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pharmacology

GeneTech 知识引擎共收录 5534 篇相关科研实体，横跨 30 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes
  2022 · AI Agent 生态 · , with the activities of anti-inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the present research, a triple-transgenic mice model of AD (3 × Tg-AD) was used to explore the beneficial a…
• The Role of Resveratrol in Cancer Therapy
  2017 · AI Agent 生态 · Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, inc…
• The Biofilm Plight in Healthcare: Orchestration and Control by Lactiplantibacillus plantarum.
  2026 · AI Agent 生态 · The clinical consequences of biofilm-related infections are on the rise. Biofilm-related infections represent a mounting burden on healthcare worldwide, posing a significant challenge to patient care and health infrastru…
• PLGA - encapsulated harmine derivative H-2-168: A promising therapeutic agent for mitigating liver damage in hepatic hydatid disease.
  2026 · AI Agent 生态 · Harmine (HM), a bioactive alkaloid, exhibits remarkable antiparasitic potency. Nevertheless, its translational potential is substantially constrained by neurotoxicity, necessitating the development of safer analogs. H-2-…
• Laboratory Toxicity and Field Efficacy of Four Microbial-Derived Pesticides Combined with Two Adjuvants Against <i>Lygus pratensis</i> (Hemiptera: Miridae).
  2026 · AI Agent 生态 · Systematic field data on adjuvant-amended microbial-derived pesticides against L. pratensis in arid, high-ultraviolet cotton regions remain scarce. This study systematically evaluated the laboratory toxicity and field ef…
• Total Flavonoids from <i>Carthamus tinctorius</i> L. Reduce Liver Fibrosis by Influencing Autophagy via Hedgehog Signaling.
  2026 · AI Agent 生态 · Liver fibrosis is a critical determinant of the progression of chronic liver disease (CLD). Total flavonoids from Carthamus tinctorius L. (TFCTLs) exhibit diverse pharmacological activities while their effect on liver fi…
• The MID1IP1/S100A10-mGluR5 Axis in Seizures: Immune-Metabolic Crosstalk and Enhanced Therapeutic Efficacy of Benfotiamine/Phenytoin Combination.
  2026 · AI Agent 生态 · Introduction Epilepsy, characterized by recurrent seizures, is associated with dysregu-lated Fatty Acid (FA) metabolism and metabotropic glutamate receptor 5 (mGluR5) signaling. However, the contribution of FA metabolism…
• Research on the Highly Efficient and Low-Dose Improvement of Alcohol-Induced Liver Injury by High-Selenium-Content Modified Lycium barbarum Polysaccharides.
  2026 · AI Agent 生态 · There are currently no FDA-approved drugs for the treatment of alcohol-related liver diseases (ALD) due to their lack of effectiveness. Selenium-modified Lycium barbarum polysaccharides (SeLBP), as a promising agent for …
• PetroAgents: A Multi-Agent, Multi-Modal Large-Language-Model Framework for Integrated Upstream Petroleum Asset Reasoning, Benchmarked on the Equinor Volve Open Dataset
  2026 · AI Agent 生态 · We present PetroAgents, a multi-agent, multi-modal large-language-model framework for petroleum-engineering reasoning on the Equinor Volve open dataset. The target architecture mirrors an integrated asset team: disciplin…
• AI-driven discovery of bronopol for the treatment of pulmonary fibrosis via inhibition of fibroblast activation.
  2026 · AI Agent 生态 · Aims Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Epigenetic regulation by p300 histone acetyltransferase plays a central role in fibroblast activation and fi…
• Interleukin-38 promotes alveolar bone repair in periodontitis by suppressing the nuclear factor kappa B pathway.
  2026 · AI Agent 生态 · Background Periodontitis, characterized by chronic inflammation and alveolar bone loss, poses significant challenges to oral health. Interleukin-38 (IL-38) has emerged as a potential therapeutic agent due to its anti-inf…
• Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations.
  2026 · AI Agent 生态 · The landscape of drug delivery is undergoing a transformative shift. As demand for large-volume subcutaneous (SC) biologics continues to surge, the race to develop smarter, patient-centered combination drug products has …
• Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective.
  2026 · AI Agent 生态 · Cryopreservation is the storage of biological materials like cells, tissues, or even organs at cryogenic temperatures. This technology is a key enabler for biobanking, reproductive medicine, and cell therapy, and is posi…
• Lactate-sensitive nanomachines for enzyme-controlled drug delivery in cancer therapy.
  2026 · AI Agent 生态 · Here, we report the preparation of a novel enzyme-powered nanomachine for a drug delivery system based on mesoporous silica nanoparticles capped with a cyclodextrin-lactate oxidase (CD-LOx) complex, which enables control…
• Precision oncology in the age of AI: lessons from AI-driven drug discovery and clinical translation.
  2026 · AI Agent 生态 · Drug discovery has been constrained by extended timelines and high costs, as the cumulative requirements of preclinical validation, multi-phase clinical trials, and regulatory approval have been imposed. Recently, comput…
• Navigating the Evolution of Urothelial Carcinoma Treatment: From Chemotherapy to Immunotherapy.
  2026 · AI Agent 生态 · Background The urothelial carcinoma (UC) trial landscape has expanded over two decades, alongside a shift from chemotherapy to immunotherapy and targeted approaches. We characterized temporal patterns in trial phase, int…
• Probiotics: multifunctional microorganisms for human health and biotechnological applications.
  2026 · AI Agent 生态 · Probiotics are live microorganisms that, when ingested in sufficient amounts, can have a beneficial impact on health. As crucial agents in maintaining gut homeostasis, enhancing immunity, and preventing of numerous disea…
• Simultaneous Determination of Total and Unbound Amphotericin B by LC-MS/MS: Application to Protein Binding Analysis.
  2026 · AI Agent 生态 · Amphotericin B (AmB), a first-line antifungal agent, is highly protein-bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on …
• BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering
  2026 · AI Agent 生态 · ABSTRACT Clinical studies of chimeric antigen receptor (CAR)-T therapy generate diverse molecular and clinical evidence that remains fragmented across publications, public repositories and patient-derived datasets, limit…
• Shrimp Aquaculture Under Viral Threats: Insights into Pathogens and Control Strategies.
  2026 · AI Agent 生态 · Viral diseases are among the most serious threats to shrimp aquaculture, causing large-scale mortality and production losses. This review summarizes current knowledge on the major viral diseases affecting cultured penaei…
• MS4MS: LLMs-driven Multi-agent System for Small-molecule Identification via LC-MS/MS
  2025 · AI Agent 生态 · Small molecule identification is central to research fields such as drug discovery, but in complex systems like Traditional Chinese Medicine (TCM), traditional mass spectrometry analysis methods remain constrained by bot…
• Multi-isolate GWAS identifies broad-spectrum and isolate-specific Septoria tritici blotch resistance loci in synthetic hexaploid wheat
  2026 · AI Agent 生态 · Abstract Septoria tritici blotch (STB), caused by Zymoseptoria tritici , remains a major constraint on wheat production worldwide. Erosion of host resistance and declining fungicide efficacy highlight the need to exploit…
• A dynamic pharmacometric framework defining the relationship between ivermectin exposure and mosquito lethality
  2026 · AI Agent 生态 · Abstract Ivermectin is used in the treatment of several neglected tropical diseases. Studies have shown that it effectively kills anopheline mosquitoes. However, the relationship between the pharmacokinetic properties an…
• Four Decades of Genomic Stability and Adaptive Divergence in <i>Xanthomonas arboricola</i> pv. <i>pruni</i> -Infecting Phages: Defining <i>Duraznoxanthovirus arenicola</i> and Its Evolutionary Framework
  2025 · AI Agent 生态 · Bacteriophages (phages) are abundant and ecologically significant, yet their diversity and roles in plant-associated ecosystems remain poorly understood, limiting their application in sustainable disease management. To a…
• Discovery of a radiation countermeasure therapeutic for intestinal injury enabled by human organ chips combined with AI
  2025 · AI Agent 生态 · There is a need for better therapies for acute radiation injury (ARI) of the human intestine as current treatments offer limited efficacy. As the ileum is most sensitive to radiation in patients receiving cancer radiatio…
• AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
  2025 · AI Agent 生态 · Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a…
• Adverse Events Associated with Busulfan in HSCT Pre-Transplant Conditioning: A Retrospective Pharmacovigilance Study of the FAERS Database
  2025 · AI Agent 生态 · Abstract Background: Busulfan had been approved as a pre-transplant conditioning agent for allogeneic hematopoietic stem cell transplantation (HSCT) in chronic myeloid leukemia. However, the real-world data on its safety…
• <i>M. tuberculosis</i> meets European Lead Factory – identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
  2025 · AI Agent 生态 · Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. Proteins involved in lipid metabolism, such as the monoacylglycerol lipase Rv0183, play critical roles during both…
• A Review of Multimodal Treatment Approach in Hypertrophic Cardiomyopathy
  2025 · AI Agent 生态 · Hypertrophic cardiomyopathy (HCM) is often associated with left ventricular outflow tract (LVOT) obstruction, which affects a substantial proportion of patients. This obstruction results from a range of anatomical abnorm…
• Luteolin as a urease inhibitor: A novel therapeutic strategy against Helicobacter pylori.
  2026 · AI Agent 生态 · The rising prevalence of antibiotic-resistant Helicobacter pylori ( H. pylori ) underscores the urgent need for alternative treatment strategies. By producing ammonia to neutralize gastric acid, the key virulence factor …
• Antibacterial and Wound-Healing Efficacy of 12-Hydroxylauric Acid-Conjugated Heterochiral Diphenylalanines: Insights From In Vitro and In Vivo Investigations.
  2026 · AI Agent 生态 · To overcome the limitations of microbial infections in modern medicine, we developed compound I incorporating the amphiphile 12-hydroxy lauric acid (12-HDA) at the N-terminus linked to a heterochiral diphenylalanine moti…
• Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review.
  2026 · AI Agent 生态 · Kaempferol (KAE), a natural flavonoid, has emerged as a promising multi-target antineoplastic agent characterized by high efficacy and minimal systemic toxicity. Moving beyond fragmented descriptive summaries, this compr…
• Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence.
  2026 · AI Agent 生态 · Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment effi…
• The role of ginsenosides in obesity-associated sarcopenia: Focus on E3 ubiquitin ligase-mediated regulation of protein homeostasis.
  2026 · AI Agent 生态 · Obesity-associated sarcopenia (OAS) is a complex metabolic disorder characterized by excessive adiposity accompanied by progressive skeletal muscle loss, largely driven by impaired protein homeostasis. The ubiquitin-prot…
• Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases.
  2026 · AI Agent 生态 · Once regarded solely as an intermediate of the tricarboxylic acid (TCA) cycle involved in energy production, fumarate has now emerged as a pivotal immunometabolite with far-reaching effects on inflammatory signaling and …
• Hierarchically Micro-Nano Porous Electrospun PBLG Mineralized Scaffolds: A Biomimetic Triune Platform Orchestrating Angio-Osteogenic Activation and Osteoclastogenic Inhibition.
  2026 · AI Agent 生态 · The natural bone matrix is a heterogeneous three-dimensional mineralized fiber network structure composed of inorganic components (mainly hydroxyapatite) and organic components (collagen-&#x406;), endowing natural bone w…
• From exhaustion to functional cure: frontiers in reversing HBV-specific T-cell immunity.
  2026 · AI Agent 生态 · Chronic hepatitis B (CHB) remains a leading cause of liver-related morbidity and mortality, affecting approximately 254 million people worldwide and accounting for more than 800,000 deaths annually. Although nucleos(t)id…
• Cancer-Associated Fibroblast Heterogeneity and Extracellular Matrix Remodeling as Orchestrators of Drug Resistance in Upper Gastrointestinal Cancers: Insights from Spatial Multi-Omics and Therapeutic Implications.
  2026 · AI Agent 生态 · Upper gastrointestinal (GI) cancers, including esophageal, gastric, and pancreatic cancers, remain among the most lethal malignancies worldwide, mainly because they resist nearly every therapeutic modality, from platinum…
• Mitochondrial and Epigenetic Drivers of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease.
  2026 · AI Agent 生态 · Skeletal muscle dysfunction (SMD) is a critical extrapulmonary comorbidity in chronic obstructive pulmonary disease (COPD), contributing to exercise intolerance, poor quality of life, and increased mortality. Building up…
• Redox-regulated cell death in gastric cancer: Molecular insights and therapeutic opportunities.
  2026 · AI Agent 生态 · Oxidative stress, resulting from the disruption of redox homeostasis, is increasingly recognized as a central driver of gastric cancer pathogenesis and a critical determinant of cell fate. An imbalance between reactive o…
• Autophagy as a multi-scale architect of fungal development and pathogenicity: membrane dynamics, multilayer regulation, and cell wall integrity crosstalk.
  2026 · AI Agent 生态 · Autophagy is a conserved membrane-trafficking pathway traditionally viewed as a nonspecific nutrient recycling mechanism. However, recent advances across diverse fungal systems, from plant pathogens to human opportunisti…
• Reprogramming tumor angiogenesis in breast cancer: Mechanisms, challenges, and future directions.
  2026 · AI Agent 生态 · Angiogenesis serves as a central hallmark of breast cancer progression by driving the formation of a dysfunctional vascular network that sustains tumor growth, enables metabolic adaptation, and facilitates metastasis. Hy…
• Leveraging Kinesin Family as Key Regulators of Malignant Progression and the Immunometabolic Niche for Precision Oncology.
  2026 · AI Agent 生态 · Malignant tumors impose a substantial burden on global health, with an urgent unmet need for effective targets to advance precision therapy. As evolutionarily conserved microtubule motor proteins, the kinesin family (KIF…
• Copper-Catalyzed Cascades Enable Fused Pyrroles with Tunable Ring Sizes.
  2026 · AI Agent 生态 · A novel route for the preparation of fused pyrroles with tunable ring sizes is presented as a copper-catalyzed tandem [3+2] cyclization/Ullmann coupling. This protocol established a versatile and general platform for the…
• The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury.
  2026 · AI Agent 生态 · The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review advances the concept…
• Fisetin attenuates CCl₄-induced liver fibrosis through modulation of TGF-β1/Smad3 and p53/Bax/Bcl-2 signaling pathways.
  2026 · AI Agent 生态 · Liver fibrosis arises from a sustained imbalance between oxidative stress, cell death, and matrix deposition. Using the carbon tetrachloride (CCl 4 ) mouse model, we show that the dietary flavonoid, fisetin orchestrates …
• Ligand-resolved in vivo phosphoproteomics of the adult heart maps ErbB signaling by EGF and NRG1β.
  2026 · AI Agent 生态 · ErbB receptor tyrosine kinases orchestrate phosphorylation-based signaling in response to extracellular ligands and are key drivers in cancer biology. Although ErbB-targeted therapies have transformed cancer care, some a…
• Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.
  2026 · AI Agent 生态 · The tumor microenvironment is a critical regulator of cancer progression. Histone lactylation, a novel post-translational modification, has emerged as a key player in various tumors and is closely linked to macrophage po…
• Pathology-Targeted Nanoparticles Guided by Peptide Remodel the Periodontal Microenvironment for Periodontitis Therapy.
  2026 · AI Agent 生态 · Periodontitis is an inflammatory and destructive condition, conventional therapies yield inadequate long-term efficacy and possess limited regenerative potential, while the diseased microenvironment driven by inflammatio…
• Post-transcriptional regulation in cancer chemoresistance.
  2026 · AI Agent 生态 · Cancer remains the second leading cause of death worldwide, surpassed only by cardiovascular diseases. Although cancer-specific mortality rates have declined due to advances in early detection and therapeutic strategies,…
• CDK4/6-targeted therapy: From clinical inhibitors to emerging strategies to overcome resistance.
  2026 · AI Agent 生态 · The Cyclin-dependent kinase 4/6 (CDK4/6) complex orchestrates the critical G1-to-S phase transition by phosphorylating the Retinoblastoma protein (Rb), establishing it as a validated therapeutic target in oncology. The c…
• Recombinant bone morphogenetic protein-2 attenuates colorectal cancer progression by orchestrating Hippo pathway activation, Yes-associated protein inhibition, and epithelial-mesenchymal transition suppression.
  2026 · AI Agent 生态 · Bone morphogenetic protein-2 (BMP-2) regulates cell differentiation and proliferation. However, its role in colorectal cancer (CRC) remains debatable owing to potential oncogenic effects. Here, we investigated the role o…
• DNA origami as a biomaterials platform for programming ligand-receptor interactions and cell fate.
  2026 · AI Agent 生态 · DNA origami has emerged as a versatile biomaterials platform enabling programmable control over the nanoscale spatial organization of ligands. Unlike conventional biomaterials platforms, which offer limited geometric pre…
• Molecular Effects of Parkia speciosa Hassk. Empty Pod Extract in Colon Cancer: A Transcriptomic and Proteomic Perspective.
  2026 · AI Agent 生态 · This study elucidates the multi-targeted antineoplastic mechanisms of Parkia speciosa empty pod extract (PSET) against HCT-116 and HT-29 colorectal cancer (CRC) cells through integrated transcriptomic and proteomic analy…
• Orchestrating Diabetic Wound Healing by a Sunlight-Activated AIEgen-Selenide Nanospray: From Infection Control to Tissue Regeneration.
  2026 · AI Agent 生态 · Diabetic wounds, particularly diabetic ulcers (DUs), are life-threatening complications driven by bacterial infection, persistent inflammation, oxidative stress, and a dysfunctional immune microenvironment. Addressing th…
• New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.
  2026 · AI Agent 生态 · Macrophages are plastic innate immune cells that polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes in response to microenvironmental signals, with their dynamic balance governing inflammation resolutio…
• Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF.
  2026 · AI Agent 生态 · Tyrosinase is a pivotal therapeutic target for hyperpigmentation disorders, yet current inhibitors frequently exhibit limited potency and suboptimal safety. Here, we employed structure-based virtual screening of an FDA-a…
• Transcriptomic insights into the biocontrol mechanism of Trichoderma spp. against Fusarium wilt in melon.
  2026 · AI Agent 生态 · Fusarium wilt (FW), caused by Fusarium oxysporum f. sp. melonis (FOM), is a devastating disease severely impacting global melon (Cucumis melo L.) production. Biocontrol agents such as Trichoderma species, offer a sustain…
• Beyond resorption: targeting osteoclast fusion and polarization to restore balanced bone remodeling.
  2026 · AI Agent 生态 · The prevalence of osteoporosis is increasing worldwide as populations age, creating a growing clinical burden of fragility fractures and highlighting limitations of current antiresorptive therapies. Conventional agents s…
• Insights in Food Allergy from DCs: The Influence and Mechanism of Diet Components with Antiallergic Properties.
  2026 · AI Agent 生态 · Food allergy (FA), defined as abnormal immunological response to certain food proteins, is a serious issue in food safety and public health. Dendritic cells (DCs) orchestrate tolerance or allergic reactions to food prote…

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