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biochemistry

GeneTech 知识引擎共收录 2187 篇相关科研实体，横跨 30 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• Genome-Wide Characterization of the <i>Botryosphaeria dothidea</i> GH28 Family Reveals BdGH28_3 Contributes to Virulence on Chinese Hickory.
  2026 · AI 驱动科学发现 · Chinese hickory ( Carya cathayensis Sarg.) is an economically important tree species widely cultivated in southeastern China, where trunk canker disease caused by Botryosphaeria dothidea poses a serious threat to tree he…
• Label-Free Impedance-Activated Acoustic Sorting of Cells From Structural to Molecular Scale in Microfluidics.
  2026 · AI 驱动科学发现 · Label-free, noninvasive, and high-throughput analysis and sorting of cells are essential capabilities in modern biomedicine, particularly for investigating cellular heterogeneity, functional phenotyping, and precision me…
• High-throughput discovery of Li<sub>3</sub>Sc<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> as a protective coating for stabilizing mid-Ni NCM interfaces in all-solid-state batteries.
  2026 · AI 驱动科学发现 · As all-solid-state battery (ASSB) technologies continue to advance, interest has resurfaced in mid-nickel (mid-Ni) LiNi x Co y Mn z O 2 (NCM; x = 0.5) cathodes due to their enhanced structural stability, re…
• Machine Learning Interatomic Potential-Enabled Discovery of Chlorofullerenes.
  2025 · AI 驱动科学发现 · Abstract Chlorination is an effective method for stabilizing fullerenes with pentagon adjacencies, transforming reactive sp 2 carbon sites into sp 3 hybridization to release local strain and reorganize orbital and spin d…
• Chromosome alignment relies on spindle-localized control of Cdk1 activity
  2024 · AI 安全与对齐 · Abstract During mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells. A central role for chromosome alignment is exerted by the …
• Ammonium and nitrate regulate NH4+ uptake activity of Arabidopsis ammonium transporter AtAMT1;3 via phosphorylation at multiple C-terminal sites
  2019 · AI 安全与对齐 · In plants, nutrient transporters require tight regulation to ensure optimal uptake in complex environments. The activities of many nutrient transporters are post-translationally regulated by reversible phosphorylation, a…
• Non-targeted profiling of semi-polar metabolites in Arabidopsis root exudates uncovers a role for coumarin secretion and lignification during the local response to phosphate limitation
  2015 · AI 安全与对齐 · Plants have evolved two major strategies to cope with phosphate (Pi) limitation. The systemic response, mainly comprising increased Pi uptake and metabolic adjustments for more efficient Pi use, and the local response, e…
• Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates
  2010 · AI 安全与对齐 · BACKGROUND: The beta-carbonic anhydrase (CA, EC 4.2.1.1) enzymes have been reported in a variety of organisms, but their existence in animals has been unclear. The purpose of the present study was to perform extensive se…
• Identification and characterization of the metal ion‐dependent l ‐alanoyl‐ d ‐glutamate peptidase encoded by bacteriophage T5
  2009 · AI 安全与对齐 · Although bacteriophage T5 is known to have lytic proteins for cell wall hydrolysis and phage progeny escape, their activities are still unknown. This is the first report on the cloning, expression and biochemical charact…
• Understanding nuclear receptors using computational methods
  2009 · AI 驱动科学发现 · Nuclear receptors (NRs) are important targets for therapeutic drugs. NRs regulate transcriptional activities through binding to ligands and interacting with several regulating proteins. Computational methods can provide …
• Solvation model induced structural changes in peptides. A quantum chemical study on Ramachandran surfaces and conformers of alanine diamide using the polarizable continuum model
  2004 · AI 驱动科学发现 · Abstract Potential energy surfaces of the model peptide HCO‐L‐Ala‐NH 2 were calculated using polarizable continuum model (PCM) for the description of aqueous solution at RHF/3‐21G, RHF/6‐31+G(d), and B3LYP/6‐31+G(d) leve…
• The primary structure of UK 114 tumor antigen
  1996 · AI 安全与对齐 · UK114 is a tumor antigen expressed by various malignant neoplasms. The complete amino acid sequence of UK114 purified from goat liver has been determined by automated Edman degradation of CNBr and endoproteinase Lys-C pe…
• Total Flavonoids from <i>Carthamus tinctorius</i> L. Reduce Liver Fibrosis by Influencing Autophagy via Hedgehog Signaling.
  2026 · AI Agent 生态 · Liver fibrosis is a critical determinant of the progression of chronic liver disease (CLD). Total flavonoids from Carthamus tinctorius L. (TFCTLs) exhibit diverse pharmacological activities while their effect on liver fi…
• Research on the Highly Efficient and Low-Dose Improvement of Alcohol-Induced Liver Injury by High-Selenium-Content Modified Lycium barbarum Polysaccharides.
  2026 · AI Agent 生态 · There are currently no FDA-approved drugs for the treatment of alcohol-related liver diseases (ALD) due to their lack of effectiveness. Selenium-modified Lycium barbarum polysaccharides (SeLBP), as a promising agent for …
• AI-driven discovery of bronopol for the treatment of pulmonary fibrosis via inhibition of fibroblast activation.
  2026 · AI Agent 生态 · Aims Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Epigenetic regulation by p300 histone acetyltransferase plays a central role in fibroblast activation and fi…
• Precision oncology in the age of AI: lessons from AI-driven drug discovery and clinical translation.
  2026 · AI Agent 生态 · Drug discovery has been constrained by extended timelines and high costs, as the cumulative requirements of preclinical validation, multi-phase clinical trials, and regulatory approval have been imposed. Recently, comput…
• Leucoseptoside a reverses multidrug resistance in breast cancer cells by targeting P-glycoprotein (P-gp/ABCB1) transporter.
  2026 · AI Agent 生态 · The overexpression of P-glycoprotein (P-gp) in tumour cells and its mediated drug efflux represent key mechanisms of cancer multidrug resistance (MDR). Natural compounds are attractive candidates for reversing MDR due to…
• Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.
  2026 · AI Agent 生态 · Medium-chain carboxylic acids, such as n-caproate, are attractive sustainable platform chemicals. However, their microbial production is often limited by electron availability and low product selectivity. This study inve…
• Metal-polyphenol nanomedicines for malignant tumor therapy.
  2026 · AI Agent 生态 · Malignant tumor is still one of the most critical diseases in clinic. Current therapeutic strategies include surgery, chemoradiotherapy, targeted therapy, and immunotherapy. Nevertheless, the development of novel drugs w…
• Protocatechuic Acid Alleviates D-Gal-Induced Renal Senescence and Injury in Mice by Regulating Taurine Metabolism.
  2026 · AI Agent 生态 · Protocatechuic acid (PCA), a natural phenolic compound with antioxidant and anti-inflammatory properties, has been proposed as a potential therapeutic agent against aging-related diseases. This study investigated the pro…
• 12-Hydroxylauric Acid-Tethered Heterochiral Diphenylalanines: A Promising Antimicrobial Peptide Scaffold for <i>In Vivo</i> Wound Healing Applications.
  2026 · AI Agent 生态 · Microbial infections are among the most critical global issues, imposing a significant financial burden on healthcare systems worldwide. Despite extensive efforts, the development of effective therapeutics remains in its…
• Quercetin in COPD: A Multi-Target Approach to Modulate Inflammation, Oxidative Stress, and Epithelial Dysfunction.
  2026 · AI Agent 生态 · Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder that affects millions of people globally. Although the mechanisms of COPD pathogenesis are not completely known, oxidative stress and lung infla…
• Unveiling the multifaceted roles of crop secondary metabolites: From quality enhancement and stress resilience to molecular regulation and precision improvement.
  2026 · 智慧农业 · Crops are fundamental to global food security, yet their production and quality are increasingly challenged by climate change, resource limitations, and both biotic and abiotic stresses. Secondary metabolites play crucia…
• Disruption of cellular timekeeping in cancer: links between circadian clocks, metabolism, and tumor progression.
  2026 · 智慧农业 · Disruption of cellular timekeeping systems is a key driver of cancer cell development and progression. The circadian clock is a 24-hour regulatory system that relies on core clock genes - CLOCK, BMAL1, PER, and CRY. Main…
• Targeting the PRMT1 axis in cancer: from epigenetic plasticity to contextual therapeutic interventions.
  2026 · 智慧农业 · Protein arginine methyltransferase 1 (PRMT1), the predominant Type I arginine methyltransferase, is reported to play the key role in regulating cancer epigenetics. Its activity directs gene expression, chromatin structur…
• More efficient and precise toward application of tomato-derived lycopene: a state-of-the-art review into sources, chemistry, extraction methods, bioavailability, and uniting power in fatty liver disease.
  2026 · 智慧农业 · Fatty liver disease (FLD) is among the most prevalent chronic liver disorders worldwide. Tomato-derived lycopene has received considerable attention as a functional bioactive compound due to its strong antioxidant and an…
• Melatonin-mediated redox regulation in fruits: modulating oxidative signaling for quality preservation.
  2026 · 智慧农业 · Main conclusion Melatonin is a key regulator of postharvest redox homeostasis, enhancing antioxidant defenses and coordinating ROS signaling. Its application effectively delays senescence, preserves fruit quality, and of…
• Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.
  2026 · 智慧农业 · Root system architecture (RSA) is pivotal to plant nutrient acquisition and environmental adaptation. In recent years, peptide hormones-intercellular signaling molecules that act locally or systemically-have emerged as c…
• Precision Fermentation of Recombinant Myofibrillar Proteins for Future Foods.
  2026 · 智慧农业 · Myofibrillar proteins, namely, actin and myosin, are responsible for many of the textural attributes of animal-based meat. Precision fermentation (recombinant production of food ingredients) represents an underexplored a…
• Targeted free amino acid, nucleotide, and untargeted lipidomic profiling reveal tissue-specific chemical composition and nutritional heterogeneity in Manila clam.
  2026 · 智慧农业 · Background The Manila clam is a highly nutritious and sought-after shellfish; however, a lack of detailed knowledge regarding tissue-specific chemical composition hinders precision processing and contributes to waste. Th…
• SOCS2 regulation myoblast differentiation of Hu sheep via STAT3/PSMB9 pathway.
  2026 · 智慧农业 · SOCS2 is known to regulate myoblast differentiation and skeletal muscle development via the GH-IGF1 axis, while its role in Hu sheep myoblast differentiation and its potential alternative signaling pathways remain largel…
• Effects of Dietary Metabolizable Energy and Crude Protein on Postprandial Metabolite Dynamics and Lactation Performance in Dairy Goats.
  2026 · 智慧农业 · Background: Dietary metabolizable energy (ME) and crude protein (CP) levels are important for lactation performance and metabolic responses in dairy ruminants. This study aimed to evaluate the effects of dietary ME and C…
• Assessment on the effects of different lipid sources in juvenile largemouth bass (Micropterus salmoides) diets.
  2026 · 智慧农业 · To evaluate the effects of substituting soybean oil (SO) with soy lecithin (SL) and specialty lipid (CL) on the growth, body composition, and glucose-lipid metabolism of juvenile largemouth bass (Micropterus salmoides). …
• The gene homologous to OsCd1, designated as ABNORMAL SHOOT IN YOUTH (OsASY), functions as a cadmium influx transporter in rice.
  2026 · 智慧农业 · Cadmium (Cd) contamination in rice threatens food security and public health. Identifying and characterizing key genes governing Cd uptake and translocation is crucial for breeding low-Cd varieties. In this study, we cha…
• Pyrroloquinoline quinone enhances in vitro maturation of porcine oocytes and supports ensuing embryonic development.
  2026 · 智慧农业 · Oxidative stress, driven by an imbalance between reactive oxygen species (ROS) production and antioxidant capacity (particularly glutathione, GSH), contributes significantly to the poor quality of in vitro maturation (IV…
• Precision oncology in the age of AI: lessons from AI-driven drug discovery and clinical translation.
  2026 · AI 安全与对齐 · Drug discovery has been constrained by extended timelines and high costs, as the cumulative requirements of preclinical validation, multi-phase clinical trials, and regulatory approval have been imposed. Recently, comput…
• Will predictive AI make discovery research in metabolism obsolete.
  2026 · AI 安全与对齐 · Human metabolism operates as a deeply interconnected network that maintains metabolic homoeostasis by coordinating glucose and lipid utilization, amino acid synthesis, and other core biochemical processes with the handli…
• HighRes_Builder: improved access and modeling of noncanonical residues for protein structure prediction.
  2026 · AI 驱动科学发现 · The growing support for noncanonical amino acids in structure prediction tools such as AlphaFold3 has been largely facilitated by the Chemical Component Dictionary (CCD). However, the limited coverage of modified residue…
• Functional role of the diadenylate cyclase gene cdaA in stress responses of the dairy starter Streptococcus thermophilus.
  2026 · AI 驱动科学发现 · Streptococcus thermophilus is a key dairy starter culture widely used in the production of yogurt and cheese, where its robustness in stress adaptation and growth performance is critical for industrial fermentation effic…
• Gain- and loss-of-function of Engrailed 1 in mesenchymal stromal cells affect their potential to differentiate into osteoblasts and to repair bone tissue.
  2026 · AI 驱动科学发现 · Engrailed 1 (En1) is a developmental transcription factor associated with skeletal formation; however, its functional role in mesenchymal stromal cell (MSC)-driven osteogenesis remains poorly understood. Here, we demonst…
• Lumican deficiency dysregulates trophoblast function via PI3K/AKT and P53 signaling in preeclampsia.
  2026 · AI 驱动科学发现 · Lumican, an extracellular matrix (ECM) component highly expressed in placenta, is implicated in preeclampsia (PE) pathogenesis, though its precise mechanisms in trophoblast function and PE development remain unclear. Tra…
• Comparative Study of Effects of Different Organic Acid Treatments on Preservation Quality of Two Bamboo Shoot Species Using PCA Comprehensive Evaluation and Quality Index Models.
  2026 · AI 驱动科学发现 · Bamboo shoots undergo rapid postharvest quality deterioration. To evaluate the effects of organic acid treatments on the quality preservation of green bamboo ( Dendrocalamopsis oldhami ) shoots (GBSs) and lei bamboo ( Ph…
• CXCL9/SPP1-polarized tumor-associated macrophages exert dual roles in regulating anti-tumor immunity in lung adenocarcinoma.
  2026 · AI 驱动科学发现 · Background CS polarity, the mutually exclusive expression of CXCL9 and SPP1, is a key feature of tumor-associated macrophages (TAMs) in the lung adenocarcinoma (LUAD) microenvironment. The mechanisms and impact of CS pol…
• USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders.
  2026 · AI 驱动科学发现 · Perioperative neurocognitive disorders (POCD) are a class of common complications of central nervous system after general anesthesia and surgery. Sevoflurane (SEV) is a widely used inhalation anesthetic in clinical pract…
• AI-Driven Discovery of a Hydrophobic-Tag Degrader Targeting NSD3 for Lung Squamous Carcinoma Therapy.
  2026 · AI 驱动科学发现 · Nuclear receptor-binding SET domain protein 3 (NSD3) is a histone H3K36 methyltransferase implicated in lung squamous cell carcinoma, yet chemical targeting is challenging due to the shallow PWWP reader pocket. Here, we …
• Generative AI–Driven Design and Experimental Validation of EGFPAN_EMBS, a Novel EGFR Inhibitor in Pancreatic Cancer
  2026 · AI 驱动科学发现 · Abstract Pancreatic cancer remains a highly lethal malignancy with limited targeted therapeutic options, necessitating innovative drug discovery strategies. The epidermal growth factor receptor (EGFR) is a key driver of …
• Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress.
  2026 · AI 驱动科学发现 · Dry eye disease (DED) is a prevalent, age-related ocular disorder that severely impairs vision and quality of life. Age-related cellular senescence drives disease progression through the senescence-associated secretory p…
• Spatiotemporally Controlled Lysosomal Membrane Permeabilization Amplifies STING-Driven Antitumor Immunity in Prostate Cancer.
  2026 · AI 驱动科学发现 · Prostate cancer (PCa) remains a major clinical challenge due to therapeutic resistance and immunologically cold tumor microenvironment. Lysosomal membrane permeabilization (LMP)-induced lysosome-dependent cell death offe…
• Hierarchical engineering of mesoporous polydopamine for "homologous targeting-cascade blasting" biomimetic phototheranostic nanotrident.
  2026 · AI 驱动科学发现 · The activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway represents a promising strategy for eliciting host immune responses to eradicate tumors. However, the clinical applicati…
• Discovery of four new malabaricane saponins, malabarosides A-D, from the aerial parts of Dysphania ambrosioides with nitric oxide production inhibitory activity.
  2026 · AI 驱动科学发现 · The plant Dysphania ambrosioides has long been best known for its traditional use as a medicine to treat worms and other intestinal parasites, as well as for treating wounds. Phytochemical study of the methanol extract o…
• Cluster of differentiation 36-engineered photosynthetic cyanobacteria enable immunometabolic reprogramming in triple-negative breast cancer.
  2026 · AI 驱动科学发现 · Triple-negative breast cancer (TNBC) exhibits profound resistance to immunotherapy, largely due to a tumor microenvironment constrained by dysregulated lipid metabolism and persistent hypoxia. Excessive fatty acid uptake…
• Structure-guided engineering of AI-derived adenine base editors for nuclear and mitochondrial DNA editing.
  2026 · AI 驱动科学发现 · Traditional adenine base editors (ABEs), primarily derived from TadA, suffer from bystander editing and limited diversity, while artificial intelligence (AI)-designed deaminases such as Deam-P32 exhibit lower efficiency …
• Intrinsically Mitochondria-Targeting Nanozyme via Coordination-Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia-Reperfusion Injury.
  2026 · AI 驱动科学发现 · Mitochondrial dysfunction, culminating in oxidative stress-driven release of mitochondrial DNA (mtDNA) and subsequent inflammatory activation, constitutes a central pathogenic axis in cerebral ischemia-reperfusion injury…
• AI-driven discovery of bronopol for the treatment of pulmonary fibrosis via inhibition of fibroblast activation.
  2026 · AI 驱动科学发现 · Aims Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Epigenetic regulation by p300 histone acetyltransferase plays a central role in fibroblast activation and fi…
• 20S proteasome-regulated proteostasis in ELVAs is critical for oocyte-to-embryo transition and female fertility.
  2026 · AI 驱动科学发现 · Programmed degradation of maternal proteins is essential for the oocyte-to-embryo transition (OET). While pharmacological inhibition studies have established the importance of proteasomes in ovarian reserve maintenance, …
• Enhancement of Pediocin Production in <i>Pediococcus pentosaceus</i> SNSS18 by Exogenous Amino Acids and Nucleobases: A Mechanistic Elucidation.
  2026 · AI 驱动科学发现 · Amino acids and nucleobases, as essential nutrients for lactic acid bacteria (LAB), play a pivotal role in their growth and metabolism. However, their specific effects on pediocin production and the underlying regulatory…
• SignalGen: A Protein Language Model Based AI Agent For Optimal Signal Peptide Prediction
  2025 · AI Agent 生态 · Signal peptides are short amino acid sequences attached to the N-termini of mature proteins. They play determinant roles in protein expression as well as localization of mature proteins. While sequence-based machine lear…
• HighPlay: Cyclic Peptide Sequence Design Based on Reinforcement Learning and Protein Structure Prediction.
  2025 · AI 驱动科学发现 · The structural diversity and good biocompatibility of cyclic peptides have led to their emergence as potential therapeutic agents. Existing cyclic peptide design methods, whether traditional or emerging AI-assisted, rely…
• Tardigrade-Derived Strategy for Low-Cost Storage of Cell-Free Expression Lysates
  2026 · AI Agent 生态 · Cell-free expression systems (CFES) are increasingly used alongside conventional biotechnological approaches to accelerate early-stage prototyping and are particularly valuable in point-of-use settings. However, their br…
• Single-Cell Transcriptomic Signatures Enable Stratified Combination Therapy for Platinum-Resistant Ovarian Cancer
  2026 · AI Agent 生态 · In high-grade serous carcinoma (HGSC), extensive intra-tumoral heterogeneity hinders complete eradication and remains a major obstacle to developing combination therapies capable of eliminating subpopulations resistant t…

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