具 · Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), are fundamentally involved in the initiation and progression of cardiovascular diseases (CVDs). An increasing body of…
• Rewiring the cardiovascular epigenome: the multi-target strategy of traditional Chinese medicine
  2026 · 中医药工具 · Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), are fundamentally involved in the initiation and progression of cardiovascular diseases (CVDs). An increasing body of…
• Artificial intelligence in breast cancer: clinical applications in diagnosis, prognosis, and therapeutics
  2025 · 医疗人工智能 · Breast cancer (BC) presents a considerable global health challenge and is characterized by increasing mortality and morbidity rates. Prompt screening and accurate diagnosis are crucial for improving patient outcomes. For…
• Artificial intelligence in breast cancer: clinical applications in diagnosis, prognosis, and therapeutics
  2025 · 医疗人工智能 · Breast cancer (BC) presents a considerable global health challenge and is characterized by increasing mortality and morbidity rates. Prompt screening and accurate diagnosis are crucial for improving patient outcomes. For…
• Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease
  2025 · 脑科学 · This article conducts a systematic search of literature in the fields of neuroscience, cell biology, immunometabolism, etc. from 1990 to 2025, with PubMed/WebofScience as the core database. Experimental and clinical stud…
• 2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
  2025 · 脑科学 · Valosin-containing protein (VCP/p97) is a ubiquitously expressed AAA+ ATPase associated with numerous protein-protein interactions and critical cellular functions including protein degradation and clearance, mitochondria…
• Targeted Degradation Technologies Utilizing Autophagy
  2025 · 碳中和与 CCUS · Targeted degradation technologies, primarily referring to targeted protein degradation, have emerged as promising drug discovery strategies. In contrast to traditional "occupancy-driven" inhibition approaches, these tech…
• Wheels turning: CHO cell modeling moves into a digital biomanufacturing era
  2025 · 数字孪生 · Recent advancements in biologics production using CHO cells have been partly driven by improved understanding of how variations in the cell culture environment influence cellular metabolism, productivity, and the attribu…
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Data from: Regulation of the formin INF2 by actin monomers and calcium-calmodulin
  2025 · 核能 · In response to increased intracellular calcium, the formin INF2 polymerizes 20-30% of the total cellular actin pool within 30 sec, suggesting robust regulation. INF2 regulation requires an auto-inhibitory interaction bet…
• Ca2+-dependent cytoplasmic and nuclear phosphorylation of STOP1 by CPK21 and CPK23 confers ALMT1-dependent aluminum resistance
  2025 · 核能 · Calcium (Ca) signalling is critical for plant responses to aluminum (Al) stress, with STOP1-mediated ALMT1 expression playing a crucial role in Arabidopsis Al resistance. However, the specific intracellular Ca2+ sensors …
• A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells
  2025 · 合成生物与生物制造 · Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated in cancer, but EV heterogeneity a…
• Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
  2025 · 合成生物与生物制造 · Blood transfusion plays a vital role in modern medicine, but frequent shortages occur. Ex vivo manufacturing of red blood cells (RBCs) from universal donor cells offers a potential solution, yet the high cost of recombin…
• Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013
  2025 · 中医药工具 · Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement o…
• Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013
  2025 · 中医药工具 · Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement o…
• Chromatography-guided purification and characterization of <i>p-</i>hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo
  2025 · 中医药工具 · Melanogenesis is tightly regulated by tyrosinase, and its inhibition represents a key strategy in developing skin-whitening agents. In this study, p -hydroxyphenethyl anisate (HP) was identified as a potent melanogenesis…
• Chromatography-guided purification and characterization of <i>p-</i>hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo
  2025 · 中医药工具 · Melanogenesis is tightly regulated by tyrosinase, and its inhibition represents a key strategy in developing skin-whitening agents. In this study, p -hydroxyphenethyl anisate (HP) was identified as a potent melanogenesis…
• The multifaceted role of mitochondria in autism spectrum disorder
  2024 · 脑科学 · Abstract Normal brain functioning relies on high aerobic energy production provided by mitochondria. Failure to supply a sufficient amount of energy, seen in different brain disorders, including autism spectrum disorder …
• SURF2 is a MDM2 antagonist in triggering the nucleolar stress response
  2024 · 碳中和与 CCUS · Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as "nucleolar stress" (NS), triggering p53-dependent and indep…
• Deoxynivalenol induces m6A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro
  2024 · 碳中和与 CCUS · Abstract Hippocampal neurons maintain the ability of proliferation throughout life to support neurogenesis. Deoxynivalenol (DON) is a mycotoxin that exhibits brain toxicity, yet whether and how DON affects hippocampal ne…
• An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host
  2024 · 深海科技 · A limited number of bacteria are able to colonize the nuclei of eukaryotes. 'Candidatus Endonucleobacter' infects the nuclei of deep-sea mussels, where it replicates to ≥80,000 bacteria per nucleus and causes nuclei to s…
• An ultrathin membrane mediates tissue-specific morphogenesis and barrier function in a human kidney chip
  2024 · 数字孪生 · Organ-on-chip (OOC) systems are revolutionizing tissue engineering by providing dynamic models of tissue structure, organ-level function, and disease phenotypes using human cells. However, nonbiological components of OOC…
• Additional file 2 of Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable
  2024 · 基因技术工具 · Supplementary material 2 : Fig. S1 Additional characterisation of cultured neutrophils. A: Schematic outlining culture procedure (top) or acquisition of native neutrophils. Figure generated in Biorender. B: Representativ…
• Additional file 2 of Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable
  2024 · 基因技术工具 · Supplementary material 2 : Fig. S1 Additional characterisation of cultured neutrophils. A: Schematic outlining culture procedure (top) or acquisition of native neutrophils. Figure generated in Biorender. B: Representativ…
• Atg8 family proteins, LIR/AIM motifs and other interaction modes.
  2024 · 核能 · The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also…

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