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biochemistry

GeneTech 知识引擎共收录 190 篇相关科研实体，横跨 20 个垂直领域。数据来自 OpenAlex、arXiv、Crossref、PubMed、Europe PMC 等公开学术源，全部可溯源到原文。

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• Variations in host-seeking behaviour and molecular insights by some newly isolated Himalayan strains of entomopathogenic nematode, <i>Heterorhabditis bacteriophora</i>
  2026 · 脑科学 · The present study investigates the variations in host recognition behaviour of five newly isolated Himalayan strains of Heterorhabditis bacteriophora towards greater wax moth, Galleria mellonella (Linnaeus, 1758; Lepidop…
• Variations in host-seeking behaviour and molecular insights by some newly isolated Himalayan strains of entomopathogenic nematode, <i>Heterorhabditis bacteriophora</i>
  2026 · 脑科学 · The present study investigates the variations in host recognition behaviour of five newly isolated Himalayan strains of Heterorhabditis bacteriophora towards greater wax moth, Galleria mellonella (Linnaeus, 1758; Lepidop…
• A pantothenic acid deficiency outbreak causing mortality and neuromuscular disorders in newborn and nursery piglets
  2026 · 脑科学 · Abstract Background The present case report describes the clinical and pathological outcomes of an outbreak of piglet mortality and neuromuscular disorders in newborn and nursery piglets caused by vitamin B5 deficiency. …
• A pantothenic acid deficiency outbreak causing mortality and neuromuscular disorders in newborn and nursery piglets
  2026 · 脑科学 · Abstract Background The present case report describes the clinical and pathological outcomes of an outbreak of piglet mortality and neuromuscular disorders in newborn and nursery piglets caused by vitamin B5 deficiency. …
• Clinical-pathological diagnostic concordance in inflammatory dermatoses: a single-center retrospective analysis
  2026 · 脑科学 · Inflammatory dermatoses are a heterogeneous group with overlapping clinical presentations, often requiring histopathological confirmation. The concordance between clinical impression and pathological diagnosis remains un…
• Clinical-pathological diagnostic concordance in inflammatory dermatoses: a single-center retrospective analysis
  2026 · 脑科学 · Inflammatory dermatoses are a heterogeneous group with overlapping clinical presentations, often requiring histopathological confirmation. The concordance between clinical impression and pathological diagnosis remains un…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
  2026 · 脑科学 · Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience…
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• The evolving bioinformatic approaches to identifying genetic targets of promise in cancers
  2026 · 基因技术工具 · The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficient to capture…
• Mechanistic insights into the anticancer effects of apigenin in ovarian cancer: A systematic review
  2026 · 生命科学 · Ovarian cancer remains a leading cause of death among gynecological malignancies, characterized by high mortality rates and significant resistance to conventional treatments. Natural compounds, such as apigenin, a plant-…
• Mechanistic insights into the anticancer effects of apigenin in ovarian cancer: A systematic review
  2026 · 生命科学 · Ovarian cancer remains a leading cause of death among gynecological malignancies, characterized by high mortality rates and significant resistance to conventional treatments. Natural compounds, such as apigenin, a plant-…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Biomimetic fusion nanosystem from ginger exosomes and tumor cell membranes: boosting PLK1-targeted therapy in BRCA-heterogeneous HGSOC
  2026 · 生命科学 · Abstract High-grade serous ovarian carcinoma (HGSOC) remains a lethal malignancy with few effective therapeutic options. In this study, we systematically evaluated the anti-tumor effect of Bi2536, an inhibitor of Polo-li…
• Quantifying the spatio-temporal sensitivity of NO₂ to daily human activities through interpretable machine learning: a case study in the USA
  2026 · 低空经济 · Human activities, such as mobility, manufacturing, and energy consumption, are major drivers of nitrogen dioxide (NO 2 ) emissions. Understanding the relationship between human activities and NO 2 emissions can help desi…
• Quantifying the spatio-temporal sensitivity of NO₂ to daily human activities through interpretable machine learning: a case study in the USA
  2026 · 低空经济 · Human activities, such as mobility, manufacturing, and energy consumption, are major drivers of nitrogen dioxide (NO 2 ) emissions. Understanding the relationship between human activities and NO 2 emissions can help desi…
• Multi-disciplinary study of a new 3D cobalt (II) complex: from crystal engineering to antimicrobial drug potential
  2026 · 半导体与先进封装 · This study reports the preparation, spectroscopic characterization, and biological evaluation of a novel three-dimensional coordination complex, C 10 H 24 N 6 [Co(SCN) 4 ]. The compound crystallizes in the P2 1 /n space …
• Multi-disciplinary study of a new 3D cobalt (II) complex: from crystal engineering to antimicrobial drug potential
  2026 · 半导体与先进封装 · This study reports the preparation, spectroscopic characterization, and biological evaluation of a novel three-dimensional coordination complex, C 10 H 24 N 6 [Co(SCN) 4 ]. The compound crystallizes in the P2 1 /n space …
• Biosynthesis of medium-chain length polyhydroxyalkanoates from pre-treated food wastewater
  2026 · 合成生物与生物制造 · Abstract Background The escalating global plastic waste crisis, coupled with the challenges of managing high-moisture food waste from industrial processing, has prompted nations worldwide to pursue sustainable alternativ…
• Biosynthesis of medium-chain length polyhydroxyalkanoates from pre-treated food wastewater
  2026 · 合成生物与生物制造 · Abstract Background The escalating global plastic waste crisis, coupled with the challenges of managing high-moisture food waste from industrial processing, has prompted nations worldwide to pursue sustainable alternativ…
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  2026 · 合成生物与生物制造 · Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable…
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
  2026 · 合成生物与生物制造 · Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable…
• Recent advances in the development of small molecule STK33 inhibitors
  2026 · 合成生物与生物制造 · The serine/threonine kinase 33 (STK33) has attracted attention in recent years as a synthetic-lethal partner of oncogenic KRAS, thereby representing a potential indirect route to target KRAS-driven cancers. Initially, RN…
• Recent advances in the development of small molecule STK33 inhibitors
  2026 · 合成生物与生物制造 · The serine/threonine kinase 33 (STK33) has attracted attention in recent years as a synthetic-lethal partner of oncogenic KRAS, thereby representing a potential indirect route to target KRAS-driven cancers. Initially, RN…
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  2026 · 合成生物与生物制造 · Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-produc…
• Tri-valorization of methanol in a single bioreactor: co-production of enzyme, chemical, and single-cell protein using engineered Pichia pastoris (Komagataella phaffii)
  2026 · 合成生物与生物制造 · Abstract The economic viability of methanol-based biomanufacturing, particularly with green methanol as feedstock, is often limited by the low value of single-product processes. Here, we developed an integrated co-produc…
• Research progress on the mechanisms of bidirectional fermentation-driven structural diversification of natural products
  2026 · 合成生物与生物制造 · Natural medicines play a significant role in disease prevention and treatment due to their diverse biological activities. However, their complex chemical composition, low concentrations of active compounds, and toxicity …
• Research progress on the mechanisms of bidirectional fermentation-driven structural diversification of natural products
  2026 · 合成生物与生物制造 · Natural medicines play a significant role in disease prevention and treatment due to their diverse biological activities. However, their complex chemical composition, low concentrations of active compounds, and toxicity …
• Methanol-based biosynthesis of p-coumaric acid by engineered Pichia pastoris
  2026 · 合成生物与生物制造 · Abstract p-Coumaric acid (p-CA) is a key aromatic precursor for the biosynthesis of flavonoids, stilbenoids, and other high-value phenylpropanoids. While microbial production of p-CA typically relies on sugar-based subst…
• Beyond antitumor activity and from lichenized fungi: advances in the production, bioactivities, synthesis, and biosynthesis of usnic acid and its structural derivatives
  2026 · 合成生物与生物制造 · Usnic acid and its structural derivatives are dibenzofuran natural products characterized by a distinctive 6-5-6 tricyclic scaffold. These compounds, isolated from lichenized fungi, non-lichenized fungi, and select highe…
• Beyond antitumor activity and from lichenized fungi: advances in the production, bioactivities, synthesis, and biosynthesis of usnic acid and its structural derivatives
  2026 · 合成生物与生物制造 · Usnic acid and its structural derivatives are dibenzofuran natural products characterized by a distinctive 6-5-6 tricyclic scaffold. These compounds, isolated from lichenized fungi, non-lichenized fungi, and select highe…
• A superfamily of bioactive proteins from fungi - are these secondary metabolites?
  2026 · 合成生物与生物制造 · Abstract Background Since decades, fungi are leveraged in biotechnology to produce high-value compounds used in multiple economic sectors. Strain and process optimisation is based on a comprehensive understanding of the …
• A superfamily of bioactive proteins from fungi - are these secondary metabolites?
  2026 · 合成生物与生物制造 · Abstract Background Since decades, fungi are leveraged in biotechnology to produce high-value compounds used in multiple economic sectors. Strain and process optimisation is based on a comprehensive understanding of the …
• Drying kinetics and metabolite dynamics of rhubarb during shade drying
  2026 · 中医药工具 · Rhubarb, valued in traditional Chinese medicine for both medicinal and edible uses, requires effective postharvest drying. Shade drying’s impact on its metabolic profile remains insufficiently studied. Fresh three-year-o…
• Drying kinetics and metabolite dynamics of rhubarb during shade drying
  2026 · 中医药工具 · Rhubarb, valued in traditional Chinese medicine for both medicinal and edible uses, requires effective postharvest drying. Shade drying’s impact on its metabolic profile remains insufficiently studied. Fresh three-year-o…
• Xiaoqinglong Decoction Attenuates Allergic Rhinitis Comorbid with Asthma via Modulation of the ALOX15/GPX4 Axis
  2026 · 中医药工具 · Objective: Xiaoqinglong Decoction (XQLD) is a classical traditional Chinese medicine (TCM) formula for allergic rhinitis (AR) and asthma. However, its underlying therapeutic mechanisms in allergic rhinitis comorbid with …
• Xiaoqinglong Decoction Attenuates Allergic Rhinitis Comorbid with Asthma via Modulation of the ALOX15/GPX4 Axis
  2026 · 中医药工具 · Objective: Xiaoqinglong Decoction (XQLD) is a classical traditional Chinese medicine (TCM) formula for allergic rhinitis (AR) and asthma. However, its underlying therapeutic mechanisms in allergic rhinitis comorbid with …
• Unlocking the therapeutic potential of <i>Thymus serpyllum</i> L.: A systematic review of ethnopharmacology, phytochemistry and biological activity
  2026 · 中医药工具 · Thymus serpyllum L. (wild thyme) is an important panacea herb used in European and Asian countries to cure different ailments. Owing to its diverse chemical constituents concomitant with biological activities, it is wide…
• Unlocking the therapeutic potential of <i>Thymus serpyllum</i> L.: A systematic review of ethnopharmacology, phytochemistry and biological activity
  2026 · 中医药工具 · Thymus serpyllum L. (wild thyme) is an important panacea herb used in European and Asian countries to cure different ailments. Owing to its diverse chemical constituents concomitant with biological activities, it is wide…
• Computational insights into mercuric reductase from <i>Pseudomonas fluorescens</i>: a bioinformatic and molecular dynamics approach for mercury detoxification
  2025 · AI 驱动科学发现 · Mercury (Hg) pollution poses significant threats to human health and ecosystems worldwide due to its persistence, bioaccumulation, and toxic effects. This study focuses on mercuric reductase from Pseudomonas fluorescens …
• Catalytic Effects on Aldose Formation by γ-ray-Induced Formose-Type Reactions in Meteorite Parent Bodies
  2025 · 地外矿物 · High Resolution Image Download MS PowerPoint Slide The formose-type reaction is widely regarded as a key process in the formation of sugars including ribose, a component of RNA, which is essential for life. Aqueous alter…
• 2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
  2025 · 脑科学 · Valosin-containing protein (VCP/p97) is a ubiquitously expressed AAA+ ATPase associated with numerous protein-protein interactions and critical cellular functions including protein degradation and clearance, mitochondria…
• ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis
  2025 · 深海科技 · Lipid peroxidation stands as a prominent hallmark and a prerequisite for the onset of ferroptosis. Lipid metabolism holds a pivotal role in regulating this process, forming the metabolic foundation for cellular sensitivi…
• “Twin transition” and HRM practices: empirical evidence from Italian firms
  2025 · 数字孪生 · The increasing policy emphasis on achieving a joint green and digital transformation – referred to as the ‘twin transition’ is driving techno-organisational change in new directions. This paper examines how firms’ intern…
• Democratizing Digital Transformation: A Multisector Study of Low-Code Adoption Patterns, Limitations, and Emerging Paradigms
  2025 · 数字孪生 · Low-code development platforms (LCDPs) have emerged as transformative tools for accelerating digital transformation across industries by enabling rapid application development with minimal hand-coding. This paper synthes…
• Circular Material Flows, the Twin Transition of Manufacturing, and the Future of Labour
  2025 · 数字孪生 · In this chapter, we focus on the “twin transition” of manufacturing and the future of labour within the context of the circular economy and ocean plastics. Our point of departure is the sustainability challenges associat…
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis
  2025 · 地外科学 · The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis …
• Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review
  2025 · 合成生物与生物制造 · Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, and extending shelf life. The antimicrobial effectiveness of PPs has diffe…
• Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach
  2025 · 中医药工具 · The combination of traditional Chinese medicine (TCM) with chemotherapy has been widely applied in the treatment of gastric cancer (GC). However, previous clinical studies have been constrained by small sample sizes and …
• Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach
  2025 · 中医药工具 · The combination of traditional Chinese medicine (TCM) with chemotherapy has been widely applied in the treatment of gastric cancer (GC). However, previous clinical studies have been constrained by small sample sizes and …
• Ethnobotany, phytochemistry, pharmacology, and toxicology of the genus <i>Datura</i> (Solanaceae)
  2025 · 中医药工具 · Datura (Solanaceae), a traditional Chinese medicine, has been used to treat arthralgia, asthma, cough, gastrointestinal cramps, neuropathic migraine, and injuries from falls. More than 432 bioactive constituents were iso…
• Ethnobotany, phytochemistry, pharmacology, and toxicology of the genus <i>Datura</i> (Solanaceae)
  2025 · 中医药工具 · Datura (Solanaceae), a traditional Chinese medicine, has been used to treat arthralgia, asthma, cough, gastrointestinal cramps, neuropathic migraine, and injuries from falls. More than 432 bioactive constituents were iso…
• Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013
  2025 · 中医药工具 · Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement o…
• Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013
  2025 · 中医药工具 · Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement o…
• Chromatography-guided purification and characterization of <i>p-</i>hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo
  2025 · 中医药工具 · Melanogenesis is tightly regulated by tyrosinase, and its inhibition represents a key strategy in developing skin-whitening agents. In this study, p -hydroxyphenethyl anisate (HP) was identified as a potent melanogenesis…
• Chromatography-guided purification and characterization of <i>p-</i>hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo
  2025 · 中医药工具 · Melanogenesis is tightly regulated by tyrosinase, and its inhibition represents a key strategy in developing skin-whitening agents. In this study, p -hydroxyphenethyl anisate (HP) was identified as a potent melanogenesis…
• Computational insights into mercuric reductase from <i>Pseudomonas fluorescens</i>: a bioinformatic and molecular dynamics approach for mercury detoxification
  2024 · AI 驱动科学发现 · Mercury (Hg) pollution poses significant threats to human health and ecosystems worldwide due to its persistence, bioaccumulation, and toxic effects. This study focuses on mercuric reductase from Pseudomonas fluorescens …
• Immunoanalytical Detection of Conserved Peptides: Refining the Universe of Biomarker Targets in Planetary Exploration.
  2024 · 地外矿物 · Ancient peptides are remnants of early biochemistry that continue to play pivotal roles in current proteins. They are simple molecules yet complex enough to exhibit independent functions, being products of an evolved bio…
• A bibliometric analysis of lipid peroxidation in alcoholic liver disease from 2001 to 2024
  2024 · 脑科学 · Alcoholic liver disease (ALD) is the major liver disease burden among the world, and one of the most significant pathogenesis is lipid peroxidation (LPO), which has been shown to participate in a wide range of diseases. …

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