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GeneTech 知识引擎共收录 2993 篇相关科研实体，横跨 30 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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代表性文献（按质量分排序，前 60 条）

• Genome-Wide Characterization of the <i>Botryosphaeria dothidea</i> GH28 Family Reveals BdGH28_3 Contributes to Virulence on Chinese Hickory.
  2026 · AI 驱动科学发现 · Chinese hickory ( Carya cathayensis Sarg.) is an economically important tree species widely cultivated in southeastern China, where trunk canker disease caused by Botryosphaeria dothidea poses a serious threat to tree he…
• Establishment of an efficient and PAM-relaxed LbCas12a genome editing tool in plants.
  2026 · AI 驱动科学发现 · Cas12a is widely used in plant genome editing, but its targeting scope is constrained by stringent protospacer adjacent motif (PAM) requirements and variable activity across species, limiting its application at diverse g…
• Assessing particle application in multi-pass overlapping scenarios with variable rate centrifugal fertilizer spreaders for precision agriculture
  2025 · 智慧农业 · Environmental impacts and economic demands are driving the development of variable rate fertilization (VRF) technology for precision agriculture. Despite the advantages of a simple structure, low cost and high efficiency…
• Interpretable Machine Learning and Comparative Genomics Reveal Microbial Plastic-Degrading (Microbeyt) Potential
  2025 · AI 驱动科学发现 · Abstract Plastic pollution poses a critical environmental threat, and microbial enzymes represent a sustainable strategy for polymer degradation. We present a computational pipeline that integrates orthogroup-based genom…
• tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs
  2024 · AI 安全与对齐 · Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immunotherapies and vaccines. To elucidate the specificity of previously unseen…
• Chromosome alignment relies on spindle-localized control of Cdk1 activity
  2024 · AI 安全与对齐 · Abstract During mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells. A central role for chromosome alignment is exerted by the …
• Machine learning approaches for estimating cross-neutralization potential among FMD serotype O viruses
  2024 · AI 驱动科学发现 · Abstract In this study, we aimed to develop an algorithm that uses sequence data to estimate cross-neutralization between serotype O foot-and-mouth disease viruses (FMDV) based on r1 values, while identifying key genomic…
• Basic Local Alignment Search Tool (Blast) and Multiple Sequence Alignment
  2023 · AI 安全与对齐 · This chapter look at the topic of pairwise sequence comparison by describing the Basic Local Alignment Search Tool (BLAST). It discusses multiple sequence alignment programs with an emphasis on the first popular program …
• Současná role AI v historických vědách a výzkumu
  2026 · AI 驱动科学发现 · Umělá inteligence (AI) jakožto software pro generování a zpracování informací a obsahu se stala aktivní součástí mnoha oborů včetně historických věd. V současnosti se využívá zejména jako virtuální pomocník pro digitaliz…
• New Cancer Immunotherapy and AI-Driven Drug Development
  2026 · AI 驱动科学发现 · Immune checkpoint drugs targeting effector T lymphocytes (such as PD-1 antibody therapies) have revolutionized cancer treatment. However, most tumor patients show limited responses to these drugs. The primary reason lies…
• THE INNER WORKINGS OF RIPENING: PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR INSIGHTs
  2025 · 智慧农业 · Abstract : Fruit ripening is a complex, finely regulated developmental process that transitions fruit from growth to senescence, resulting in enhanced sensory and nutritional attributes. These changes are orchestrated th…
• THE INNER WORKINGS OF RIPENING: PHYSIOLOGY, BIOCHEMISTRY, AND MOLECULAR INSIGHTs
  2025 · 智慧农业 · Abstract : Fruit ripening is a complex, finely regulated developmental process that transitions fruit from growth to senescence, resulting in enhanced sensory and nutritional attributes. These changes are orchestrated th…
• In silico medicine and digital twins (virtual human twins) through the foundational paradigm of in silico oncology: Historical landmarks and current evolutionary status - A Lecture by G. Stamatakos, the Father of In Silico Medicine
  2025 · AI 驱动科学发现 · This document contains the slides of the global lecture of Research Professor Georgios S. Stamatakos, Father of In Silico Medicine, delivered as a webinar of the Avicenna Alliance - Association for Predictive Medicine, u…
• In silico medicine and digital twins (virtual human twins) through the foundational paradigm of in silico oncology: Historical landmarks and current evolutionary status - A Lecture by G. Stamatakos, the Father of In Silico Medicine
  2025 · AI 驱动科学发现 · This document contains the slides of the global lecture of Research Professor Georgios S. Stamatakos, Father of In Silico Medicine, delivered as a webinar of the Avicenna Alliance - Association for Predictive Medicine, u…
• Exploring potential biomarkers for acne based on WGCNA and machine learning algorithms (Preprint)
  2025 · AI 驱动科学发现 · BACKGROUND Acne stands as a prevalent chronic inflammatory dermatological condition, typically characterized by concurrent skin inflammation and scarring. OBJECTIVE Currently, although many studies have been conducted on…
• RESCUE: An end-to-end multi-agent LLM system for proactive rare-disease patient screening in the EHR
  2026 · AI Agent 生态 · Rare diseases affect a significant portion of the global population, yet patients often endure a lengthy diagnostic odyssey, frequently missing the opportunity for timely diagnoses with exome or genome sequencing (ES/GS)…
• Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI-predicted functional consequences.
  2026 · AI 驱动科学发现 · Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global morbidity and mortality, but its genetic architecture remains incompletely understood. This study aims to uncover novel genetic insights into AS…
• Smart Farming Optimization of Phalaenopsis Orchids Growth By Utilizing Fuzzy Logic Control on IoT Architecture
  2022 · 智慧农业 · Tujuan: membangun sistem smart farming yang mampu memonitoring dan mengontrol kondisi serta perawatan terhadap tanaman secara otomatis. Penggunaan website sebagai monitoring dan sistem kontrol mikrokontroller secara real…
• Analysis of multipartite bacterial genomes using alignment free and alignment-based pipelines
  2022 · AI 安全与对齐 · Since the discovery of second chromosome in Rhodobacter sphaeroides 2.4.1 in 1989, multipartite genomes have been reported in over three hundred bacterial species under nine different phyla. This has shattered the unipar…
• Evolution of Plasmid Mobility: Origin and Fate of Conjugative and Nonconjugative Plasmids
  2022 · AI 安全与对齐 · Conjugation drives the horizontal transfer of adaptive traits across prokaryotes. One-fourth of the plasmids encode the functions necessary to conjugate autonomously, the others being eventually mobilizable by conjugatio…
• A review on sox genes in fish
  2021 · AI 安全与对齐 · Abstract The Sry‐related high mobility group box ( Sox ) genes family is a group of transcription factors playing crucial roles during reproduction and development. At least 50% amino acid sequences of Sox protein family…
• A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis
  2021 · AI 安全与对齐 · Pitaya (Hylocereus) is the most economically important fleshy-fruited tree of the Cactaceae family that is grown worldwide, and it has attracted significant attention because of its betalain-abundant fruits. Nonetheless,…
• Smart Farming in Thailand
  2020 · 智慧农业 · Thailand's economic growth depends on agriculture. Roughly 30 to 40 percents of the total employment in Thailand is in the agricultural sector, but this group of people do not earn enough to spend on a daily basis. In th…
• Two androecious mutations reveal the crucial role of ethylene receptors in the initiation of female flower development in Cucurbita pepo
  2020 · AI 安全与对齐 · Ethylene is the key regulator of sex determination in monoecious species of the family Cucurbitaceae. This hormone determines which individual floral meristems develop as female or male flowers and the female flowering t…
• A General Model to Explain Repeated Turnovers of Sex Determination in the Salicaceae
  2020 · AI 安全与对齐 · Dioecy, the presence of separate sexes on distinct individuals, has evolved repeatedly in multiple plant lineages. However, the specific mechanisms by which sex systems evolve and their commonalities among plant species …
• Distinct Expression and Methylation Patterns for Genes with Different Fates following a Single Whole-Genome Duplication in Flowering Plants
  2020 · AI 安全与对齐 · For most sequenced flowering plants, multiple whole-genome duplications (WGDs) are found. Duplicated genes following WGD often have different fates that can quickly disappear again, be retained for long(er) periods, or s…
• Learning from models: high-dimensional analyses on the performance of machine learning interatomic potentials
  2024 · AI 驱动科学发现 · Abstract Machine learning interatomic potential (MLIP) has been widely adopted for atomistic simulations. While errors and discrepancies for MLIPs have been reported, a comprehensive examination of the MLIPs’ performance…
• Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays
  2019 · AI 安全与对齐 · The relationship between noncoding DNA sequence and gene expression is not well-understood. Massively parallel reporter assays (MPRAs), which quantify the regulatory activity of large libraries of DNA sequences in parall…
• Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing
  2018 · AI 安全与对齐 · N6-Methyladenine (m6dA) has been discovered as a novel form of DNA methylation prevalent in eukaryotes; however, methods for high-resolution mapping of m6dA events are still lacking. Single-molecule real-time (SMRT) sequ…
• Potato late blight field resistance from QTL dPI09c is conferred by the NB-LRR gene R8
  2018 · AI 安全与对齐 · Following the often short-lived protection that major nucleotide binding, leucine-rich-repeat (NB-LRR) resistance genes offer against the potato pathogen Phytophthora infestans, field resistance was thought to provide a …
• Future livestock breeding: Precision breeding based on multi-omics information and population personalization
  2017 · 智慧农业 · With the rapid development of molecular biology and related disciplines, animal breeding has moved from conventional breeding to molecular breeding. Marker-assisted selection and genomic selection have become mainstream …
• Estimation of rice protein content before harvest using ground-based hyperspectral imaging and region of interest analysis
  2017 · 智慧农业 · Protein content, which represents rice taste quality, must be estimated in order to create a harvesting plan as well as next year’s basal dressing fertilizer application plan. Ground-based hyperspectral imaging with high…
• Genome‐wide association study discovered candidate genes of Verticillium wilt resistance in upland cotton (Gossypium hirsutum L.)
  2017 · AI 安全与对齐 · Summary Verticillium wilt (VW), caused by infection by Verticillium dahliae, is considered one of the most yield‐limiting diseases in cotton. To examine the genetic architecture of cotton VW resistance, we performed a ge…
• Vineyard zone delineation by cluster classification based on annual grape and vine characteristics
  2016 · 智慧农业 · This study describes a method for vineyard zone delineation based on spatial interpolation of data on annual monitoring of grape and vine growth from 2007 to 2012 for four commercial vines (Cabernet Sauvignon, Mencía, Me…
• Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas
  2014 · AI 安全与对齐 · A fundamental question in evolutionary genetics concerns the roles of mutational pleiotropy and epistasis in shaping trajectories of protein evolution. This question can be addressed most directly by using site-directed …
• Metagenomic Analysis of Viral Communities in (Hado)Pelagic Sediments
  2013 · AI 安全与对齐 · In this study, we analyzed viral metagenomes (viromes) in the sedimentary habitats of three geographically and geologically distinct (hado)pelagic environments in the northwest Pacific; the Izu-Ogasawara Trench (water de…
• Understanding nuclear receptors using computational methods
  2009 · AI 驱动科学发现 · Nuclear receptors (NRs) are important targets for therapeutic drugs. NRs regulate transcriptional activities through binding to ligands and interacting with several regulating proteins. Computational methods can provide …
• Protein Structure Prediction Using Threading
  2008 · AI 驱动科学发现 · This chapter discusses the protocol for computational protein structure prediction by protein threading. First, we present a general procedure and summarize some typical ideas for each step of protein threading. Then, we…
• Solvation model induced structural changes in peptides. A quantum chemical study on Ramachandran surfaces and conformers of alanine diamide using the polarizable continuum model
  2004 · AI 驱动科学发现 · Abstract Potential energy surfaces of the model peptide HCO‐L‐Ala‐NH 2 were calculated using polarizable continuum model (PCM) for the description of aqueous solution at RHF/3‐21G, RHF/6‐31+G(d), and B3LYP/6‐31+G(d) leve…
• The COG database: an updated version includes eukaryotes
  2003 · AI 安全与对齐 · BACKGROUND: The availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an evolutionary classification of genes fr…
• SIX INDEPENDENT LOSSES OF THE CHLOROPLAST DNArpl2 INTRON IN DICOTYLEDONS: MOLECULAR AND PHYLOGENETIC IMPLICATIONS
  1991 · AI 安全与对齐 · Previous studies have shown that in several angiosperms and the liverwort Marchantia the chloroplast gene rpl2, encoding ribosomal protein L2, is interrupted by an intron, but that in spinach (Spinacia oleracea, Caryophy…
• MethylCurate: Tool for Dataset Curation and Epigenetic Aging Clock Evaluation
  2026 · AI Agent 生态 · Summary DNA methylation datasets from public repositories such as NCBI Gene Expression Omnibus are central to the development and evaluation of epigenetic aging clocks, yet existing resources and tools do not fully resol…
• Laboratory Toxicity and Field Efficacy of Four Microbial-Derived Pesticides Combined with Two Adjuvants Against <i>Lygus pratensis</i> (Hemiptera: Miridae).
  2026 · AI Agent 生态 · Systematic field data on adjuvant-amended microbial-derived pesticides against L. pratensis in arid, high-ultraviolet cotton regions remain scarce. This study systematically evaluated the laboratory toxicity and field ef…
• A Synthetic Minimal Genome Design Framework for Bacteriophages: Application to <em>Streptococcus mutans</em> and Broad-Host-Range Expression in <em>Escherichia coli</em>
  2026 · AI Agent 生态 · Minimal genome design, reducing a system to its smallest functional part set, is a core synthetic-biology strategy. Bacteriophages are attractive but underused chassis, yet wild-type phages are difficult to engineer. We …
• Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.
  2026 · AI Agent 生态 · Medium-chain carboxylic acids, such as n-caproate, are attractive sustainable platform chemicals. However, their microbial production is often limited by electron availability and low product selectivity. This study inve…
• Alpha-herpesvirus UL55 synergizes with ICP27 to suppress type I interferon production through conserved and host-adapted mechanisms.
  2026 · 智慧农业 · Herpesviruses employ sophisticated immune evasion strategies to establish lifelong infections, subverting type I interferon (IFN-I) responses critical for antiviral defense. However, their adaptive mechanisms across spec…
• A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits
  2026 · 智慧农业 · Non-coding regulatory variation drives complex traits, domestication, and evolutionary adaptation, yet the sheep genome lacks high-resolution functional annotation. Here we present SheepEpimap, a multi-tissue regulatory …
• Genome Editing in Root and Tuber Crop Development in Sub-Saharan Africa.
  2026 · 智慧农业 · Precision genome editing, particularly using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), is advancing crop improvement by enabling targeted and efficient genetic…
• Precision-fermented milk proteins as a model for industrial food biotechnology.
  2026 · 智慧农业 · Dairy proteins are among the most nutritionally and functionally valuable proteins used in food, clinical nutrition, and infant nutrition, yet their supply remains structurally linked to livestock production and dairy pr…
• Genome Editing Approaches in Flax (&lt;i&gt;Linum usitatissimum&lt;/i&gt; L.): From Tools to Trait Improvement.
  2026 · 智慧农业 · Genome editing, particularly CRISPR/Cas-based systems, has emerged as a key tool for functional genomics and trait improvement in flax ( Linum usitatissimum L.), an important fiber and oilseed crop. This review focuses s…
• Advances in Fish Gene Editing.
  2026 · 智慧农业 · Fish represent the most species-rich group within the phylum Chordata, possessing exceptional nutritional and ornamental value. Global aquaculture, particularly finfish farming, is experiencing rapid expansion worldwide,…
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas genome editing transforming crop stress tolerance for global food security.
  2026 · 智慧农业 · Climate change increasingly threatens global crop productivity by intensifying drought, salinity, temperature extremes, and biotic stresses. Developing climate-resilient cultivars has therefore become a central objective…
• Precision Fermentation of Recombinant Myofibrillar Proteins for Future Foods.
  2026 · 智慧农业 · Myofibrillar proteins, namely, actin and myosin, are responsible for many of the textural attributes of animal-based meat. Precision fermentation (recombinant production of food ingredients) represents an underexplored a…
• Genome-Wide Identification of the WD40 Gene Family and Functional Analysis of a Candidate Gene Regulating Seed Quality in Soybean.
  2026 · 智慧农业 · Background : Soybean is an important crop with multiple uses for oil, food, and feed, providing 50% of the vegetable protein and 20% of the edible oil in the world. The WD40 family genes play crucial regulatory roles in …
• SOCS2 regulation myoblast differentiation of Hu sheep via STAT3/PSMB9 pathway.
  2026 · 智慧农业 · SOCS2 is known to regulate myoblast differentiation and skeletal muscle development via the GH-IGF1 axis, while its role in Hu sheep myoblast differentiation and its potential alternative signaling pathways remain largel…
• Integrated Comparative Genomics and Population Genomics Reveal the Genomic and Epigenomic Basis of Barley (&lt;i&gt;Hordeum vulgare&lt;/i&gt;) Evolution and Domestication.
  2026 · 智慧农业 · Barley ( Hordeum vulgare ) is one of the earliest domesticated cereal crops and remains important for global feed, food, and malting industries. Although high-quality genomic resources are now available, its large repeat…
• Integrated DIA-PRM proteomics Deciphers the molecular mechanisms and identifies core biomarkers of relative resistance to decapod iridescent Virus 1 (DIV1) in Macrobrachium rosenbergii.
  2026 · 智慧农业 · Macrobrachium rosenbergii is a pillar species in global freshwater crustacean aquaculture. Decapod iridescent virus 1 (DIV1) causes 60%-90% cumulative mortality in cultured ponds, leading to massive economic losses with …
• Effects of Dietary Metabolizable Energy and Crude Protein on Postprandial Metabolite Dynamics and Lactation Performance in Dairy Goats.
  2026 · 智慧农业 · Background: Dietary metabolizable energy (ME) and crude protein (CP) levels are important for lactation performance and metabolic responses in dairy ruminants. This study aimed to evaluate the effects of dietary ME and C…
• Multi-species Comparative Analysis Identifies Conserved Enhancers for Improving Casein Expression via Gene Editing.
  2026 · 智慧农业 · As the global population continues to grow, the demand for protein is correspondingly increasing. Milk serves as a significant source of high-quality protein, with casein being its primary nutrient. Consequently, the cul…
• Mechanistic insights on dynamic high-pressure microfluidization pretreatment of cassava starch to enhance the 3D printing accuracy of inks.
  2026 · 智慧农业 · This study investigated the mechanism of dynamic high-pressure microfluidization pretreatment to enhance cassava starch ink printability. The high-cycle modification improved the printing precision to 94.82 ± 0.14%, a 20…

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