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genetics

GeneTech 知识引擎共收录 279 篇相关科研实体，横跨 18 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• A visual transformer and multi-task learning framework for building generalisation from raster maps
  2026 · 脑科学 · Building generalisation transforms detailed large-scale building representations into suitable simplified forms for smaller-scale urban topographic maps. Existing deep learning-based approaches for raster building maps a…
• A visual transformer and multi-task learning framework for building generalisation from raster maps
  2026 · 脑科学 · Building generalisation transforms detailed large-scale building representations into suitable simplified forms for smaller-scale urban topographic maps. Existing deep learning-based approaches for raster building maps a…
• Statewide surficial geologic map of Nebraska underscores Quaternary landscape evolution from the High Plains to the Central Lowland
  2026 · 脑科学 · Surficial geologic mapping in Nebraska has been conducted primarily at the 1:24,000 scale since the mid-1990s, although there have also been limited efforts to map generalized Quaternary and surficial geology within the …
• Statewide surficial geologic map of Nebraska underscores Quaternary landscape evolution from the High Plains to the Central Lowland
  2026 · 脑科学 · Surficial geologic mapping in Nebraska has been conducted primarily at the 1:24,000 scale since the mid-1990s, although there have also been limited efforts to map generalized Quaternary and surficial geology within the …
• A pantothenic acid deficiency outbreak causing mortality and neuromuscular disorders in newborn and nursery piglets
  2026 · 脑科学 · Abstract Background The present case report describes the clinical and pathological outcomes of an outbreak of piglet mortality and neuromuscular disorders in newborn and nursery piglets caused by vitamin B5 deficiency. …
• A pantothenic acid deficiency outbreak causing mortality and neuromuscular disorders in newborn and nursery piglets
  2026 · 脑科学 · Abstract Background The present case report describes the clinical and pathological outcomes of an outbreak of piglet mortality and neuromuscular disorders in newborn and nursery piglets caused by vitamin B5 deficiency. …
• Psychiatric manifestations in Neuronal ceroid lipofuscinoses
  2026 · 脑科学 · Abstract Background Neuronal ceroid lipofuscinoses (NCLs) are rare genetic neurodegenerative disorders characterized by progressive cognitive, motor, and visual decline. The transition from supportive care to emerging di…
• Psychiatric manifestations in Neuronal ceroid lipofuscinoses
  2026 · 脑科学 · Abstract Background Neuronal ceroid lipofuscinoses (NCLs) are rare genetic neurodegenerative disorders characterized by progressive cognitive, motor, and visual decline. The transition from supportive care to emerging di…
• Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma
  2026 · 脑科学 · Abstract Thoracic trauma is a major contributor to morbidity in severely injured patients and is frequently associated with prolonged mechanical ventilation, tracheostomy, and extended intensive care unit (ICU) treatment…
• Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma
  2026 · 脑科学 · Abstract Thoracic trauma is a major contributor to morbidity in severely injured patients and is frequently associated with prolonged mechanical ventilation, tracheostomy, and extended intensive care unit (ICU) treatment…
• Integrating machine learning and statistical design for sustainable Fenton catalysis: enhancing dye degradation in wastewater treatment
  2026 · 脑科学 · The use of computer modeling in the Fenton process holds considerable promise for enhancing process efficiency and sustainability. Although considerable study has been conducted on the traditional Fenton process, investi…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• Channeling Multimodality Through a Unimodalizing Transport: Warp-U Sampler and Stochastic Bridge Sampling Estimator
  2026 · 地外科学 · Monte Carlo integration is a powerful tool for scientific and statistical computation, but faces significant challenges when multi-modal distributions are involved, even when the mode locations are known. This work intro…
• Channeling Multimodality Through a Unimodalizing Transport: Warp-U Sampler and Stochastic Bridge Sampling Estimator
  2026 · 地外科学 · Monte Carlo integration is a powerful tool for scientific and statistical computation, but faces significant challenges when multi-modal distributions are involved, even when the mode locations are known. This work intro…
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• Supplementary materials for chapter 2: PMR4 is a susceptibility gene for soft rot disease in potato
  2026 · 基因技术工具 · This dataset contains the supplementary materials associated with Chapter 2 of Pichaya T. Cheewapoonphon's PhD thesis, including the data and results from RNA-sequencing analysis (RNA quantity, Differential Gene Expressi…
• Supplementary materials for chapter 2: PMR4 is a susceptibility gene for soft rot disease in potato
  2026 · 基因技术工具 · This dataset contains the supplementary materials associated with Chapter 2 of Pichaya T. Cheewapoonphon's PhD thesis, including the data and results from RNA-sequencing analysis (RNA quantity, Differential Gene Expressi…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Multimodal phenotypic clustering predicts cardiac outcomes in Fabry disease
  2026 · 生命科学 · Abstract Background Fabry disease (FD) is a rare lysosomal storage disorder with cardiac involvement. The efficacy of cardiac assessments in predicting disease progression is uncertain and few long-term studies have eval…
• Multimodal phenotypic clustering predicts cardiac outcomes in Fabry disease
  2026 · 生命科学 · Abstract Background Fabry disease (FD) is a rare lysosomal storage disorder with cardiac involvement. The efficacy of cardiac assessments in predicting disease progression is uncertain and few long-term studies have eval…
• Evaluating AR glasses for driving assistance: a comparative case study against an AR-HUD in simulated driving with navigation and infotainment conditions
  2026 · 空间计算 · The ongoing advancement of technology has established Augmented Reality (AR) as a significant component of in-vehicle assistance systems. AR glasses, an emerging form of AR device, can present information within the driv…
• Evaluating AR glasses for driving assistance: a comparative case study against an AR-HUD in simulated driving with navigation and infotainment conditions
  2026 · 空间计算 · The ongoing advancement of technology has established Augmented Reality (AR) as a significant component of in-vehicle assistance systems. AR glasses, an emerging form of AR device, can present information within the driv…
• Data underlying the publication: Image-based phenotypic sorting of synthetic cells
  2026 · 合成生物与生物制造 · Data underlying the publication: Van den Brink, M., Stam, M., Claassens, N.J. and Danelon, C. (2026) Image-based phenotypic sorting of synthetic cells. Sci. Adv. 12, eaed0860. DOI: 10.1126/sciadv.aed0860. This dataset co…
• Data underlying the publication: Image-based phenotypic sorting of synthetic cells
  2026 · 合成生物与生物制造 · Data underlying the publication: Van den Brink, M., Stam, M., Claassens, N.J. and Danelon, C. (2026) Image-based phenotypic sorting of synthetic cells. Sci. Adv. 12, eaed0860. DOI: 10.1126/sciadv.aed0860. This dataset co…
• Data underlying PhD thesis chapter: Co-optimization of the genetic and molecular compositions of a synthetic cell
  2026 · 合成生物与生物制造 · Data underlying Chapter 5 of the PhD thesis of Marijn van den Brink with the title: "Laboratory evolution of synthetic cells". This dataset contains data collected during experiments as part of Marijn van den Brink's PhD…
• Data underlying PhD thesis chapter: Co-optimization of the genetic and molecular compositions of a synthetic cell
  2026 · 合成生物与生物制造 · Data underlying Chapter 5 of the PhD thesis of Marijn van den Brink with the title: "Laboratory evolution of synthetic cells". This dataset contains data collected during experiments as part of Marijn van den Brink's PhD…
• Data underlying the publication: Combinatorial optimization of protein systems in synthetic cells
  2026 · 合成生物与生物制造 · Data underlying the publication: van den Brink, M., Claassens, N.J. and Danelon, C. Combinatorial optimization of protein systems in synthetic cells. ACS Synthetic Biology (2026). https://doi.org/10.1021/acssynbio.6c0016…
• Data underlying the publication: Combinatorial optimization of protein systems in synthetic cells
  2026 · 合成生物与生物制造 · Data underlying the publication: van den Brink, M., Claassens, N.J. and Danelon, C. Combinatorial optimization of protein systems in synthetic cells. ACS Synthetic Biology (2026). https://doi.org/10.1021/acssynbio.6c0016…
• Data underlying the publication: Combinatorial optimization of protein systems in synthetic cells
  2026 · 合成生物与生物制造 · Data underlying the publication: van den Brink, M., Claassens, N.J. and Danelon, C. Combinatorial optimization of protein systems in synthetic cells. ACS Synthetic Biology (2026). https://doi.org/10.1021/acssynbio.6c0016…
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  2026 · 合成生物与生物制造 · Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable…
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  2026 · 合成生物与生物制造 · Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable…
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  2026 · 合成生物与生物制造 · Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-produc…
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  2026 · 合成生物与生物制造 · Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-produc…
• Methanol-based biosynthesis of p-coumaric acid by engineered Pichia pastoris
  2026 · 合成生物与生物制造 · Abstract p-Coumaric acid (p-CA) is a key aromatic precursor for the biosynthesis of flavonoids, stilbenoids, and other high-value phenylpropanoids. While microbial production of p-CA typically relies on sugar-based subst…
• Beyond antitumor activity and from lichenized fungi: advances in the production, bioactivities, synthesis, and biosynthesis of usnic acid and its structural derivatives
  2026 · 合成生物与生物制造 · Usnic acid and its structural derivatives are dibenzofuran natural products characterized by a distinctive 6-5-6 tricyclic scaffold. These compounds, isolated from lichenized fungi, non-lichenized fungi, and select highe…
• Beyond antitumor activity and from lichenized fungi: advances in the production, bioactivities, synthesis, and biosynthesis of usnic acid and its structural derivatives
  2026 · 合成生物与生物制造 · Usnic acid and its structural derivatives are dibenzofuran natural products characterized by a distinctive 6-5-6 tricyclic scaffold. These compounds, isolated from lichenized fungi, non-lichenized fungi, and select highe…
• A superfamily of bioactive proteins from fungi - are these secondary metabolites?
  2026 · 合成生物与生物制造 · Abstract Background Since decades, fungi are leveraged in biotechnology to produce high-value compounds used in multiple economic sectors. Strain and process optimisation is based on a comprehensive understanding of the …
• A superfamily of bioactive proteins from fungi - are these secondary metabolites?
  2026 · 合成生物与生物制造 · Abstract Background Since decades, fungi are leveraged in biotechnology to produce high-value compounds used in multiple economic sectors. Strain and process optimisation is based on a comprehensive understanding of the …
• Metagenomic analysis of intestinal microbiota characteristic differences between patients with ankylosing spondylitis and healthy individuals
  2026 · 中医药工具 · Abstract Background To explore the differences in intestinal microbiota between patients with ankylosing spondylitis (AS) and healthy individuals (HC) in terms of genetic, species composition, and functional levels, and …
• Metagenomic analysis of intestinal microbiota characteristic differences between patients with ankylosing spondylitis and healthy individuals
  2026 · 中医药工具 · Abstract Background To explore the differences in intestinal microbiota between patients with ankylosing spondylitis (AS) and healthy individuals (HC) in terms of genetic, species composition, and functional levels, and …
• From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis
  2026 · 中医药工具 · Abstract Background The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, an…
• From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis
  2026 · 中医药工具 · Abstract Background The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, an…
• Ferroptosis: significance to zoonotic diseases and therapeutic prospects
  2026 · 中医药工具 · Ferroptosis is a distinct modality of programmed cell death driven by iron-dependent lipid peroxidation, exerting a pivotal regulatory influence on the infection dynamics and immune responses associated with zoonoses. Th…
• Ferroptosis: significance to zoonotic diseases and therapeutic prospects
  2026 · 中医药工具 · Ferroptosis is a distinct modality of programmed cell death driven by iron-dependent lipid peroxidation, exerting a pivotal regulatory influence on the infection dynamics and immune responses associated with zoonoses. Th…
• Rewiring the cardiovascular epigenome: the multi-target strategy of traditional Chinese medicine
  2026 · 中医药工具 · Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), are fundamentally involved in the initiation and progression of cardiovascular diseases (CVDs). An increasing body of…
• Rewiring the cardiovascular epigenome: the multi-target strategy of traditional Chinese medicine
  2026 · 中医药工具 · Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), are fundamentally involved in the initiation and progression of cardiovascular diseases (CVDs). An increasing body of…
• Computational insights into mercuric reductase from <i>Pseudomonas fluorescens</i>: a bioinformatic and molecular dynamics approach for mercury detoxification
  2025 · AI 驱动科学发现 · Mercury (Hg) pollution poses significant threats to human health and ecosystems worldwide due to its persistence, bioaccumulation, and toxic effects. This study focuses on mercuric reductase from Pseudomonas fluorescens …
• The China National GeneBank Sequence Archive (CNSA) 2024 update
  2025 · 生物计算 · The China National GeneBank Sequence Archive (CNSA) is an open and freely accessible curated data repository built for archiving, sharing, and reutilizing of multiomics data. The remarkable advancement in sequencing tech…
• Perspectives on the Current and Future State of Artificial Intelligence in Medical Genetics
  2025 · 医疗人工智能 · Artificial intelligence (AI) is rapidly transforming numerous aspects of daily life, including clinical practice and biomedical research. In light of this rapid transformation, and in the context of medical genetics, we …
• An audit of AI-related documents across U.S. medical schools: A framework-based qualitative content analysis
  2025 · 医疗人工智能 · Medical schools would benefit from systematic guidance for developing comprehensive artificial intelligence (AI) policies, given generative AI’s rapid integration into medical education. This study developed and applied …
• An audit of AI-related documents across U.S. medical schools: A framework-based qualitative content analysis
  2025 · 医疗人工智能 · Medical schools would benefit from systematic guidance for developing comprehensive artificial intelligence (AI) policies, given generative AI’s rapid integration into medical education. This study developed and applied …
• Cancer cell dormancy: An update to 2025
  2025 · 脑科学 · About 70 years ago, scientists first observed groups of cancer cells in a “temporary mitotic arrest,” a dormant state that complicates treatment and increases the risk of recurrence. Recent updates have provided novel in…
• Mapping VEXAS ‐associated and rare UBA1 variants in the United Kingdom : Insights from patient cohorts and the general population
  2025 · 碳中和与 CCUS · Somatic mutations in UBA1 are linked to VEXAS syndrome, a late-onset inflammatory disorder with rheumatological and haematological features, primarily affecting elderly men. This study examines the epidemiology of VEXAS …
• Distinct characteristics of VEXAS-causative UBA1 M41 and recurrent functional non-M41 mutations
  2025 · 碳中和与 CCUS · VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a severe inflammatory and hematologic disease caused by somatic mutations in UBA1. Canonical pathogenic mutations at UBA1 p.Met41 (M41) lead to…
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Reinvigorating AMR resilience: leveraging CRISPR–Cas technology potentials to combat the 2024 WHO bacterial priority pathogens for enhanced global health security—a systematic review
  2025 · 基因技术工具 · Abstract Background Antimicrobial resistance (AMR) poses a global health threat, particularly in low- and middle-income countries (LMICs). Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas system tec…

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